iiinova — where your digital self keeps evolving

tomsextonlab.bsky.social @tomsextonlab.bsky.social · 20/12/2024

The perfect addition to our Christmas tree: an ES cell and a cancer cell, knitted by the super talented @cathieerb

tomsextonlab.bsky.social @tomsextonlab.bsky.social · 16/12/2024

From 2023: out now in @plosbiology.org 👇 TLDR: Transcription CAN directly remodel TADs... in specific contexts. Big congrats to Sanjay and @yousra_zouari who spearheaded the project, and @djost_physbiol +Hossein

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tomsextonlab.bsky.social @tomsextonlab.bsky.social · 16/12/2024

We've now joined BlueSky - we'll try and catch up with all the Twitter/X expats asap

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tomsextonlab.bsky.social @tomsextonlab.bsky.social · 16/12/2024

Out now in @ScienceAdvances 👇 science.org/doi/10.1126/... A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin

science.org

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics

Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.

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