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Tin Nguyen

@tinvtnguyen.bsky.social

41 followers 109 following 0 posts

Grad Student-Waser group, EPFL.

Posts Replies Media

Reposted by Tin Nguyen

Nature Chemistry @natchem.nature.com · 25/02/2025

Take a look at the associated News & Views from Jerome Waser @lcsolab.bsky.social and Tin V. T. Nguyen @tinvtnguyen.bsky.social : www.nature.com/articles/s41... #chemsky

nature.com

Photomediated aliphatic C–H functionalization - Nature Chemistry

The C–H functionalization of inert alkanes has long been one of the most challenging reactions in organic synthesis. Now, the use of hypervalent iodine reagents has enabled the diverse functionalizati...

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Reposted by Tin Nguyen

Waser Group @lcsolab.bsky.social · 27/12/2024

Late Christmas gift from @tinvtnguyen.bsky.social and Trinh with photomediated chlorinations of C-H, C-C and C=C bond using the venerable Willgerodt reagent now as preprint on @chemrxiv.bsky.social in collaboration with Thanh at AstraZeneca chemrxiv.org/engage/chemr...

Csp3-Cl bonds are essential as diversification handles in organic synthesis and are found in many natural products and bioactive molecules. In this work, we introduce a general protocol for the selective chlorination of aryl cyclopropanes, olefins, and activated C-H bonds using the direct photoexcitation of Willgerodt-type reagents to generate chlorine radicals. Preliminary results on an iodine(I/III) catalytic process starting from abundant chloride salts are also presented. Furthermore, a one-pot protocol has been developed for the telescoped functionalization of benzylic chlorides with C, N, O, and S nucleophiles. Especially, this approach provides a platform to access 1,1-diaryl motifs, which are important building blocks for the synthesis of pharmacophores.

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