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Tim Kempchen

@tim-kempchen.bsky.social

Reposted by Tim Kempchen

jsb-lab.bsky.social @jsb-lab.bsky.social · 16/05/2025

Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint! www.biorxiv.org/content/10.1...

biorxiv.org

Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells

Transposon-Display is a highly scalable screening method that links proteins to their encoding DNA during expression in E. coli via a mutant transposase. Leveraging this system, we identified AI-desig...

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Reposted by Tim Kempchen

Gregor Hagelueken @gha14.bsky.social · 18/05/2025

Thanks to @biancabroske.bsky.social , @scbinder.bsky.social , @tim-kempchen.bsky.social and all the other authors for a fantastic collaboration. A big thank you goes to the developers of #RFdiffusion, #Chroma, #Bindcraft and others to make these amazing algorithms available.

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