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Sophie Binder

@scbinder.bsky.social

23 followers 49 following 0 posts

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Reposted by Sophie Binder

Gregor Hagelueken @gha14.bsky.social · 18/05/2025

Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...

biorxiv.org

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins

Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...

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Reposted by Sophie Binder

Sorek Lab @soreklab.bsky.social · 30/01/2025

Out today @ Science: TIR signaling activates caspase-like immunity in bacteria We report a new immune signaling molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats Francois Rousset, Ilya Osterman and coauthors! www.science.org/doi/10.1126/...

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Reposted by Sophie Binder

Gregor Hagelueken @gha14.bsky.social · 24/11/2024

Substrate binding proteins and nanobodies - that’s protein biochemistry heaven. In our new publication we characterized a nanobody that allosterically inhibits the SBP VcSiaP. Amazing job by @nschneberger.bsky.social and thanks to everyone involved! As always a great team effort! rdcu.be/d1foN

rdcu.be

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein

Communications Biology - Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.

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