Nature Protocols, Published online: 25 August 2026; doi:10.1038/s41596-026-01428-9Uniform two-dimensional platelets made from synthetic polymers can range in size from 100 nm to several micrometers and have diverse applications. This Protocol describes the synthesis and crystallization-driven self-assembly of poly(ε-caprolactone)-based polymers.

Uniform two-dimensional platelets made from synthetic polymers can range in size from 100 nm to several micrometers and have diverse applications. This Protocol describes the synthesis and crystalliza...

Control of surface patterns in assembled nanostructures is desirable, but challenging to achieve. Here, the authors report the development of a flow-based crystallisation-driven self-assembly method f...

The persistence of per- and polyfluoroalkyl substances in the environment is becoming a major health concern, yet studying their fate and behaviour in complex media is limited due to the lack of suita...

We demonstrate a triplex-based architecture for DNA-templated synthesis. This study is motivated by progress towards the development of a synthetic ribosome – autonomous, genetically programmable, molecular machinery for synthesis. Such schemes for the creation and evolution of chemically diverse DNA-tagged chemica

Achieving precise spatiotemporal modulation of immunostimulatory effects remains a fundamental barrier in tumor immunotherapy, particularly in the context of limited tumor antigen exposure and an immunosuppressive microenvironment. Herein, we present a light-responsive “dynamic nanopatch” platform that addresses these challenges through morphology-directed and interface-programmed immunoactivation. Constructed from crystalline poly(ε-caprolactone) and integrated with photothermal conversion elements, the nanopatch undergoes a near-infrared (NIR)-triggered morphology-dynamic transition from a two-dimensional planar structure to a zero-dimensional spherical counterpart. This dynamic structural transformation enables programmable interactions with the cellular membrane, establishing a versatile nanointerface capable of the in situ regulation of cancer cell membrane integrity. Upon NIR irradiation, the nanopatch stably adheres to the tumor cell surface and initiates a cascade of adhesion, deformation, and internalization events. This process promotes localized mechanical stress and membrane perturbation, enhancing the release of tumor-associated antigens and damage-associated molecular patterns, which collectively initiate potent immunogenic cell death. Subsequent activation of antigen-presenting cells leads to robust adaptive immune engagement and amplified immune cell infiltration within the tumor microenvironment. This morphodynamic nanopatch offers a highly controllable strategy for cancer immunotherapy and a new paradigm for interface-programmed functionalities with broad implications for precision medicine, immunotherapy, and biomaterial engineering.