iiinova — where your digital self keeps evolving

Reposted by Thierry Grange

Arev P. Sümer @arevsumer.bsky.social · 01/01/2026

It is a pleasure to work with Stephane! Great position in Paris 👇

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Thierry Grange @thierrygrange.bsky.social · 01/01/2026

A very promising starting lab, a friendly PI, an opportunity for a career.

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Thierry Grange @thierrygrange.bsky.social · 23/08/2025

Administrative retirement, but not yet ready to give up science. We will continue on another floor. No chance that we purify nuclei anymore, though. Enjoy it.

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Thierry Grange @thierrygrange.bsky.social · 15/12/2024

Do I understand properly that you imputed only variants that are common today, and thus none of the specific variants that are used to infer that they didn't contribute ancestry to the subsequent waves?

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Thierry Grange @thierrygrange.bsky.social · 15/12/2024

How come imputation with modern genomes can be accurate if Ranis and Zlaty Kun have not contributed ancestry to later arriving anatomically modern humans as claimed in the paper? If they don't share their specific ancestry with modern humans, imputation should not work at these specific positions.

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Reposted by Thierry Grange

Institut Jacques Monod @ijmonod.bsky.social · 09/12/2024

📣Exposition AGRIPOP 📆 Jusqu'au 16 décembre 2024 📍 Hall A des Grands Moulins / Université Paris Cité Il reste encore 1 semaine pour visiter AGRIPOP, une exposition mise en place par l'équipe "Épigénome & Paléogénome” (@thierrygrange.bsky.social) de l’@ijmonod.bsky.social ! 🔗https://urls.fr/HPX142

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Thierry Grange @thierrygrange.bsky.social · 01/12/2024

🧪 #aDNA 🧬🖥️ A very interesting paper by Gözde Atağ, Mehmet Somel and colleagues of METU showing how f-statistics results can be confounded by low-level admixture from an unaccounted source. academic.oup.com/genetics/art...

academic.oup.com

An explanation for the sister repulsion phenomenon in Patterson's f-statistics

Abstract. Patterson's f-statistics are among the most heavily utilized tools for analyzing genome-wide allele frequency data for demographic inference. Bey

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Thierry Grange @thierrygrange.bsky.social · 01/12/2024

I started a scientific discussion with another colleague who posted this paper where I argued that these creations of new paleospecies names for a subset of bones were not helping in a better understanding of human evolution, on the contrary. He preferred to block me than being contradicted. 🥲

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Thierry Grange @thierrygrange.bsky.social · 01/12/2024

If you can reformulate your question after reading them, if you still want to discuss this matter. Thanks.

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Thierry Grange @thierrygrange.bsky.social · 01/12/2024

I will answer publicly later today. Meanwhile, you can find the articles I mentioned here filesender.renater.fr?s=download&t...

filesender.renater.fr

FileSender

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

🏺🧪 #aDNA #Evolution 🧬🖥️ Reposting a scientific exchange with a colleague who proposes paleospecies and who is not willing to be challenged about what he is doing and prefers to block posts to silence the disagreements.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

Defining categories can be useful to structure our thinking, but categories can be counterproductive when they hide the relationships that exist between different parts. I am concerned that many paleospecies fall into the counterproductive category.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

They do not result from a bona fide biological selection. The risk is just very high that phenotypic diversity within a metapopulation is overinterpreted as defining features of a biological species.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

Paleospecies are resulting from a different purely random process: the chances of a favorable set of taphonomic conditions favoring preservation and the serendipitous discovery of the bones.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

Biological species result from the subsampling through time of the past biodiversity and the various bushy branches of metapopulations. This subsampling was involving both selection and chance but has been validated by time and survival.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

I agree with your point and this is exactly why I am not convinced by many paleospecies, not talking about the very concept of paleospecies.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

There were good biological reasons that Svante Paabo did not name the Denisovans as Homo denisovans. I find it useful to integrate multiple perspectives. Genomics can, and should, in my view, widen the perspective of Paleoanthropology.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

I don't see that separating Homo longi and Denisovians into different species and renaming the Denisovians Homo juliensis is lumping and is clarifying the landscape.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

I read the paper just before posting anything. I see that they are oversplitting and even adding a new species, and I think that it had more confusion than clarity.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

... you can better describe it as a bushy evolution within (a) structured metapopulation(s) showing local phenotypic variability, sometime adaptative. Putting a few rigid boxes (species) into this complex landscape based on a few bones biases our thinking process and hides the full picture.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

The problem I see with the species concept is that it was used since the 18th century to describe highly divergent lineages after all the intermediate branches were removed through random evolution and sometimes selection. When you study the evolutionary process over a short (1 My) distance...

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

Putting boxes (species names) around subparts of a bushy evolutionary tree hampers our understanding of evolution. See www.nature.com/articles/s41... for a better understanding of the complexity of human evolution integrating multiple genomes rather than relying just on isolated individual bones.

nature.com

A weakly structured stem for human origins in Africa - Nature

An analysis of models of human populations in Africa, using some newly sequenced genomes, finds that human origins in the continent can best be described by a weakly structured stem model.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

"The return of the splitters" aka "The splitters strike back"!

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Thierry Grange @thierrygrange.bsky.social · 29/11/2024

Thank you, Pedro, for your involvement in solving this issue.

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

What should I do to post this in the #aDNA list?

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

Some of the icons did not allow my post to reach the places I targeted 🏺🧪 and #aDNA

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

And explanatory videos presenting the archaeological sites and palaeogenetic analyses. 10/10

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

One drawing from Celine Piret in the exhibition 9b/10

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

There are also artistic representations of a few of the Neolithic individuals buried in the Aisne valley using inferences from their phenotypes deduced from the genetic analyses. Drawings were done by the talented Celine Piret celpiret.wixsite.com/monsite 9/10

celpiret.wixsite.com

Archéologie | Belgique | Céline Piret illustration en archéologie

Archéologue de formation et de profession, Céline Piret réalise des illustrations à vocation scientifique, didactique mais aussi de vulgarisation (notamment BD). Milieu muséal, expositions temporaires...

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

We also reconstituted the excavation of a burial from the Aisne valley. 8/10

Reconstitution of the archeological excavation of a Neolithic burial

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

... and one more from the Aisne valley, but there are several other material that I won’t show here. 7/10

Neolithic silex spear points from the Aisne valley

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

...and material from the Aisne valley. 6/10

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

In the exhibition, we present didactic material, facsimile reproductions of material from Çatal Höyük, printed and painted by the talented Laurent Aubry from Trajectoires 5/10

A mother goddess statue from Çatal Höyük

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

… and from a Northtwestern European point of migration, the Aisne Valley in the Paris basin in Northern France, studied over the years by our archaeologist collaborators of the Trajectoire laboratory trajectoires.cnrs.fr ...4/10

trajectoires.cnrs.fr

Page d'accueil - Laboratoire « Trajectoires. De la sédentarisation à l'état »

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

The Agripop exhibition deals with the beginning of the spread of farming into Europe as seen with paelogenomics. This exhibition project evolved from the Neomatrix research network @neomatrix.bsky.social 2/10

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

Dear Eryn. Please add me to the science feed. Thanks. I am heading a lab at the Institut Jacques Monod in Paris studying various aspects of human and domestic animal evolution using evolutionary genomics and paleogenomics. Lab web site: www.ijm.fr/research-top...

ijm.fr

Grange Geigl Lab

Epigenomics and Paleogenomics THIERRY GRANGE & EVA-MARIA GEIGLWe study the evolution of genomes to deepen the understanding of the relationship between genotypes and phenotypes. Recent phenotypic adap...

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

This interesting post missed the #aDNA tag to appear in the paleogenetic group.

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Thierry Grange @thierrygrange.bsky.social · 14/11/2024

Here is a list of people of aDNA people I follow that should also be listed in this starter pack bsky.app/profile/isba... bsky.app/profile/juli... bsky.app/profile/deep... bsky.app/profile/evan... bsky.app/profile/laru... bsky.app/profile/pont... bsky.app/profile/ezgi... bsky.app/profile/dile...

bsky.app

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Thierry Grange @thierrygrange.bsky.social · 24/10/2024

An interesting piece of evidence about the beginning of sheep domestication and its spread into Europe thanks to our collaboration with the Metu group, where we brought a perspective from Neolithic France. academic.oup.com/mbe/article/... 🧪 ⚒️ #Paleobio 🖥️🧬🏺

academic.oup.com

The Population History of Domestic Sheep Revealed by Paleogenomes

Abstract. Sheep was one of the first domesticated animals in Neolithic West Eurasia. The zooarchaeological record suggests that domestication first took pl

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Thierry Grange @thierrygrange.bsky.social · 09/12/2023

Oui, c'est clair que si le PR qui décide quels sont les axes de recherche à soutenir, il y a 100% de chances que tout arrive trop tard. On est en train de focaliser le pays sur le créneau de la destination touristique.

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Thierry Grange @thierrygrange.bsky.social · 13/11/2023

Nice work, I like the second benchmark

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Reposted by Thierry Grange

David Hughes @filmcritic.bsky.social · 11/11/2023

The Orange Puffer, also known as the Bottom-feeding Liar Fish. It is avoided by all marine creatures since it poisons the waters around itself.

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