iiinova — where your digital self keeps evolving

Reposted by Thierry Grange

Arev P. Sümer @arevsumer.bsky.social · 01/01/2026

It is a pleasure to work with Stephane! Great position in Paris 👇

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Thierry Grange @thierrygrange.bsky.social · 01/01/2026

A very promising starting lab, a friendly PI, an opportunity for a career.

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Thierry Grange @thierrygrange.bsky.social · 15/12/2024

Do I understand properly that you imputed only variants that are common today, and thus none of the specific variants that are used to infer that they didn't contribute ancestry to the subsequent waves?

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Thierry Grange @thierrygrange.bsky.social · 15/12/2024

How come imputation with modern genomes can be accurate if Ranis and Zlaty Kun have not contributed ancestry to later arriving anatomically modern humans as claimed in the paper? If they don't share their specific ancestry with modern humans, imputation should not work at these specific positions.

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Reposted by Thierry Grange

Institut Jacques Monod @ijmonod.bsky.social · 09/12/2024

📣Exposition AGRIPOP 📆 Jusqu'au 16 décembre 2024 📍 Hall A des Grands Moulins / Université Paris Cité Il reste encore 1 semaine pour visiter AGRIPOP, une exposition mise en place par l'équipe "Épigénome & Paléogénome” (@thierrygrange.bsky.social) de l’@ijmonod.bsky.social ! 🔗https://urls.fr/HPX142

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Thierry Grange @thierrygrange.bsky.social · 01/12/2024

🧪 #aDNA 🧬🖥️ A very interesting paper by Gözde Atağ, Mehmet Somel and colleagues of METU showing how f-statistics results can be confounded by low-level admixture from an unaccounted source. academic.oup.com/genetics/art...

academic.oup.com

An explanation for the sister repulsion phenomenon in Patterson's f-statistics

Abstract. Patterson's f-statistics are among the most heavily utilized tools for analyzing genome-wide allele frequency data for demographic inference. Bey

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

🏺🧪 #aDNA #Evolution 🧬🖥️ Reposting a scientific exchange with a colleague who proposes paleospecies and who is not willing to be challenged about what he is doing and prefers to block posts to silence the disagreements.

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Thierry Grange @thierrygrange.bsky.social · 30/11/2024

"The return of the splitters" aka "The splitters strike back"!

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

What should I do to post this in the #aDNA list?

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

Some of the icons did not allow my post to reach the places I targeted 🏺🧪 and #aDNA

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Thierry Grange @thierrygrange.bsky.social · 28/11/2024

This interesting post missed the #aDNA tag to appear in the paleogenetic group.

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Thierry Grange @thierrygrange.bsky.social · 24/10/2024

An interesting piece of evidence about the beginning of sheep domestication and its spread into Europe thanks to our collaboration with the Metu group, where we brought a perspective from Neolithic France. academic.oup.com/mbe/article/... 🧪 ⚒️ #Paleobio 🖥️🧬🏺

academic.oup.com

The Population History of Domestic Sheep Revealed by Paleogenomes

Abstract. Sheep was one of the first domesticated animals in Neolithic West Eurasia. The zooarchaeological record suggests that domestication first took pl

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Thierry Grange @thierrygrange.bsky.social · 09/12/2023

Oui, c'est clair que si le PR qui décide quels sont les axes de recherche à soutenir, il y a 100% de chances que tout arrive trop tard. On est en train de focaliser le pays sur le créneau de la destination touristique.

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Thierry Grange @thierrygrange.bsky.social · 13/11/2023

Nice work, I like the second benchmark

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Reposted by Thierry Grange

David Hughes @filmcritic.bsky.social · 11/11/2023

The Orange Puffer, also known as the Bottom-feeding Liar Fish. It is avoided by all marine creatures since it poisons the waters around itself.

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

Yes, great stuff and ideas were already formalized a while ago. We often have the technologies now to address with more precision these ideas, but the ideas were there sitting for a long time. Ideas now are often finding the way to apply the technology to tackle these old fundamental ideas.

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

Finally, for French-speaking readers, we summarized our finding in this article from @FR_Conversation . 14/14 theconversation.com/homo-sapiens...

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

None of this would have been possible without an amazing collaboration with Andy Bennett, Oguzhan Parasayan and Eva-Maria Geigl and the Ukrainian-French archeologists team. Eva-Maria has contributed a behind the story blog about it. 13/14 ecoevocommunity.nature.com/posts/crimea...

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

Finally, the Buran Kaya III individuals are more closely related to present-day individuals from Europe. 12/14

Genetic proximity of the Buran Kaya III individuals with modern Human populations as assessed with outgroup-f3-statistics. Bennett, Parasayan et al., 2023

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

The Gravettian culture has produced stunning female sculptures like the various Venuses of Vestonice and Willendorf and the head of the Dame de Brassempouy. The genetic relationships support the initial assumption of a. Yanevich that Buran Kaya III represented an early Gravettian stage. 11/14

Representation of the genetic and cultural links between the Buran Kaya III individuals and the Western Gravettian. E.M. Geigl and T. Grange

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

The Buran Kaya III individuals were most closely related to later individuals from Western Europe associated with the Gravettian culture, in particular those of the Fournol cluster. 10/14

Genetic proximity of the Buran Kaya III individuals with other Paleolithic individuals as assessed with outgroup-f3-statistics. Bennett, Parasayan et al., 2023

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

They shared also ancestry with individuals from the Caucasus suggesting that this Out of Africa wave used this route to Eurasia. 9/14

Graph of f4-statistics analyses showing the relationships with the Caucasus Hunter Gatherers of the Buran Kaya III individuals. Bennett, Parasayan et al., 2023

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

In contrast to what was previously assumed, our analyses revealed that the Homo sapiens arriving after the Campanian-Ignimbrite eruption encountered survivors of the previous migration events and admixed with individuals related to the Zlaty Kun woman. 8/14

Admixture graph of the Buran Kaya III individuals showing that they received gene flow from more ancient individuals related to the Zlaty Kun woman. Bennett, Parasayan et al., 2023

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

Even though the bones contained only traces of ancient DNA, using our improved aDNA lab procedures and thanks to the aseptic excavations, we could obtain enough genomic information to study 740 000 SNPs for comparison with previously obtained more recent and more ancient genomes. 7/14

Members of the Epigenome and Paleogenome team of the Institut Jacques Monod analyzing the Buran Kaya III samples. Photos: E.M. Geigl and T. Grange

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

We studied partial genomes of two tiny pieces of skulls that were collected aseptically in 2009 by Laurent Crépin. 6/14

Excavation team taking special precaution measures to avoid contamination of bones with DNA from excavators. Photos: S. Péan and A. Yanevich

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

Layers 6-1 and 6-2 yielded fragments of human bones dated around 37-36 000 years ago, body ornament made of mammoth ivory and various lithic artefacts that, according to Alexandr Yanevich, were reminiscent of later Gravettian assemblages. 5/14

Body ornaments made of mammoth ivory from the Buran Kaya III site. Photos: L. Crépin

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

The Buran Kaya III site was excavated by a Ukrainian-French team led by Aleksandr Yanevich and Stéphane Péan . Buran-Kaya III is a rockshelter located in Crimea (Ukraine). It provides an exceptional stratigraphic sequence extending from the Middle Paleolithic to the Neolithic. 4/14

External view of Buran Kaya III rock shelter. CC BY 4.0

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

This climatic crisis is associated with the end of the Neandertal and of the earlier Homo sapiens populations that arrived before as represented by the Zlaty Kun or Bacho Kiro genomes. 3/14

Reconstitution of the Zlaty Kun woman. Photo: Cicero Moraes

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

This period of 37-36 000 years is a key period to understand the peopling of Europe since it directly follows a major cold climatic crisis, the Heinrich 4 stadial that was accompanied by a super-volcano eruption of the Campi Flegrei near Naples, known as the Campanian-Ignimbrite eruption. 2/14

Trail of ashes of the Campanian-Ignimbrite super eruption 39 000 years ago. . CC BY 4.0

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Thierry Grange @thierrygrange.bsky.social · 23/10/2023

The paper from our team at @IJMonod on the #paleogenomic #aDNA analyses of two 37-36 000 year-old humans from the Buran Kaya III site is out today in @NatureEcoEvo. I will take you through a short summary of the main findings. 1/14 www.nature.com/articles/s41... rdcu.be/dphgx

The skull fragments of the Buran Kaya III site that were analyzed genetically. Photos: E.M. Geigl

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Thierry Grange @thierrygrange.bsky.social · 09/10/2023

So much hate in the mind of so many people. And hate fuels words and acts that fuels hate. Tragic.

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Thierry Grange @thierrygrange.bsky.social · 06/10/2023

J'ai essayé Mastodon ne trouvant plus mon bonheur sur Twitter et je ne m'y suis pas retrouvé, trop difficile de combiner centres d'intérêt et rencontres aléatoires. A peine arrivée ici, après une semaine sur bsky, je trouve que cela ressemble au vieux Twitter en mieux. 🙂

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Thierry Grange @thierrygrange.bsky.social · 04/10/2023

Yes, they played a key role in making the Kariko Weissman discoveries so important, and they hired Kariko when she was dumped from UPenn

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Reposted by Thierry Grange

Anne Carpenter @drannecarpenter.bsky.social · 02/10/2023

Nobel prize in physiology or medicine awarded to Katalin Karikó and Drew Weissman! Who Developed the Revolutionary mRNA Technology inside COVID Vaccines 🎉🎉🎉 www.nobelprize.org

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Thierry Grange @thierrygrange.bsky.social · 01/10/2023

Katalin Kariko? It would be a good symbol of the dysjunction between the importance of the contribution and the recognition by CNS papers and big grants. And a woman!

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