Reposted by Thibault G. Sana, PhDPeter Dougherty @peterdoug.bsky.social · 29/12/2025Bacteriophages are normally classified as either virulent or temperate. Reality is, of course, more complicated! Here we show many bacterial isolates contain non-temperate phages that can persist through restreaking. Thanks to all co-authors for such a great collaboration! 03113
Thibault G. Sana, PhD @thibgsana.bsky.social · 25/08/2025A plant symbiont in the phyllosphere uses two distinct T6SS-antibacterial weapons to get rid of potential competitors! 🏹🦠 Proud to have had the opportunity to take part to this exciting project, and fantastic work from the @acarlier.bsky.social lab! 120
Reposted by Thibault G. Sana, PhDPetya Krasteva @krastevalab.bsky.social · 06/06/2024The latest completed work from our ERC StG BioMatrix is now online 🤩🦠🧫🔬🧪🤓: mechanisms for c-di-GMP sensing and synthase activation by proxy, pEtN-transferase recruitment and polymer modification: www.biorxiv.org/content/10.1... 054
Thibault G. Sana, PhD @thibgsana.bsky.social · 24/01/2024We recently published a paper @CurrentBiology on a novel and conserved Proteobacterial scaffold observed by #CryoEM formed by BcsD and a Proline-rich partner, bound to cellulose synthase, and involved in biofilm structuration and strength www.cell.com/current-biol... 132
Thibault G. Sana, PhD @thibgsana.bsky.social · 08/01/2024Plant secrete cellulose in a highly orderly fashion contrarily to most bacteria which secrete amorphous cellulose. In plant, this is achieved by the "rosettes" formed of cellulose synthases attached to a cytoskeletal scaffold Figure from: www.nature.com/articles/s41... 110
Reposted by Thibault G. Sana, PhDPetya Krasteva @krastevalab.bsky.social · 22/12/2023Kicking off the winter with our latest paper on bacterial cellulose (BC) secretion 🤩🤩🤩!! Roles for BcsD/CesD beyond BC crystallinity and more dedicated intracellular BcsD-Proline rich partner scaffolds for cellulose secretion across Proteobacteria: www.cell.com/current-biol... 331
Reposted by Thibault G. Sana, PhDAsaf Levy @asaflevylab.bsky.social · 20/12/2023Interested in bacterial toxins? Check out our paper in @mbiojournal "Toxinome—the bacterial protein toxin database". An interactive database of 1.4M toxins and 491K antitoxins encoded in 59K bacterial genomes. journals.asm.org/doi/10.1128/... 072
Thibault G. Sana, PhD @thibgsana.bsky.social · 06/12/2023Ever wondered how Pseudomonas aeruginosa "choose" between planktonic and biofilm lifestyles, at the molecular level? 🦠🔬🧐 #CryoEM Fantastic team work from the @krastevalab.bsky.social (and yes, I'm biased 😊) See the paper here: www.pnas.org/doi/10.1073/... 095
Thibault G. Sana, PhD @thibgsana.bsky.social · 23/11/2023Quite an interesting work showing that a bacterial pathogen can actively stimulate itching, to induce scratching and further skin-damage 😵💫 www.cell.com/cell/fulltex... 061
Reposted by Thibault G. Sana, PhDkevin @kevinng.bsky.social · 21/11/2023Spatial host–microbiome sequencing reveals niches in the mouse gutnature.comSpatial host–microbiome sequencing reveals niches in the mouse gut - Nature BiotechnologySpatial host–microbiome sequencing simultaneously profiles microbes and host transcriptomes from mouse colons. 1137