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Debabrata Laha

@thelahalab.bsky.social
56 followers 84 following 7 posts

Assistant Professor, Department of Biochemistry, Indian Institute of Science, Bangalore. Molecular Plant Physiology, Inositol Phosphate Biology, Cell Signalling. Former @ZMBP Tuebingen, @LMCB UCL

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Reposted by Debabrata Laha
Lorraine Reese @lorraine-reese.bsky.social · 11/08/2026
If you're interested in our 'Inositol Phosphate and Pyrophosphate Signalling' meeting (abstract deadline Thursday!), you may be interested in these related articles from our journals 🧪 bit.ly/4xsXIfW
Biochemical Society Scientific Meeting on Inositol Phosphate and Pyrophosphate Signalling 2026. York, UK. 13-15 October 2026. Earlybird deadline 13 August 2026. Abstract submissions now open. Includes image of delegates in a lecture theatre asking questions and logos for the event and Biochemical SocietyRelated Content. Our Biochemical Society Journals have curated a list of relevant, related reading for Inositol Phosphate and Pyrophosphate Signalling:

- Phosphorus-specific, liquid chromatography inductively coupled plasma mass spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism
- Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease
- A minimum catalytic unit for synthesis of InsP6 and 5-PP-InsP5 in Arabidopsis
- Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-InsP7
- The ring rules the chain — inositol pyrophosphates and the regulation of inorganic polyphosphate
- Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method
- Versatile roles of inositol hexakisphosphate in the ubiquitin-proteasome system

Includes logo for Portland Press, the publishing arm of the Biochemical Society
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Reposted by Debabrata Laha
Lorraine Reese @lorraine-reese.bsky.social · 10/07/2026
Join @blindlab.bsky.social, @structplantbio.bsky.social, @thelahalab.bsky.social and many others at Inositol Phosphate and Pyrophosphate Signalling in October, in the beautiful medieval city of York 🧪 bit.ly/4p16yP3
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Reposted by Debabrata Laha
Gabriel Schaaf @gabrielschaaf.bsky.social · 23/05/2026
I am happy to share that the final version of our review on Metabolism, Perception, and Functions of Inositol (Pyro)Phosphates in Plants has been published. Many thanks to Ricardo Giehl @leibnizipk.bsky.social for this great collaboration - www.annualreviews.org/content/jour...
annualreviews.org
Metabolism, Perception, and Functions of Inositol (Pyro)Phosphates in Plants
Inositol phosphates and pyrophosphates are small, water-soluble molecules involved in a range of physiological processes across eukaryotic organisms, including plants. Over the past two decades, signi...
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Reposted by Debabrata Laha
Martina Ried-Lasi @martinaried.bsky.social · 22/05/2026
Deeply grateful to all co-authors for their contributions, especially Henning Jessen @jessenlab.bsky.social and Dorothea Fiedler for bringing their fantastic expertise to this project. Very happy to see this story published!
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Debabrata Laha @thelahalab.bsky.social · 23/05/2026
Nice piece of work. Congratulations to Gabriel, Martina and entire team!
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Reposted by Debabrata Laha
Henning Jessen @jessenlab.bsky.social · 02/03/2026
interested in inositol pyrophosphate interactors in plants? here is a complete list based on photoaffinity pulldown. congrats to Kevin and many thanks to all fantastic collaborators. advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants
Inositol pyrophosphates (PP-InsPs) are central regulators of eukaryotic signaling events. While certain PP-InsP isomers have been conclusively linked to the regulation of phosphate homeostasis throug...
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Reposted by Debabrata Laha
Henning Jessen @jessenlab.bsky.social · 28/02/2026
onlinelibrary.wiley.com/doi/10.1002/... Caged Magic Spot Nucleotides with 4 or 5 phosphates can now be delivered into living E coli cells and be released with light on demand. Congratulations to Christoph Popp for all the great work.
onlinelibrary.wiley.com
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Reposted by Debabrata Laha
Agrisera antibodies @agrisera.bsky.social · 11/12/2025
In celebration of Agrisera’s 40th anniversary, we have conducted a series of short interviews with scientists, who have supported the development of Agrisera's antibody collection. Read full interview with Assistant Prof. Debabrata Laha: www.agrisera.com/en/Agrisera-...
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Debabrata Laha @thelahalab.bsky.social · 25/11/2025
The expanding landscape of inositol phosphate signaling network in land plants - Ghosh - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
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Reposted by Debabrata Laha
Nature Chemical Biology @natchembio.nature.com · 31/10/2025
Our November issue is live! www.nature.com/nchembio/vol... The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
The cover of the December issue. The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
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Debabrata Laha @thelahalab.bsky.social · 31/10/2025
Really delighted and humbled to see that we made it into cover! This is first time for us. Please see more details about work in PMID: 40745478.
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Debabrata Laha @thelahalab.bsky.social · 11/09/2025
Happy to share our work on identification of non-archetypal activity of IPK2 in producing inositol pyrophosphate 4/6-IP7 and regulating heat stress acclimation-conserved in studied land plants. Grateful to @jessenlab.bsky.social for wonderful collaborative efforts! journals.plos.org/plosgenetics...
journals.plos.org
Conservation of heat stress acclimation by the IPK2-type kinases that control the synthesis of the inositol pyrophosphate 4/6-InsP7 in land plants
Author summary Inositol pyrophosphates (PP-InsPs) are eukaryote-specific cellular messengers that control a plethora of critical physiological processes, ranging from cellular metabolism to cellular e...
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Debabrata Laha @thelahalab.bsky.social · 31/07/2025
Delighted to share our work "GA-independent DELLA regulation by pyrophosphate in a nonvascular land plant" published now in Nature Chemical Biology! @natchembio.nature.com www.nature.com/articles/s41...
nature.com
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant - Nature Chemical Biology
A noncanonical pathway of DELLA regulation by a conserved inositol pyrophosphate synthase was identified in the liverwort, Marchantia polymorpha, that lacks the canonical gibberellin-induced DELLA deg...
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Reposted by Debabrata Laha
Henning Jessen @jessenlab.bsky.social · 01/07/2025
congrats to Kevin! His paper on new inositol pyrophosphates is out in @angewandtechemie.bsky.social doi.org/10.1002/anie...
doi.org
Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP‐InsP4 Isomers in Plant Signaling
Inositol pyrophosphates (PP-InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostasis and energy metabolism across species. Despit...
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Henning Jessen @jessenlab.bsky.social · 18/04/2025
An alternative strategy to access inositol derivatives by stereoselective dephosphorylation. Happy to share the work by Markus Haener together with @gabrielschaaf.bsky.social and many others. chemrxiv.org/engage/chemr...
chemrxiv.org
Stereoselective chemoenzymatic phytate transformations provide access to diverse inositol phosphate derivatives
Phosphorylated myo-inositols (InsPs) are essential cytoplasmic signaling molecules, while their lipidated analogs (PtdInsPs) play a crucial role in membrane signaling. Stereoselective synthesis of the...
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Reposted by Debabrata Laha
Hiro Nakagami @grandpahiro.bsky.social · 17/04/2025
The final version of our study on SERK-BIR module in Marchantia is out. Congratulations Cate and many thanks to collaborators! www.sciencedirect.com/science/arti...
sciencedirect.com
Conserved role of the SERK-BIR module in development and immunity across land plants
SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASES (SERKs), which are subfamily II of leucine-rich repeat receptor-like kinases (LRR-RLKs), play diverse role…
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Reposted by Debabrata Laha
Henning Jessen @jessenlab.bsky.social · 28/03/2025
Happy to share Kevin´s great work on PP-InsP4 synthesis and analysis now available on Chemrxiv! chemrxiv.org/engage/chemr...
chemrxiv.org
Expanding the PP-INSP₄ Toolbox: Synthesis, Stereochemical Assignment, and Application in Plant Phosphate Signaling
Inositol pyrophosphates (PP-InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostasis and energy metabolism across species. Despite...
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