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the Hoffman Lab

@thehoffmanlab.bsky.social
105 followers 47 following 54 posts

We are The Hoffman Lab based at Bielefeld University, Germany! Our group aims to understand the genetic basis of fitness variation in and among natural populations. We work on pinnipeds 🦭, fungi 🍄 and birds 🐥. thehoffmanlab.com

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the Hoffman Lab @thehoffmanlab.bsky.social · 10/08/2026
Both genetic variation and epigenetics can affect fitness, but how are the two expected to interplay? Can epigenetics buffer against the effects of deleterious mutations, or do they make their effects worse? Our latest Opinion Piece on this topic is now published! doi.org/10.1098/rstb...
doi.org
The interplay between epigenetic mechanisms and deleterious mutations: implications for fitness, evolution and conservation
Abstract. Understanding the causal effects of genetic mutations is essential for explaining fitness variation, forecasting evolutionary trajectories and as
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the Hoffman Lab @thehoffmanlab.bsky.social · 16/07/2026
New paper: Antarctic fur seals are Least Concern on the IUCN Red List, but 47 yrs of data show South Georgia's population (96% of global total) has declined ~1.5M since 2007. Time for a global status reassessment! 🦭📉🧪 🔗https://authors.elsevier.com/sd/article/S0006-3207(26)00317-4 📷: Oliver Krüger
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the Hoffman Lab @thehoffmanlab.bsky.social · 07/07/2026
A decade of dedication deserves a sweet celebration! 🍫👕 We recently surprised @annekep.bsky.social to celebrate her incredible 10-year anniversary with our research group. Thank you for your hard work and being an amazing colleague, Anneke! #Milestone #ResearchTeam #EmployeeAppreciation #10Years
Anneke smiling brightly wearing a blue tshirt with the lab logo in the top left corner that says "10 years evolutionary population genetics"Anneke showing the back of the tshirt that reads "10 years" and then lists current and former lab members
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the Hoffman Lab @thehoffmanlab.bsky.social · 30/06/2026
Our Special Issue co-edited by @rebeccachen.bsky.social and Bernice is out now in JAB! Seven papers about a variety of topics, all addressing several knowledge gaps in avian epigenetics. Read the editorial here! nsojournals.onlinelibrary.wiley.com/doi/10.1002/...
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the Hoffman Lab @thehoffmanlab.bsky.social · 26/06/2026
We conquered the heat at our lab retreat yesterday! 😎 Talked feedback, funding for PhDs/postdocs, growing the group, and plans for pursuing #MyGreenLab certification 🌱 Great energy all around! 🧪 #LabLife
Group picture of the lab members present at the retreat, everyone has their hands up and is smiling or making funny facesGroup picture of lab members having dinner outside
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the Hoffman Lab @thehoffmanlab.bsky.social · 15/06/2026
A massive congratulations to @anelivb.bsky.social who successfully defended her PhD thesis titled “Effects of density on Antarctic fur seals“! 🥳🎓🦭🧪
Freshly appointed dr Ane Liv Berthelsen, wearing a black graduation cap decorated with pictures and a bouldering figurine made of clayGroup picture of the Hoffman lab after Ane Liv's defence
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Ane Liv @anelivb.bsky.social · 23/04/2026
Have you considered the role of epigenetic variation in niche individualization? We explored the interplay between interindividual phenotypic variation and epigenetic processes in a paper recently published in Trends of Ecology and Evolution 🧪 Read more here: www.cell.com/trends/ecolo...
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Ane Liv @anelivb.bsky.social · 09/06/2026
Have you ever wondered about fine-scale predator-prey dynamics? 🧪 I used image data and a neural network to investigate this in Antarctic fur seals. Read more: royalsocietypublishing.org/rsos/article... #Ecology #AntarcticResearch Giant petrel stalking Antarctic fur seal pup, watercolour, ALB.
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the Hoffman Lab @thehoffmanlab.bsky.social · 09/06/2026
Our PhD candidate @anelivb.bsky.social just published new research on Antarctic fur seal predator–prey dynamics using image data and a YOLO neural network to generate automatic detections. 🧪 Read more: royalsocietypublishing.org/rsos/article... #Ecology #AntarcticResearch
royalsocietypublishing.org
Fine-scale spatiotemporal predator–prey interactions in an Antarctic fur seal colony
Abstract. Density is a major determinant of population dynamics, with high densities exacerbating intraspecific competition and disease transmission while
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Ane Liv @anelivb.bsky.social · 08/03/2026
Have you considered whether animals differ in their perception of density? We explored how differences in our senses, interpretation and past experiences shapes density perception, causing behavioral differences and affecting fitness outcomes. 🧪 nsojournals.onlinelibrary.wiley.com/doi/10.1002/...
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the Hoffman Lab @thehoffmanlab.bsky.social · 18/05/2026
A massive milestone deserves a massive shoutout! 🎓 @rebeccachen.bsky.social has successfully defended her PhD with a Summa cum laude! 🎉 We're thrilled to congratulate her and even more thrilled that she'll be staying with the group a little longer!🙏 #PhD #Congratulations #Academia
Rebecca smiling broadly after her PhD defence. She is wearing her decorated graduation cap after her PhD defence. The cap is decorated with a black grouse head made of paper mache and a big lyre made from feathers, a 3D printed DNA strand and many pictures. She is wearing a black graduation gown.A group picture of the Evolutionary Population Genetics group in front of the Verhaltensforschung building at the Bielefeld University. In the picture are: Joe, Marcos, Ira, Anneke, Jutta, David, Noemi, Beril, Rebecca, Ane Liv and Etienne
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the Hoffman Lab @thehoffmanlab.bsky.social · 05/03/2026
What is responsible and rigorous science? @anelivb.bsky.social and @rebeccachen.bsky.social spent the last two days discussing this question at the #iScienceTBD workshop at @idiv-research.bsky.social. From EDI and science communication to HARKing, p-hacking, DAGs – lots of food for thought! 🌱🧠
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the Hoffman Lab @thehoffmanlab.bsky.social · 20/02/2026
Looking for a MSc thesis or a recent graduate project? The Hoffman Lab is looking for a motivated student to work on mutation load dynamics and inbreeding depression in female black grouse! We'll investigate how deleterious mutations affect key fitness traits. Check out our website for more info! 🧬
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the Hoffman Lab @thehoffmanlab.bsky.social · 08/01/2026
Looking for a PhD opportunity in molecular ecology or know of someone? We are hiring a new PhD candidate who will be working on mutation load dynamics in banded mongoose! 🧬Read more here: thehoffmanlab.com/opportunities/. Deadline for applications is January 30th! #phd #jobs #genetics #mutationload
thehoffmanlab.com
Join The Lab!
We warmly welcome applications from students or postdocs who would like to work in our group. If you are interested in any of the research topics described on our website or have your own ideas for…
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the Hoffman Lab @thehoffmanlab.bsky.social · 07/01/2026
Massive congratulations to @ramonammm.bsky.social for successfully defending her PhD thesis last December! 🎓🥳 We wish you all the best in your new job and adventures Down Under! 🦘 🐨 🐋
Ramona broadly smiling and holding her decorated graduation cap with both hands after her PhD defence. The cap is decorated with Christmas lights, pictures and whale figurines. She is wearing a black graduation gown.
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the Hoffman Lab @thehoffmanlab.bsky.social · 19/12/2025
Merry Christmas and Happy Holidays from the Hoffman lab! 🎄 May 2026 be a great year for science ✨ Illustrations made by Ane Liv Berthelsen
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the Hoffman Lab @thehoffmanlab.bsky.social · 08/12/2025
Publication alert! ❗ Do predicted deleterious mutations reduce survival? In our latest paper lead by @rebeccachen.bsky.social published in @currentbiology.bsky.social, we compared mutation load across different age classes in black grouse.
Cover of Current Biology Vol 35, number 23, Dec 2025. It shows a picture of a black grouse, its image mirrored in a pond it is standing next to.
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the Hoffman Lab @thehoffmanlab.bsky.social · 10/10/2025
How can we make scientific events such as #conferences more #inclusive? Read about the study we conducted during #Behaviour2023 as a nice and concise summary in the press-release here 👉 aktuell.uni-bielefeld.de/2025/10/06/r...
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the Hoffman Lab @thehoffmanlab.bsky.social · 08/10/2025
Last week a very happy (and presumably very tired 😁) @ramonammm.bsky.social handed in her PhD thesis titled "Comparing Polar Ocean Soundscapes" 🥳🥳 🥳 Congratulations with this huge milestone! Looking forward to the defence and of course the celebrations afterwards!
Ramona smiling broadly and holding her thesis in front of herA picture of the front of Ramona Mattmueller's thesis titled "Comparing Polar Ocean Soundscapes"
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the Hoffman Lab @thehoffmanlab.bsky.social · 22/09/2025
Do predicted deleterious mutations explain fitness variation in wild populations? Our recent publication addresses exactly this question in black grouse, a lekking Galliform. 1/6
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the Hoffman Lab @thehoffmanlab.bsky.social · 15/09/2025
We have a brand new genome for porcini mushroom! First chromosome-scale, haplotype-resolved reference genome for Boletus edulis. A great resource for fungal genetics, and the rest of Etienne's PhD!
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the Hoffman Lab @thehoffmanlab.bsky.social · 05/09/2025
DNA as street decoration? Of course! Our very own @k-hench.bsky.social made some beautiful pictures of the @eseb2025.bsky.social street decorations at the “Festes de Gràcia”. Check out some of his pictures and read more about why we were there: thehoffmanlab.com/2025/09/05/e...
thehoffmanlab.com
ESEB 2025
Four of our lab members presented their work at the Congress of the European Society for Evolutionary Biology (ESEB 2025) in Barcelona in August. Beril presented a pilot study linked to her multi-p…
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the Hoffman Lab @thehoffmanlab.bsky.social · 21/08/2025
The genome and epigenome are not independent, so why analyse them separately? 🤔 Come and discuss our hypotheses on the interplay between deleterious mutations and epigenetic mechanisms today with @rebeccachen.bsky.social at #ESEB2025 poster number 85! 🧪🧬
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Amanda Bretman @amandabretman.bsky.social · 20/08/2025
@annekep.bsky.social shows us a super impressive long term study in Antarctica fur seals to explore interactions between inbreeding and climate change 🦭
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the Hoffman Lab @thehoffmanlab.bsky.social · 20/08/2025
Do inbred females suffer disproportionately from climate change induced changes in selection pressure? Come and find out in @annekep.bsky.social's talk today at the @eseb2025.bsky.social conference 12:00 PM - 12:15 PM in meeting room 115 #ESEB2025
Title slide of the presentation. The left side has a blue background with in white the title: "Inbreeding-mediated individual responses to climate change in Antarctic fur seals" by David Vendrami, Anneke Paijmans, Emily Humble, Ane Liv Berthelsen, Jaume Forcada and Joe Hoffman. On the right side there is a picture of a Antarctic fur seal female with light grey/brown fur coloration and a darker colored pup on her right side
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the Hoffman Lab @thehoffmanlab.bsky.social · 19/08/2025
Interested in the temporal and spatial dynamics of mutation load? Come find @k-hench.bsky.social who is investigating this in Antarctic fur seals! Poster session 2, S44 355 5-7PM tonight @eseb2025.bsky.social #eseb2025
Kosmas pointing to his scientific poster titled "dynamics of mutation load in the Antarctic fur seal" at the ESEB2025 conference
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the Hoffman Lab @thehoffmanlab.bsky.social · 19/08/2025
How do deleterious mutations affect male black grouse fitness? Find out at @rebeccachen.bsky.social's presentation today at @eseb2025.bsky.social 2:00 PM-2:15 PM, meeting room 131 🧬
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the Hoffman Lab @thehoffmanlab.bsky.social · 18/08/2025
Interested in the genomic consequences of commercial sealing? Check out Beril's poster (number 266) tonight at #ESEB2025 where she presents her study on differences in genomic inbreeding levels, bottleneck strength, and genetic load in two populations of South American fur seals 🦭🧬🧪
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the Hoffman Lab @thehoffmanlab.bsky.social · 14/08/2025
Working on mutation load, inbreeding or bottlenecks and attending ESEB2025 Congress of the European Society for Evolutionary Biology next week? Check out our lab's talks and posters 😁 Looking forward to chat with you!
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the Hoffman Lab @thehoffmanlab.bsky.social · 13/08/2025
Our very own Ramona Mattmueller @ramonammm.bsky.social and her colleague Karolin Thomisch from AWI wrote an article for the Circle Stories of the WWF Global Arctic Program.
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the Hoffman Lab @thehoffmanlab.bsky.social · 11/08/2025
Check out our new publication on mutation load dynamics in black grouse! Published today in Nature E&E 👇
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the Hoffman Lab @thehoffmanlab.bsky.social · 07/08/2025
We are now also on LinkedIN! 👉 www.linkedin.com/showcase/evo...
linkedin.com
Evolutionary Population Genetics | LinkedIn
Evolutionary Population Genetics | 10 followers on LinkedIn. One of the most fundamental goals of evolutionary and conservation biology is to elucidate the mechanisms linking genotype to fitness. To s...
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Rebecca Chen @rebeccachen.bsky.social · 31/07/2025
Do you work on mutation load? 🔬🧬 Check out our new manuscript where we show that early-life viability selection primarily targets exonic mutations, in contrast to sexual selection which acts on mutations in promoters! 🧑‍🔬 Pre-print is available now: dx.doi.org/10.2139/ssrn... 🧪 #evolution #popgen
dx.doi.org
Early-Life Viability Selection Targets Deleterious Mutations in Exons
Understanding how deleterious mutations affect fitness is fundamental to both evolutionary and conservation biology. However, most empirical studies rely on inb
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the Hoffman Lab @thehoffmanlab.bsky.social · 28/07/2025
A massive congratulations to dr Jonas Tebbe, for successfully defending his PhD on chemical phenotypes in the Antarctic fur seal!! 🥳🎓🦭 We wish all the very best to Jonas!
Jonas wearing a black gown and his graduation cap which is decorated with pictures and has a lab tube for a tassel. He is standing inside Bielefeld University in front of the room where he defended his PhD thesisJonas Tebbe sitting in a small cart decorated with balloons and a sign that says "Dr Jonas". Jonas is wearing his graduation cap and a black gown. The cart is being pulled by his former supervisor Joe Hoffman. They are outside, some parts of Bielefeld University can be seen in the background
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EvoBio Crash Course @evobiocc.bsky.social · 15/06/2025
There is still lots of time to sign up for our 2025 edition of the #EvoBioCC 🥳💚✨ It is a FREE, online course in Evolutionary Biology, made by students and for students! Please share widely and don't forget to register! 💚💚💚 docs.google.com/forms/d/e/1F...
docs.google.com
EvoBio Crash Course 2025 | Registration Form
The fourth edition of the EvoBio Crash Course has opened registration and we are very happy to have you! We are focusing on delivering a rich course on the basics of evolutionary biology so that stude...
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the Hoffman Lab @thehoffmanlab.bsky.social · 14/07/2025
🧪 Lab plastic waste is a huge problem - but what can we do about it? 🥼 In our lab, we tested whether reusing and washing microtitre plates could help reduce waste. In some cases, it works! ♻️ 🌍 Read more here: buff.ly/XOGSX0q #greenlab #sustainability #openscience
Cartoon of a female scientist wearing a lab coat and safety goggles. She is holding a PCR plate and stands in front of a bin filled with more plastic waste. The bin has a recycling logo in it. Behind the woman is written "Can we reuse laboratory items to reduce plastic waste?"
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Rebecca Chen @rebeccachen.bsky.social · 14/07/2025
Publication alert! ✨ Our recent paper in Ecology & Evolution addresses how to make conferences more inclusive. We collected observational and experimental data during Q&A sessions at the Behaviour 2023 congress hosted by Bielefeld University, and circulated a survey among conference attendees [1/4]
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the Hoffman Lab @thehoffmanlab.bsky.social · 11/07/2025
Fresh publication alert 📃! Our paper about skin and gut microbial communities in Antarctic fur seals is now available in Frontiers in Microbiology. In this study, @ecopetridish.bsky.social and colleagues found that skin microbial communities were strongly influenced by the colony membership. 1/3
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the Hoffman Lab @thehoffmanlab.bsky.social · 07/07/2025
Last week our lab member @annekep.bsky.social successfully defended her PhD and was rewarded a magna cum laude for her work! Congratulations dr. Anneke! 🥳🎓 Luckily we don't have to say our farewells yet, as Anneke will continue working on her Antarctic fur seal project as a postdoc in the group 🦭
Woman with red hair and a black cape holding a graduation capWoman with graduation cap and gown sitting in a small cart being pulled by a man
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the Hoffman Lab @thehoffmanlab.bsky.social · 23/06/2025
Last week, the Hoffman Lab had its second lab retreat! Two full days of science, inspiring stories about field work, discussions about EDI in the lab and science communication, and a lot of team-bonding while enjoying the peace of the Teutoburg forest🍃
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Rebecca Chen @rebeccachen.bsky.social · 11/12/2024
Our preprint is out! We predicted deleterious mutations and reveal the genomic mechanisms underlying fitness variation in black grouse, a classic lekking bird. Check it out doi.org/10.21203/rs.... #genomics #popgen #genetics
doi.org
Predicted deleterious mutations reveal the genomic mechanisms underlying fitness variation in a lekking bird
Deleterious mutations are ubiquitous in natural populations and, when expressed, reduce fitness. However, the specific nature of these mutations and the mechanisms through which they impact fitness r...
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