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thedoctorisvin.bsky.social @thedoctorisvin.bsky.social · 19/05/2026

Great write-up from @columbiacancer.bsky.social "A cellular wrong turn in blood cancer” on our paper from @cohesinlab.bsky.social published in @bloodjournal.bsky.social . 🔑Key point: STAG2 doesn’t change how much GATA1 there is—it changes where it can act. www.cancer.columbia.edu/news/cellula...

cancer.columbia.edu

A cellular wrong turn in blood cancer

A new study reveals how disrupted DNA navigation leads to impaired red blood cell development in myelodysplastic syndrome

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thedoctorisvin.bsky.social @thedoctorisvin.bsky.social · 18/05/2026

🚨 Paper Alert! 🚨 @bloodjournals.hematology.org Hot off the press and presented this morning at #Myeloid2026 @columbiacancer.bsky.social @columbiamed.bsky.social Congratulations to Varun and the @cohesinlab.bsky.social team! 🎉

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thedoctorisvin.bsky.social @thedoctorisvin.bsky.social · 01/10/2025

Thanks @cancerdynamics.bsky.social for highlighting this interview with @columbiacancer.bsky.social for Blood Cancer Awareness Month and our work in @cohesinlab

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Reposted by @thedoctorisvin.bsky.social

Viny Lab @cohesinlab.bsky.social · 22/09/2025

🚨 Excited to share our new preprint: Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome. This work was led by Columbia VP&S MD student Varun Sudunagunta (‼️ Program Directors: Varun is applying to IM residencies this year!) www.biorxiv.org/content/10.1...

biorxiv.org

Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

The transcription factor GATA1 has pleiotropic hematopoietic functions, particularly in erythroid and megakaryocytic ontogeny. While mechanistic investigations have uncovered many facets of GATA1 biol...

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Reposted by @thedoctorisvin.bsky.social

Herbert Irving Comprehensive Cancer Center @columbiacancer.bsky.social · 25/04/2025

Educational Session: “Dysregulation of nuclear topology in cancer: Clinical implications and emerging mechanisms” Presenter: @thedoctorisvin.bsky.social April 25, 2025, 3:30 PM - 3:50 PM CST/ 4:30 PM - 4:50 PM EST

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thedoctorisvin.bsky.social @thedoctorisvin.bsky.social · 25/04/2025

If you’re at @theaacr.bsky.social don’t miss today’s session on 3D Topology & Cancer featuring giants of the field: Jane Skok @nyulangone.bsky.social & Brad Cairns @utah.edu Imposter syndrome at an all time high! 😬 Proud to represent @cohesinlab.bsky.social @columbiacancer.bsky.social #AACR25

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thedoctorisvin.bsky.social @thedoctorisvin.bsky.social · 18/04/2025

And is it just FLI1? We don’t think so! Actually a HUGE part of this mechanism coming into focus was it helps us unify our prior PU.1 finding and may explain your zebrafish runx1 data that has been the inspiration for so much of our work! journals.biologists.com/dev/article/...

journals.biologists.com

Cohesin-dependent regulation of Runx genes

Runx transcription factors determine cell fate in many lineages. Maintaining balanced levels of Runx proteins is crucial, as deregulated expression leads to cancers and developmental disorders. We con...

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thedoctorisvin.bsky.social @thedoctorisvin.bsky.social · 18/04/2025

Nope! No change in my overall expression by RNA or protein—but a redistribution of the protein towards a much higher chromatin-bound fraction. And we think this disordering of the FLI1 cistrome is a big part of the mechanism!

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