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Reposted by Viny Lab

thedoctorisvin.bsky.social @thedoctorisvin.bsky.social · 19/05/2026

Great write-up from @columbiacancer.bsky.social "A cellular wrong turn in blood cancer” on our paper from @cohesinlab.bsky.social published in @bloodjournal.bsky.social . 🔑Key point: STAG2 doesn’t change how much GATA1 there is—it changes where it can act. www.cancer.columbia.edu/news/cellula...

cancer.columbia.edu

A cellular wrong turn in blood cancer

A new study reveals how disrupted DNA navigation leads to impaired red blood cell development in myelodysplastic syndrome

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Viny Lab @cohesinlab.bsky.social · 18/05/2026

Transcription factors don’t fail in MDS—they’re misdirected. Today in Blood, we show how loss of STAG2 rewires chromatin accessibility to redirect GATA1 and alter blood cell fate. ashpublications.org/blood/articl...

ashpublications.org

Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

Key Points. Stag2 reprograms Gata1 cistrome specificity via chromatin accessibility, a key determinant of transcription factor lineage discrimination.Loss

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Viny Lab @cohesinlab.bsky.social · 22/09/2025

🚨 Excited to share our new preprint: Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome. This work was led by Columbia VP&S MD student Varun Sudunagunta (‼️ Program Directors: Varun is applying to IM residencies this year!) www.biorxiv.org/content/10.1...

biorxiv.org

Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

The transcription factor GATA1 has pleiotropic hematopoietic functions, particularly in erythroid and megakaryocytic ontogeny. While mechanistic investigations have uncovered many facets of GATA1 biol...

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Reposted by Viny Lab

Herbert Irving Comprehensive Cancer Center @columbiacancer.bsky.social · 25/04/2025

Educational Session: “Dysregulation of nuclear topology in cancer: Clinical implications and emerging mechanisms” Presenter: @thedoctorisvin.bsky.social April 25, 2025, 3:30 PM - 3:50 PM CST/ 4:30 PM - 4:50 PM EST

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Reposted by Viny Lab

thedoctorisvin.bsky.social @thedoctorisvin.bsky.social · 25/04/2025

If you’re at @theaacr.bsky.social don’t miss today’s session on 3D Topology & Cancer featuring giants of the field: Jane Skok @nyulangone.bsky.social & Brad Cairns @utah.edu Imposter syndrome at an all time high! 😬 Proud to represent @cohesinlab.bsky.social @columbiacancer.bsky.social #AACR25

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