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Tetsuhisa Otani

@tetsuotani.bsky.social

424 followers 1.1K following 17 posts

Cell biologist interested in cell-cell junctions and epithelial biology. Associate professor at Tokyo Metropolitan University.

Posts Replies Media

Tetsuhisa Otani @tetsuotani.bsky.social · 13/03/2026

Our new review on epithelial barrier homeostasis has been published in Trends in Cell Biology(www.cell.com/trends/cell-...)! Please use the following link for free access until May 1: authors.elsevier.com/a/1mlnq3QxxT...

cell.com

Epithelial barrier homeostasis

Epithelia cover the body’s surface to form a barrier that segregates the internal body from the external environment. Tight junctions (TJs) seal the paracellular space and are crucial for the formatio...

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Reposted by Tetsuhisa Otani

Crystal Rogers, PhD @rogerslabucd.bsky.social · 10/07/2025

Please comment on this! The complexity of living systems cannot be fully recapitulated by in vitro or computational approaches alone. While advances in non-animal model technologies offer complementary tools, they lack the full physiological and developmental context of a living organism.

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Tetsuhisa Otani @tetsuotani.bsky.social · 14/01/2025

New preprint from the lab! We show that epithelial cells lacking ZO-1/ZO-2, the key scaffolding proteins of tight junctions, are eliminated when surrounded by normal cells. (1/n) www.biorxiv.org/content/10.1...

biorxiv.org

Competitive elimination of ZO-1/ZO-2-deficient cells regulates epithelial barrier homeostasis

Epithelia cover the body and form a barrier to segregate the internal body from the external environment. Epithelial tissues contact the external environment and are exposed to various stresses that a...

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