Nature Reviews Chemistry, Published online: 15 December 2025; doi:10.1038/s41570-025-00779-3This Review explores how ionizing radiation triggers drug release via water radiolysis, detailing reactive species, drug activation mechanisms and strategies for designing radiation-sensitive prodrugs and nanocarriers to enhance chemoradiation therapy with reduced systemic toxicity.

Nature Reviews Chemistry, Published online: 15 December 2025; doi:10.1038/s41570-025-00779-3This Review explores how ionizing radiation triggers drug release via water radiolysis, detailing reactive species, drug activation mechanisms and strategies for designing radiation-sensitive prodrugs and nanocarriers to enhance chemoradiation therapy with reduced systemic toxicity.

Non-covalent and covalent chemistry can be controlled by using synthetic tools, such as templates. However, selective multicomponent self-assembly remains challenging because of the many kinetic inter...

Photoelectrochemical (PEC) cells are under intensive development for the synthesis of solar fuels, but CO2 reduction typically only results in simple building blocks such as HCOO–. Here, we demonstrat...

Photoelectrochemical (PEC) cells are under intensive development for the synthesis of solar fuels, but CO2 reduction typically only results in simple building blocks such as HCOO–. Here, we demonstrat...

An early love of construction toys led the Scottish chemist to thread molecules together, opening up a new field of chemistry.