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Takuya Azami

@tazami.bsky.social

80 followers 128 following 6 posts

Developmental biologist at MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh.

Posts Replies Media

Reposted by Takuya Azami

Development @dev-journal.bsky.social · 25/08/2026

Harnessing the murine inner cell mass mechanical environment enhances derivation of in vitro nascent primitive endoderm precursor cells Read this Article from our special issue #DevSIextracellular by Elena Corujo-Simon, Jennifer Nichols, @kevinchalut.bsky.social & co. doi.org/10.1242/dev....

Figure from Elena Corujo-Simon et al.

NPRE FGF+ cells aggregate with mESCs and contribute to host PRE in mouse blastocysts. (A) Representative confocal images of ICM aggregates made of 30 NPRE cells and 20 mESCs 8, 24 and 48 h after initial seeding. Pdgfrα H2B-GFP/+ FGF+ NPRE cells (green) and mESCs immunostained for OCT4 (magenta) are shown with nuclei stained with Hoechst. (B) Chimera injection diagram. Five NPRE cells were injected into host blastocysts at E3.5. Embryos were allowed to develop until E4.5 prior to fixation and immunostaining. (C) Representative confocal images of injected NPRE cells contributing to the host PRE in the mouse blastocyst (top) or attaching and contributing to the TE (bottom).

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Reposted by Takuya Azami

British Society for Developmental Biology @bsdb.bsky.social · 06/05/2026

Save the date! The 2027 BSDB Spring Meeting will take place on 19 - 22 April in Edinburgh. An exciting programme with a fantastic lineup of speakers showcasing developmental biology across scales! More details soon!

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Takuya Azami @tazami.bsky.social · 28/03/2026

Japan! 🇯🇵

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Takuya Azami @tazami.bsky.social · 19/12/2025

Another nice visit to Tokyo and a great catch-up with a colleague.

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Takuya Azami @tazami.bsky.social · 17/12/2025

It was a very nice visit to Tsukuba again.

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Takuya Azami @tazami.bsky.social · 27/11/2025

Thank you so much for hosting me! It was a very nice visit!

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Takuya Azami @tazami.bsky.social · 16/10/2025

Happy to share our new preprint!

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Reposted by Takuya Azami

Stanley E. Strawbridge @stanleystrawbridge.bsky.social · 04/06/2025

1/10🧵 New preprint! 🚀 We built a resource of 20 clonal human naïve pluripotent stem cell lines from 10 blastocysts. Explore embryo-to-embryo and clone-to-clone variation in one place. 👉doi.org/10.1101/2025.06.02.657331

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Reposted by Takuya Azami

Cell Reports @cp-cellreports.bsky.social · 08/04/2025

STAT3 signaling enhances tissue expansion during postimplantation mouse development

dlvr.it

STAT3 signaling enhances tissue expansion during postimplantation mouse development

Azami et al. reveal that STAT3 deletion depletes epiblast cells at implantation, causing a persistent developmental delay of around a day. STAT3 null embryonic stem cells contribute to all embryonic tissues in chimeras except blood. Mixing with wild-type cells for in vitro erythroid differentiation causes the outcompetition of STAT3 null cells.

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Takuya Azami @tazami.bsky.social · 07/04/2025

Happy to share our study on Stat3, now published in Cell Reports! Huge thanks to all collaborators! www.cell.com/cell-reports...

cell.com

STAT3 signaling enhances tissue expansion during postimplantation mouse development

Azami et al. reveal that STAT3 deletion depletes epiblast cells at implantation, causing a persistent developmental delay of around a day. STAT3 null embryonic stem cells contribute to all embryonic t...

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