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Alex Taylor @taylorlab.bsky.social · 21/09/2026

Perspective mini-review out, looking at XNA applications in the designed nucleic acid structure space with Hanyan Yu’s lab. link.springer.com/article/10.1...

link.springer.com

Empowering DNA nanotechnology with xeno-nucleic acids - Science China Chemistry

Science China Chemistry -

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Reposted by Alex Taylor

Edoardo Gianni @edogia.bsky.social · 13/02/2026

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

science.org

A small polymerase ribozyme that can synthesize itself and its complementary strand

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

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Reposted by Alex Taylor

Phil Holliger @philholliger.bsky.social · 13/02/2026

New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/... Outstanding work by @edogia.bsky.social

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Reposted by Alex Taylor

RSC Chemical Biology @rscchembio.rsc.org · 17/12/2025

📢2025 RSC Chemical Biology Emerging Investigators collection is now published online. This collection features invited contributions from early career researchers who are making significant contributions to the field of chemical biology. ➡️Read the full collection here: rsc.li/cbemi25

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Alex Taylor @taylorlab.bsky.social · 08/09/2025

New paper online! In a distillation of years of painful lessons we've learnt exploring applications of RNA-cleaving DNAzymes as agents for knockdown in cells, we showcase the troubling variety of ways that false positives & negatives can creep in - and how to avoid them. pubs.rsc.org/en/Content/A...

pubs.rsc.org

Sources of mismeasurement of RNA knockdown by DNAzymes and XNAzymes

RNA-cleaving olignucleotide catalysts composed of DNA and/or nucleic acid analogues (DNAzymes, modified DNAzymes and XNAzymes) are promising agents for specific knockdown of disease-associated RNAs. H...

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