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TaylorLab-Chembio

@taylorlab-chembio.bsky.social
480 followers 405 following 12 posts

Chemical Biology research group at the University of Arizona. New chemical reactivity for revealing new biology and therapeutic approaches. Check us out at: taylorresearchgroup.org

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TaylorLab-Chembio @taylorlab-chembio.bsky.social · 22/09/2026
Happy to share the final version of our alpha-hydroxy glycine synthesis/functionalization work, which is now out in @rsc.org journal Org. Biomol. Chem. Great work by coauthors Pooja, Debolina, and Pranab! pubs.rsc.org/ob/article/d...
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TaylorLab-Chembio @taylorlab-chembio.bsky.social · 03/06/2026
A simple and mild approach to alpha-hydroxyglycine synthesis and derivatization that is compatible with commonly used amino acid protecting groups. Congrats to coauthors Pooja Solanke, Debolina Sarkar, and Pranab Saha! www.biorxiv.org/content/10.6...
biorxiv.org
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TaylorLab-Chembio @taylorlab-chembio.bsky.social · 17/04/2026
Our red-shifted aromatic cation manuscript is now out in @jacs.acspublications.org! Lots of data to unpick, including mechanistic photochem, protein labelling, sensing in live cells, and chemical proteomics. Congrats to coauthors Pranab, Pooja, Sanwayee, and Vishal! pubs.acs.org/doi/10.1021/...
pubs.acs.org
Designer Aromatic Cations for Photoinduced Protein Ligation, Imaging, and Intracellular Labeling at Extended Wavelengths
Photoinduced protein labeling strategies have become essential tools in chemical biology, but most strategies require high-energy wavelengths of light as input to drive reactivity. Recently, we report...
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TaylorLab-Chembio @taylorlab-chembio.bsky.social · 17/02/2026
Check out the final version of our work on photocatalytic protein ligation in @jacs.acspublications.org. Using a matched pair of simple aromatic cations, we show rapid labelling at the peptide, protein, and intracellular level. Great work by Vishal, Hieu, and Sam! pubs.acs.org/doi/abs/10.1...
pubs.acs.org
Cation–Cation Photosensitization for Protein Ligation and Intracellular Catalysis
We report here a photosensitized strategy for protein labeling in which N-substituted pyridinium salts are activated using a 2,4-diaryl-N-methyl quinolinium scaffold. Structure–reactivity relationship...
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TaylorLab-Chembio @taylorlab-chembio.bsky.social · 04/11/2025
Check out our latest preprint in @biorxivpreprint.bsky.social. Like charges usually repel each other, but here we show the right pair of aromatic cations can actually be sensitize each other for protein labelling, even inside a cell. Congrats to Vishal Hieu and Sam! www.biorxiv.org/content/10.1...
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TaylorLab-Chembio @taylorlab-chembio.bsky.social · 17/10/2025
Check out our 2nd preprint of the week! It was a privilege to collaborate with @gustafsonlabsbu.bsky.social to demonstrate that our recently developed radical photocages enable quick and simple photo-induced trifluoromethylation of small molecule organics and API's. chemrxiv.org/engage/chemr...
chemrxiv.org
Facile Trifluoromethylation of Arenes and Heterocycles via a Bench Stable Photocaged Trifluoromethylation Reagent
Herein we report a simple radical aromatic trifluoromethylation process that utilizes a cationic, aromatic sulfonate ester as a trifluoromethyl radical photocage. This chemistry allows for the rapid a...
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Reposted by TaylorLab-Chembio
Gustafson Group @gustafsonlabsbu.bsky.social · 16/10/2025
Check out our latests work in collaboration with @taylorlab-chembio.bsky.social! We evaluated their biomolecular photocaged trifluormethylation reagent on small molecules, finding it effected rapid trifluoromethylation of diverse aromatics, including several APIs. chemrxiv.org/engage/chemr...
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TaylorLab-Chembio @taylorlab-chembio.bsky.social · 15/10/2025
Happy to share our preprint in @biorxivpreprint.bsky.social on designed aromatic cations for photochemical protein ligation. We show intracellular labelling w/ green light, wash-free imaging, and mechanistic insights. Congrats to Pranab, Pooja, Sanwaye, and Vishal! www.biorxiv.org/content/10.1...
biorxiv.org
Designer Aromatic Cations for Photo-Induced Protein Ligation, Imaging, and Intracellular Labelling at Extended Wavelengths
Photo-induced protein labelling strategies have become essential tools in chemical biology, but most strategies require high energy wavelengths of light as input to drive reactivity. Recently, we repo...
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Reposted by TaylorLab-Chembio
Lisa McElwee-White @mcelweewhite.bsky.social · 14/01/2025
Hey Organic Asst Profs coming up for tenure (and your senior colleagues) — it is nomination season for the ACS DOC Young Academic Investigators Symposium. Deadline is Feb. 6, 2025. The website has last year’s date 😳 but the other info is right. #ChemSky www.organicdivision.org/meetingsuppo...
organicdivision.org
Academic Young Investigator's Symposium (YAS) - ACS Division of Organic Chemistry
The Academic Young Investigator's Symposium is for Asst. Prof.'s who are entering their 5th or 6th years and who have not yet been considered for tenure.
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Reposted by TaylorLab-Chembio
Nick Mitchell @mitchellchem.bsky.social · 03/12/2024
I have an AstraZeneca-funded PhD position available (4 years), based in my lab (School of Chemistry, University of Nottingham); start date Oct 2025! Traceless Chemoenzymatic Peptide Synthesis Application deadline: 6 Jan 2025. Get in touch!!! www.findaphd.com/phds/project...
findaphd.com
Traceless Chemoenzymatic Peptide Synthesis at University of Nottingham on FindAPhD.com
PhD Project - Traceless Chemoenzymatic Peptide Synthesis at University of Nottingham, listed on FindAPhD.com
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Reposted by TaylorLab-Chembio
Abhishek Chatterjee @achemsynbio.bsky.social · 01/12/2024
Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing! V1: go.bsky.app/3P5i7nJ V2: go.bsky.app/Cr4ej7
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Thorn-Seshold Lab @thornsesholdlab.bsky.social · 17/11/2024
📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
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TaylorLab-Chembio @taylorlab-chembio.bsky.social · 21/11/2024
What better way to open our acct on bsky than by announcing a new paper! Check out the final version of our pyridinium-ylide alkylation approach for accessing highly bespoke #chembio pyridinium probes in JOC/@amerchemsociety.bsky.social! Congrats to authors Ash and Ben on the great work!
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