iiinova — where your digital self keeps evolving

Reposted by Taylor Head, PhD

American Society of Human Genetics (ASHG) @geneticssociety.bsky.social · 03/09/2026

@mikelove.bsky.social, @rrsharp.bsky.social, & co of @hggadvances.bsky.social's latest article demonstrate that social risk factors confer substantial explanatory power beyond genetic liability alone: bit.ly/4x4qCCC #ASHG #HumanGenetics #GeneticsDiscoveries

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Reposted by Taylor Head, PhD

Sean Bresnahan @seantbres.bsky.social · 31/08/2026

Our new preprint introduces ✨ICONIC✨: an R package making causal inference accessible for observational omics. It unifies genetic instruments (Mendelian randomization) and negative controls (proximal inference) for mediation analysis under unmeasured confounding. www.medrxiv.org/content/10.6...

medrxiv.org

ICONIC: An R Package for Integrating Instrumental Variable- and Negative-Control-Informed Causal Discovery and Diagnostics in Multiomic Studies

Unmeasured confounding threatens causal inference and replicability in observational multi-omic studies across variable environments. Genetic instrumental variables (Mendelian randomization) and negat...

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Reposted by Taylor Head, PhD

Yung-Han (Tina) Chang @ytchang11.bsky.social · 20/05/2026

Congratulations to @taylorhead.bsky.social for her excellent presentation at STATGEN 2026! She is developing methods for isoform-level fine-mapping in TWAS using long-read-informed priors.💻

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Taylor Head, PhD @taylorhead.bsky.social · 19/05/2026

Congratulations to @ytchang11.bsky.social for her great presentation today at STATGEN on formal statistical replication analysis in lung cancer GWAS! 🧬

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Taylor Head, PhD @taylorhead.bsky.social · 06/05/2026

Shout-out to @seantbres.bsky.social who will be presenting some really interesting work at #bog26 this evening! Using long-read, isoform-resolved placental transcriptomics, this work shows how PFAS exposure impacts placental transcriptional networks and imprinting (poster #70)

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Taylor Head, PhD @taylorhead.bsky.social · 06/05/2026

Excited to present a poster at #bog26 this evening starting at 7:30pm! Come by poster #108 to learn about some motivating and preliminary work on a novel method to fine-map causal isoforms in TWAS leveraging tissue-specific long-read RNA-seq evidence.

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Reposted by Taylor Head, PhD

Arjun Bhattacharya @arjunbhattac.bsky.social · 26/03/2026

Another preprint from our group @mdanderson.bsky.social led by talented postdoc @seantbres.bsky.social! Joint with @jonhuang.bsky.social, exploring the intersection of environmental toxins, maternal/fetal health, and placental txomics. Tweet thread below!

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Taylor Head, PhD @taylorhead.bsky.social · 24/03/2026

New preprint on the genetic regulation of isoform expression and breast cancer risk! TL;DR: tissue-specific, long-read transcript annotations shape eQTL mapping, TWAS, and isoforms we prioritize at GWAS loci. @arjunbhattac.bsky.social www.biorxiv.org/content/10.6...

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