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Tantillo Group

@tantillogroup.bsky.social
24 followers 0 following 11 posts

Student-run account for the Tantillo Group: blueline.ucdavis.edu

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Tantillo Group @tantillogroup.bsky.social · 17/09/2026
Exploring the Generality of Post-Transition State Bifurcations for Metal-Catalyzed C–H Insertion Reactions that Form 4-Membered Rings doi.org/10.1021/acs....
doi.org
Exploring the Generality of Post-Transition State Bifurcations for Metal-Catalyzed C–H Insertion Reactions that Form 4-Membered Rings
Abstract. Post-transition state bifurcations (PTSBs) previously have been identified in dirhodium-catalyzed C–H insertion reactions that form β-lactones, w
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Tantillo Group @tantillogroup.bsky.social · 08/09/2026
Deconstruction of lysergic acid diethylamide doi.org/10.1073/pnas...
doi.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Tantillo Group
Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · 08/09/2026
#UCDavisIPN Director @deolsonlab.bsky.social , affiliates @tantillogroup.bsky.social and Oliver Fiehn, and their teams just published a new study in @pnas.org deconstructing the ergoline core of LSD. Read the study: www.pnas.org/doi/10.1073/...
pnas.org
Deconstruction of lysergic acid diethylamide | PNAS
Of the classic psychedelics, lysergic acid diethylamide (LSD) is perhaps the best-known, but its complex chemical architecture has limited syntheti...
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Tantillo Group @tantillogroup.bsky.social · 20/08/2026
Stereocontrolled entry to borylated piperidines via stepwise dearomative carboboration of pyridines doi.org/10.1039/D6SC...
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Reposted by Tantillo Group
Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · 30/07/2026
#UCDavisIPN Affiliates @tantillogroup.bsky.social and @shawshankrxn.bsky.social published a new way to build chiral aromatic 5-membered heterocycles, unlocking potential for replacing flat heteroarenes with tetrahedral stereogenic centers. Find out why it matters for #medicinalchemistry:
cen.acs.org
Reaction rounds up atoms into unusual cyclic compounds
Chiral aromatic heterocycles could be novel motifs in drug candidates
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Tantillo Group @tantillogroup.bsky.social · 30/07/2026
A Rhodium-Catalyzed Cyclization of Sulfonimidamides and Sulfondiimidamides: Synthesis and Exploration of Chiral Aromatic Heterocycles doi.org/10.1021/jacs...
doi.org
A Rhodium-Catalyzed Cyclization of Sulfonimidamides and Sulfondiimidamides: Synthesis and Exploration of Chiral Aromatic Heterocycles
Abstract. Although cyclic SIAs have demonstrated promising medicinal potential, methodologies for their construction remain relatively scarce. SIAs have pr
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Tantillo Group @tantillogroup.bsky.social · 14/07/2026
Toward the Synthesis of Pestalustaine A: Structural Revision and Formation of Original Strained Tricyclic Architectures doi.org/10.1002/anie...
doi.org
Toward the Synthesis of Pestalustaine A: Structural Revision and Formation of Original Strained Tricyclic Architectures
Our synthetic endeavor toward the total synthesis of the reported unprecedented tricyclic skeleton of the sesquiterpene pestalustaine A allowed us to perform divergent cyclizations of a bicyclo[4.4.1...
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Tantillo Group @tantillogroup.bsky.social · 11/07/2026
Strain-Release Pentafluorosulfanylation of Carbonyl-Containing Disubstituted Bicyclobutanes: A Fortuitous Path to SF5-Containing Oxa[2.1.1]bicyclohexanes doi.org/10.1002/anie...
doi.org
Strain‐Release Pentafluorosulfanylation of Carbonyl‐Containing Disubstituted Bicyclobutanes: A Fortuitous Path to SF<sub>5</sub>‐Containing Oxa[2.1.1]bicyclohexanes
A regio- and diastereoselective method for strain-release pentafluorosulfanylation of carbonyl-containing 1,3-disubstituted [1.1.0]bicyclobutanes (BCBs) was developed that led to several fortuitous d...
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Tantillo Group @tantillogroup.bsky.social · 30/05/2026
The One Ring: A Monocycle Producing Class II Diterpene Cyclase from Isodon leucophyllus doi.org/10.1021/jacs...
doi.org
The One Ring: A Monocycle Producing Class II Diterpene Cyclase from Isodon leucophyllus
Class II diterpene cyclases (DTCs) have long been recognized to mediate distal cyclization of geranylgeranyl pyrophosphate (GGPP) into bicyclic labdane-related products through an acid–base catalytic ...
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Reposted by Tantillo Group
Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 08/05/2026
Don't miss in our latest issue research by @tantillogroup.bsky.social, T. Andrew Mitchell & co. @illinoisstateu.bsky.social investigating a unified reaction pathway of thermal & TBSOTf-mediated oxidopyrylium-alkene (5+2) cycloadditions #orgchem Check it out here👇
pubs.rsc.org
Investigations toward a unified reaction pathway of thermal and TBSOTf-mediated oxidopyrylium-alkene (5 + 2) cycloadditions
Oxidopyrylium-based (5 + 2) cycloadditions are crucial reactions to construct seven-membered carbocycles containing an ether bridge (i.e. oxabicyclo[3.2.1]octanes). Intramolecular…
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Tantillo Group @tantillogroup.bsky.social · 18/04/2026
Ab Initio Molecular Dynamics Simulations for Organic Chemists─It is About Time! doi.org/10.1021/jacs...
doi.org
Ab Initio Molecular Dynamics Simulations for Organic Chemists─It is About Time!
Molecular dynamics simulations model chemical reactions as continuous changes in molecular structure over time instead of static minima and transition states. This perspective argues that time-depende...
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Tantillo Group @tantillogroup.bsky.social · 08/03/2026
Catalytic & Enantioselective Ring Opening of Azabicyclo[1.1.0]Butyl Carbinols via N-Allylation of Strained Tertiary Amines doi.org/10.1002/anie...
doi.org
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Tantillo Group @tantillogroup.bsky.social · 20/02/2026
Construction of Potential Energy Surfaces for Reactions With Post-Transition State Bifurcations Using Principal Component Analysis doi.org/10.1002/jcc....
doi.org
Construction of Potential Energy Surfaces for Reactions With Post‐Transition State Bifurcations Using Principal Component Analysis
A method for constructing potential energy surfaces (PESs) for reactions with post-transition state bifurcations based on principal component analysis (PCA) is described and its utility is illustrate...
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Tantillo Group @tantillogroup.bsky.social · 20/02/2026
On the Discorhabdins Leading to the Aleutianamine Ring System: A One-Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology doi.org/10.1002/anie...
doi.org
On the Discorhabdins Leading to the Aleutianamine Ring System: A One‐Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology
The thiocarbenium ion rearrangement of 3-dihydrodisorhabdin B greatly increases the recovery of aleutianamine from Latrunculia spp., a pyrroloiminoquinone natural product with potent activity against...
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