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Tamas Lazar

@tamaslazar.bsky.social
158 followers 291 following 33 posts

Asst. prof. @VUBrussel.bsky.social | Senior PostDoc @Bio2Byte.bsky.social in computational biology, structural bioinformatics and AI development. | Member of @JongeAcademie.bsky.social

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Tamas Lazar @tamaslazar.bsky.social · 10/09/2026
📄 For those interested in #IDPs, #modeling and #simulation of ensembles, biomolecular #condensates, their disease relevance, and designed synthetic #LLPS applications: Our new review is now available in Curr Opin Struct Biol 🎉 🔗 Free access for the next 50 days: authors.elsevier.com/c/1nlQt,LqAr...
Experiments (NMR, SAXS, FRET, EPR spectroscopy) and simulation, as well as generative AI enables integrative modeling of IDP conformational ensembles. However these ensembles need to be evaluated, filtered and compared against each other other. Besides monomeric state simulation, multi-copy simulation can also reproduce condensation-type droplet formation (usually coarse-grained MD or Monte Carlo simulation) and this enables to map out an LLPS phase diagram.
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Tamas Lazar @tamaslazar.bsky.social · 01/09/2026
International postdocs are welcomed to apply for interdisciplinary research positions as #MSCA fellows @vubrussel.bsky.social. If you are interested in computational protein science, contact me in email for supervision. Or find other Life Sci. supervisors here: interact-programme.be/vub-supervis...
interact-programme.be
VUB supervisors
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Tamas Lazar @tamaslazar.bsky.social · 21/07/2026
Onmisbare lectuur van onze organisatie Jonge Academie (@jongeacademie.bsky.social) in De Tijd (@tijd.be) over de rol van sociale en humane wetenschappen in AI-tijden. 👇 #AI #LLM #wetenschap #onderzoek #onderwijs #hogeronderwijs #STEM #SSH #studiekeuze #beleid
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Tamas Lazar @tamaslazar.bsky.social · 20/04/2026
Happy to re-share Giacomo Pedrelli's paper published in PNAS with contributions from a few of us from the Vorobieva lab: "Negative design enables cell-free expression and folding of designed transmembrane β-barrels" #proteindesign #denovodesign #nanopores #TMBs #OMPs #porins #membraneproteins
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Tamas Lazar @tamaslazar.bsky.social · 12/04/2026
"Negative design enables cell-free expression and folding of designed transmembrane β-barrels" published in @pnas.org
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Tamas Lazar @tamaslazar.bsky.social · 10/02/2026
Honoured to be selected as a new member of the Jonge Academie! 🎓 I look forward to contributing to science & tech policy through surveys and stakeholder consultations. I’m also eager to leverage international networks to shape a fair, safe, and sustainable future for academia in Belgium & Europe 🇧🇪 🇪🇺
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Reposted by Tamas Lazar
Peter Head @peterheadcbe.bsky.social · 03/02/2026
This research paper is the first time that a tipping point of a switch from a carbon sink to a carbon emission source in tropical rainforests has been identified clearly – not just for one year but for the last 20 years. Cause is a change in the local climate. www.theguardian.com/environment/...
theguardian.com
Australian tropical rainforest trees switch in world first from carbon sink to emissions source
Researchers say carbon emissions change in Queensland tropical rainforests may have global climate implications
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Tamas Lazar @tamaslazar.bsky.social · 02/02/2026
I'm excited to announce that from today I will work in the @bio2byte.bsky.social research group at the (IB)2 ULB-VUB Interuniversity Institute for Bioinformatics and @vubrussel.bsky.social DBIT-SBB as a Senior Postdoctoral Researcher.
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Tamas Lazar @tamaslazar.bsky.social · 22/01/2026
Excited to share our latest work on tandem #SH3 binding among the p47phox-related proteins. We define the optimal binding preference of tandemly arranged SH3 domains and propose new #motif instances. Structure predictions suggest the possibility of a reverse binding mode for certain #SLiM instances.
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Tamas Lazar @tamaslazar.bsky.social · 22/01/2026
Catching up after not being too active recently: In one of our most #interdisciplinary #multimodal research articles published last year, we demonstrated that #LLPS #condensate dysregulation is very widespread in somatic #cancer. We also provided mechanistic explanations for #oncofusion #proteins.
doi.org
Phase-separating fusion proteins drive cancer by upsetting transcription regulation - Genome Biology
Background Numerous cellular processes rely on biomolecular condensates formed through liquid–liquid phase separation (LLPS). Recently, it has become evident that somatic mutations can interfere with ...
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Reposted by Tamas Lazar
Nature Reviews Drug Discovery @natrevdrugdiscov.nature.com · 09/06/2025
Targeting protein disorder: the next hurdle in drug discovery www.nature.com/articles/s41... rdcu.be/eqaY3 Intrinsically disordered proteins are often dysregulated in disease, but have been considered ‘undruggable’. This new Review discusses approaches that could tackle this barrier
Targeting disordered proteins
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Tamas Lazar @tamaslazar.bsky.social · 09/06/2025
🚨 New Review in @natrevdrugdiscov.nature.com! We reviewed how to #drug intrinsically disordered proteins ( #IDPs) 🧬 Among many others, we touch upon: 🧪 IDP modulators (i-mods) in clinical trials; 🔬 Exp.+comp. synergy; 🚀 A path forward to target IDPs 📖 Read more: doi.org/10.1038/s41573-025-01220-6
doi.org
Targeting protein disorder: the next hurdle in drug discovery - Nature Reviews Drug Discovery
Intrinsically disordered proteins are frequently dysregulated in many diseases, but because of their heterogeneous, highly dynamic structural states they have been considered largely ‘undruggable’ by ...
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Tamas Lazar @tamaslazar.bsky.social · 01/03/2025
I cannot access #PubMed or #PubChem. Are they down???
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Tamas Lazar @tamaslazar.bsky.social · 05/12/2024
In #China, the #publication #retractation rate is ~10x higher than 5 years ago. 😮 Some of the reasons why this is happening are well-understood. 📰 Source: journals.plos.org/plosone/arti...
From 2012 to 2019, the retraction rate was relatively stable, with an average retraction rate of 0.10%. However, the retraction rate rose sharply after 2019 and reached 0.53% in 2023, and the growth rate of retracted articles (91.92%) outpaced the growth rate of published papers (32.3%) during 2019–2023
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Tamas Lazar @tamaslazar.bsky.social · 05/12/2024
Our latest #C9orf72 ALS paper is out demonstrating biomolecular #condensation of #G3BP1 driven by R-DPRs: 📰 C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1 🔬 www.pnas.org/doi/10.1073/... #neurodegeneration #MND #ALS #endALS #FTD #LLPS
pnas.org
C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1 | PNAS
The toxic effects of C9orf72-derived arginine-rich dipeptide repeats (R-DPRs) on cellular stress granules in amyotrophic lateral sclerosis (ALS) an...
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Tamas Lazar @tamaslazar.bsky.social · 04/12/2024
Hello #Bluesky 👋 After the golden age of #Twitter, I'm noticing that the scientific community has been moving here, so I'll also post things here besides my #X profile: x.com/LazTamas 💬 I'll follow discussions on #proteinengineering #AI #TMBs #OMPs #IDPs #LLPS #condensates #neurodegeneration #ALS
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