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Synlett Journal @synlettjournal.bsky.social · 9h

🧬 Unlocking new ways to modify #nucleosides! Rambabu Dandela & co-workers highlight transition-metal-catalyzed C–H activation strategies for the #functionalization of valuable nucleoside scaffolds🔬 #purines 👉 buff.ly/ZPMv8v6

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Synlett Journal @synlettjournal.bsky.social · 12/10/2026

How can #cobalt #catalysis enable the asymmetric synthesis of challenging chiral #amides? Wenyu Zhao & Yifeng Chen report a cobalt-catalyzed asymmetric carbamoyl addition to imines, giving α,α-disubstituted α-amino amides with excellent enantioselectivity✨ 👉 buff.ly/ne3Qgfy

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Synlett Journal @synlettjournal.bsky.social · 09/10/2026

💡How can visible light generate #carbocations under mild conditions? Ho, Bissember, Pagire & co-workers highlight recent advances in visible-light-driven carbocation generation, exploring radical–polar crossover and mesolytic cleavage pathways⚡ #photocatalysis 👉 buff.ly/TJFow6c

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Reposted by Synlett Journal

Nobel Prize @nobelprize.org · 07/10/2026

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2026 #NobelPrize in Chemistry to Henri B. Kagan and Kenso Soai “for the discovery of non-linear effects and autocatalysis in asymmetric organic synthesis.”

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Synlett Journal @synlettjournal.bsky.social · 07/10/2026

👋 Meet the team behind SYNLETT This week, we're featuring our Associate Editor Monika Raj✨ Based at Emory University, her research focuses on chemical probes, #bioconjugation, and selective modification of #peptides and #proteins. 👀 Who's next? Meet another editor in 2 weeks! buff.ly/li6XiJv

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Synlett Journal @synlettjournal.bsky.social · 05/10/2026

💡Can visible light rewrite the reactivity of α,β-unsaturated ketones? Erik Romero & co-workers reveal a step- and atom-efficient transposition of olefin functional groups using a fluorophore and phosphine catalyst 🔬✨ #photocatalysis #organocatalysis 👉 buff.ly/wKnC1RE

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Synlett Journal @synlettjournal.bsky.social · 02/10/2026

⚡️ Need a faster route to highly substituted benzoic acids? Alessandro Palmieri & co-workers present a one-pot, microwave-assisted synthesis from 7-oxo-4-nitroesters under Lewis acid catalysis🔥 #nitroalkanes 👉 buff.ly/SEdILBQ

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Synlett Journal @synlettjournal.bsky.social · 30/09/2026

Hiroyuki Morimoto & co-workers investigate functional group tolerance in #CuAAC using a functional group evaluation kit🧪 The study highlights the importance of ligand selection and shows how switching to SPAAC can overcome thiol-induced reactivity issues⚡ #azides #triazoles 👉 buff.ly/hzkQLNK

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Synlett Journal @synlettjournal.bsky.social · 28/09/2026

How does linker length shape biological activity? Makoto Furutachi & co-workers explore methylene-linked #homodimers across diverse scaffolds, revealing scaffold-dependent effects on antiviral, cytotoxic, and antiproliferative activities🧪 👉 buff.ly/tyGvmN5

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Synlett Journal @synlettjournal.bsky.social · 25/09/2026

#Microflow chemistry enables precise control over #oligopyrrole synthesis!⚗️ Discover how Takuya Kurahashi & co-workers tuned product distributions, improved the synthesis of pentapyrrins, and reduced solvent consumption📖 👉 buff.ly/u66PFt7

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Synlett Journal @synlettjournal.bsky.social · 23/09/2026

👋 Meet the team behind SYNLETT This week, we're featuring our Associate Editor David A. Nicewicz ✨ Based at UNC Chapel Hill, his research focuses on #photoredox #catalysis, radical chemistry, and organic #photocatalysts. 👀 Who's next? Meet another editor in 2 weeks! buff.ly/nyG38Wx

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Synlett Journal @synlettjournal.bsky.social · 21/09/2026

Discover a photo-driven strategy for the #enantioselective synthesis of 3,4-dihydroisoquinolones!💡Read how Kaiwu Dong & co-workers achieve high regio- and enantioselectivity through #radical cation chemistry🧪 #amination 👉 buff.ly/Wirhhev

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Synlett Journal @synlettjournal.bsky.social · 18/09/2026

⚗️ New structural insights into (o-carboran-1-yl)lithium! From monomers to dimers and polymers, discover how ether ligands shape these key synthetic intermediates in the latest work by Yoichi Hoshimoto & co-workers 📖 #carborane #OpenAccess 👉 buff.ly/HWGpsO9

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Synlett Journal @synlettjournal.bsky.social · 16/09/2026

Join Thieme #Cheminar “Alkynes in Organic Synthesis” 🔬 featuring Profs. Johannes Teichert 🇩🇪 @teichertlab.bsky.social, Gwilherm Evano 🇧🇪 & Antonio M. Echavarren 🇪🇸, chaired by Prof. Manuel van Gemmeren 🇩🇪 @vangemmerenlab.bsky.social 📅 September 24, 2026 ⏰ 2 PM (CEST) Sign up today 👉 buff.ly/X7YOcmF

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Synlett Journal @synlettjournal.bsky.social · 16/09/2026

🧪 Beyond carbon! Discover how #sulfur oxidation-state editing is redefining late-stage #functionalization, unlocking new strategies for selective molecular diversification⚗️ Read the latest Prespective by Amit Bhowmik & Kate Carroll #umpolung 👉 buff.ly/JLkYt4I

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Synlett Journal @synlettjournal.bsky.social · 14/09/2026

How reproducible is your reaction yield?📊 Bloodworth, Perry @perrychem.bsky.social & co-workers propose a simple framework for reporting yields with confidence intervals, bringing greater transparency and reliability to synthetic chemistry📈 #reproducibility #OpenAccess 👉 buff.ly/Qz2C2kM

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Synlett Journal @synlettjournal.bsky.social · 11/09/2026

Discover a mechanochemical Pd/S,O-ligand-catalyzed C–H #arylation of #anisole derivatives that minimizes HFIP, uses the arene as the limiting reagent, and enables efficient biaryl synthesis by Bjelopetrović & Ángeles Fernández-Ibáñez🌱 #mechanochemistry #OpenAccess 👉 buff.ly/MQXEOyB

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Synlett Journal @synlettjournal.bsky.social · 09/09/2026

👋 Meet the team behind SYNLETT This week, we're featuring our Associate Editor Ang Li ✨ Based at the Shanghai Institute of Organic Chemistry, his research focuses on #TotalSynthesis, #NaturalProducts, and synthetic methodology. 🧪 Who's next? Next editor in 2 weeks! buff.ly/xBz4Y4h

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Reposted by Synlett Journal

Perry Group @perrychem.bsky.social · 07/09/2026

Great to see our collaboration with @psdi-uk.bsky.social published in @synlettjournal.bsky.social. We hope this contributes to discussions on reproducibility in organic synthesis. Well done to all involved, particularly Grace and Jazmine who led some of this work during their undergraduate degrees.

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Synlett Journal @synlettjournal.bsky.social · 07/09/2026

🧪Amide synthesis, reimagined! Discover how Liu & Huang overcome long-standing challenges in #hydroaminocarbonylation through "basicity masking," enabling atom-economical access to amides and N-heterocycles with remarkable selectivity✨ #catalysis 👉 buff.ly/gcDZB7I

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Synlett Journal @synlettjournal.bsky.social · 04/09/2026

Unlock the potential of #housanes 🏠 Discover a palladium-catalyzed strategy to access these highly strained bicyclo[2.1.0]pentanes and tune product selectivity through ligand design in the latest paper by Sidney Wilkerson-Hill & co-workers #palladium #catalysis #OpenAccess 👉 buff.ly/cabO43y

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Synlett Journal @synlettjournal.bsky.social · 02/09/2026

⚗️Chiral #dihydrobenzofurans in up to 99% yield and 85% ee! Discover the catalytic asymmetric #iodoetherification strategy and its application to triazole-functionalized products in the latest letter by Takayoshi Arai & co-workers🧪 👉 buff.ly/CNPdWmG

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Synlett Journal @synlettjournal.bsky.social · 31/08/2026

Takuya Kurahashi & co-workers develop a recyclable polystyrene-supported 4CzIPN #photocatalyst with enhanced stability♻️, enabling a range of visible-light-driven transformations while advancing more sustainable #photoredox chemistry💡 👉 buff.ly/fa15hsT

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Synlett Journal @synlettjournal.bsky.social · 28/08/2026

Vasudevan Dhayalan reviews the latest (2020–2025) advances in dual organo/photocatalysis, highlighting greener, step-economical strategies for carbonyl functionalization and late-stage functionalization of bioactive molecules💡 👉 buff.ly/dPP6xrB

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Synlett Journal @synlettjournal.bsky.social · 26/08/2026

👋 Meet the team behind SYNLETT This week, we're spotlighting our Associate Editor Tanja Gulder ✨ Based at the University of Leipzig, her research focuses on #NaturalProduct biosynthesis, #biocatalysis, and synthetic biology. 👀 Who's next? Meet another editor in 2 weeks! buff.ly/xBz4Y4h

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Synlett Journal @synlettjournal.bsky.social · 24/08/2026

Sungwoo Hong & co-workers showcase a clever strategy for bicyclo[1.1.0]butane (BCB) #oxygenation using stabilized oxene #surrogates, unlocking access to 5-oxa-2-oxo-BCHex scaffolds—promising 3D #bioisosteres for medicinal chemistry💊 👉 buff.ly/TZporDX

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Synlett Journal @synlettjournal.bsky.social · 21/08/2026

📖Discover this Account by Harada & Nishida on the development of #lanthanide catalyzed enantioselective #DielsAlder reactions, enabling asymmetric cycloadditions of acid-labile siloxydienes✨ #Danishefsky 👉 buff.ly/mdpDVgu

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Synlett Journal @synlettjournal.bsky.social · 19/08/2026

💡A new twist on the Norrish–Yang photocyclization! Sophie Rousseaux & co-workers unlock efficient access to 1-aryl cyclopropanols through a clever triplet-state strategy⚗️ #photocyclization #cyclopropanol 👉 buff.ly/jrKYiLr

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Synlett Journal @synlettjournal.bsky.social · 17/08/2026

🍬Expanding the toolbox for rare sugar synthesis! Ping & Kong introduce a photo-HAT/nickel dual-catalytic strategy for direct, stereoselective C(sp³)–H functionalization of carbohydrates, enabling efficient access to C- #glycosides, branched-chain sugars, and -carbasugars✨ 👉 buff.ly/khrCBKo

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Synlett Journal @synlettjournal.bsky.social · 14/08/2026

🌱A practical route to sustainable #nitroarene reduction! Jagankar & Maity @o-matselab.bsky.social report a recyclable Ag nanoparticle hydrogel catalyst delivering rapid conversions in water with minimal NaBH₄💧 #GreenCatalysis 👉 buff.ly/Vqa7L9v

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Synlett Journal @synlettjournal.bsky.social · 12/08/2026

👋 Meet the team behind SYNLETT Today we're introducing Matthew Gaunt, Associate Editor✨ A pioneer in C–H #functionalization, catalytic reaction development, and complex molecule synthesis at @cam.ac.uk 🧪 👀 Who's next? Meet another editor in 2 weeks! buff.ly/xBz4Y4h

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Synlett Journal @synlettjournal.bsky.social · 10/08/2026

Breaking barriers in Cu-catalyzed cross-coupling! Wang, Chen & Liu report a mild #copper catalyzed C(sp³)–C/N coupling of unactivated alkyl halides, enabled by amide-derived anionic N,N,N-ligands🧪 #radical 👉 buff.ly/HrUhh2T

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Synlett Journal @synlettjournal.bsky.social · 07/08/2026

🧪✨ Building the previously unknown #oxazabenzocyclooctaindenes is now a reality! Langer & co-workers combine #SuzukiMiyaura coupling, C–O coupling, and Pd-catalyzed C–H activation to efficiently construct challenging eight-membered ring systems⚙️ #catalysis 👉 buff.ly/rZuYBMx

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Synlett Journal @synlettjournal.bsky.social · 05/08/2026

🔬 Explore advances in #cycloaddition chemistry through ketenimine #DielsAlder reactivity, in a Perspective by Liss & Newton📚, highlighting heteroatom-containing cycloaddition partners inspired by #ketene chemistry and their potential as highly reactive aza-dienophiles🧪 👉 buff.ly/cbeFYWo

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Synlett Journal @synlettjournal.bsky.social · 03/08/2026

Explore a convergent synthetic strategy toward methyl peracetyl hikosaminide, reported by Fujino & Inoue📚, featuring radical–radical #CrossCoupling and a redesigned intermolecular radical addition to aldehydes that improves selectivity and efficiency🚀 #hikizimycin 👉 buff.ly/tJTRlDy

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Synlett Journal @synlettjournal.bsky.social · 31/07/2026

#Azides meet #enolates! Li & Furkert introduce a straightforward method to form novel #triazenes via nucleophilic addition and electrophilic trapping✨ #cycloaddition 👉 buff.ly/jbfWBEg

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Synlett Journal @synlettjournal.bsky.social · 29/07/2026

👋 Meet the team behind SYNLETT Today we're introducing Rubén Martín, Associate Editor✨ A leader in #CrossCoupling chemistry, metal catalysis, and C–C bond activation at ICIQ, his research is expanding the frontiers of organic synthesis 🧪 Who's next? Next editor in 2 weeks! buff.ly/keEY1uU

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Synlett Journal @synlettjournal.bsky.social · 27/07/2026

Kenta Tanaka & co-workers review recent advances in #sulfur containing salt-based organophotoredox catalysts, highlighting their strong oxidative power and broad reactivity in reductive quenching cycles🧪 #thioxanthylium 👉 buff.ly/lu0J6ee

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Synlett Journal @synlettjournal.bsky.social · 24/07/2026

Dual #functionalization unlocked! Yoichi M. A. Yamada & co-workers report a visible-light #photocatalytic trifluoromethyl carboxylation of #enamides using CF₃SO₂Na and CO₂ 🧪🌿 #radical #trifluoromethylation 👉 buff.ly/VukniiE

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Synlett Journal @synlettjournal.bsky.social · 22/07/2026

Expanding C(sp³) incorporation via #cobalt #catalysis! This Account by L. Reginald Mills & co-workers highlights #Negishi C(sp²)–C(sp³) #CrossCoupling of redox-active alkyl electrophiles, enabling access to pharmaceutically relevant scaffolds🌿 👉 buff.ly/DPOdNSy

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Synlett Journal @synlettjournal.bsky.social · 20/07/2026

From reactive to controllable⚡Dawson Konowalchuk & co-workers introduce an iterative #functionalization approach for heavily substituted cyclobutenes, enabling selective #SuzukiMiyaura arylation of strained rings🧪 #CrossCoupling 👉 buff.ly/aTjB1et

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Synlett Journal @synlettjournal.bsky.social · 17/07/2026

#Gold catalysis meets peptide-based #organocatalysis! Zhou, Wang & co-workers develop a relay catalytic system for the enantioselective synthesis of chiral #azepines via a cascade 1-aza-Cope rearrangement ✨ #PBPS 👉 buff.ly/4tCwHP8

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Synlett Journal @synlettjournal.bsky.social · 15/07/2026

New access to unsymmetrical 2-azapyrenes⚗️ Langer & co-workers report a Brønsted acid–mediated alkyne–carbonyl #metathesis strategy to build these previously unknown polycyclic scaffolds✨ #palladium #CrossCoupling 👉 buff.ly/IljnmuF

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Synlett Journal @synlettjournal.bsky.social · 13/07/2026

New bioinspired route to C- #glycosides 🍬 Sun & He report a protecting-group-free strategy combining the #Petasis (borono–Mannich) reaction with SN2-type deaminative cyclization to directly transform unprotected aldoses into stereoselective C-glycosides🔬 👉 buff.ly/zJ6PQL3

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Synlett Journal @synlettjournal.bsky.social · 10/07/2026

From computation to catalyst discovery! Mita & co-workers combine photoexcited Pd catalysis with #VLAS to identify ligands that suppress back-electron transfer and enable alkyl ketyl #radical formation🧪 #palladium #ketones 👉 buff.ly/LegbZww

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Synlett Journal @synlettjournal.bsky.social · 08/07/2026

👋Meet the team behind SYNLETT Today we're introducing Debabrata Maiti @debabratamaiti.bsky.social, Editor-in-Chief✨ A pioneer in C–H functionalization at IIT Bombay, his research is advancing sustainable synthetic methodologies 🧪Who's next? Next editor in 2 weeks! buff.ly/keEY1uU #MeetTheEditors

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Synlett Journal @synlettjournal.bsky.social · 06/07/2026

New NMR approach for complex fluorinated systems🔬 David Nicewicz & co-workers use J-resolved 2D #NMR with shaped pulse broadband ¹⁹F decoupling to clearly resolve ¹³C–¹⁹F coupling patterns—even up to 274 Hz📊 A powerful way to visualize challenging polyfluorinated compounds. 👉 buff.ly/2CVD7Ng

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Synlett Journal @synlettjournal.bsky.social · 03/07/2026

🧪An overlooked gem in synthesis? Qian & Gui highlight the untapped potential of #sitolactone —a cheap, commercially available chiral building block with major promise for natural product synthesis🌿 Despite its value, it has featured in only a handful of #TotalSynthesis 👉 buff.ly/ppWNWYK

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Synlett Journal @synlettjournal.bsky.social · 01/07/2026

Divergent synthesis made simple🔬 Lei, Huang & co-workers demonstrate that #solvent choice alone can control the formation of α- or β-amino acids in a #rhodium catalyzed reaction🧪 A powerful strategy for efficient access to valuable bioactive compounds. 👉 buff.ly/pMA9Omq

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