During high-intensity exercise a lactic-acidosis occurs with raised myoplasmic and plasma concentrations of lactate− and protons ([lactate−], [H+] or pH). We critically evaluate whether this causes/co...

The skeletal muscle interstitial space is the extracellular region around myofibers and mediates cross-talk between resident cell types. We applied a proteomic workflow to characterize the human skele...

The gradual deterioration of physiological systems with ageing makes it difficult to maintain skeletal muscle mass (sarcopenia), at least partly due to the presence of ‘anabolic resistance’, resultin...