Somatic mutations in DNMT3A and TET2 are common in age-related clonal haematopoiesis and hematopoietic neoplasms. Here, the authors show that loss of TET2, unlike DNMT3A, makes cells more sensitive to...

SNF2-family DNA translocases, a large family of ATPases, have poorly defined roles in genomic stability. In a recent study, Feng et al. identified a synthetic lethal interaction between the SNF2 trans...