Sign in

Sudarshan Rajagopal

@sudarrajagopal.bsky.social
181 followers 370 following 15 posts

Associate Professor of Medicine at Duke University School of Medicine. GPCR signaling and pulmonary vascular disease. Views my own.

PostsRepliesMedia
Reposted by Sudarshan Rajagopal
Ted Pavlic (he/him/his) @tedpavlic.bsky.social · 08/06/2025
Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪 www.richmondscientific.com/how-a-discov...
richmondscientific.com
How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific
A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.
221230516
Reposted by Sudarshan Rajagopal
Senator Patty Murray @murray.senate.gov · 02/05/2025
NIH's work saves lives—& Trump is gutting it. Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries. We ALL need to speak up to save it.
29734191
Sudarshan Rajagopal @sudarrajagopal.bsky.social · 09/04/2025
Excited to share work led by Preston Anderson and Peng Xiao in collaboration with Jinpeng Sun (just like old times when we were postdocs in Lefko lab). We find that beta-arrestins form biomolecular condensates to regulate GPCR function - www.biorxiv.org/content/10.1...
biorxiv.org
β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function
G protein-coupled receptors (GPCRs) are the largest class of receptors in the genome and control many signaling cascades essential for survival. GPCR signaling is regulated by β-arrestins, multifuncti...
2154
Reposted by Sudarshan Rajagopal
Cynthia Wolberger @cwolberger.bsky.social · 21/03/2025
Wow. This is really stunning . www.science.org/doi/10.1126/...
science.org
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
1558
Reposted by Sudarshan Rajagopal
David Malakoff @davidmalakoff.bsky.social · 08/02/2025
NEW: NIH slashes overhead payments for research, sparking outrage | Science | AAAS www.science.org/content/arti...
science.org
NIH slashes overhead payments for research, sparking outrage
Move to cut indirect cost rate to 15% could cost universities billions of dollars
187
Reposted by Sudarshan Rajagopal
Thiago Carvalho @cyrilpedia.bsky.social · 02/02/2025
'Speeds things up, you know. Move fast and break things, amIright? Problem is, in biomedicine some of the things you break are human beings.' @dereklowe.bsky.social www.science.org/content/blog...
science.org
Killing Cancer Patients (Once the Payments Clear)
03717
Reposted by Sudarshan Rajagopal
Pearl Freier @pearlf.bsky.social · 30/01/2025
Merck stopped the Phase 3 Hyperion trial of its pulmonary arterial hypertension (PAH) treatment Winrevair early due to strong efficacy data & fiercepharma.com/pharma/effic... all study participants will be offered access to the drug. #biosky 1/n
153
Reposted by Sudarshan Rajagopal
Carl Zimmer @carlzimmer.com · 28/01/2025
American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12
5718171133
Reposted by Sudarshan Rajagopal
Jeremy Berg @jeremymberg.bsky.social · 23/01/2025
Started off this morning emailing my Senators and Congressman about the NIH and the potential damage being done by unnecessary disruptions. They need to hear from us loud and clear. Constituents matter to them as one of the primary purposes of a politician is to get re-elected (and its their job).
11311129
Reposted by Sudarshan Rajagopal
Jeremy Berg @jeremymberg.bsky.social · 17/01/2025
Bluetorial: When the leadership of Science magazine does not seem to care about getting the facts right in a news story... A very troubling incident occurred some years ago and I think the concerns and lessons are important. My apologies for the length, but it is a complicated story.
media.tenor.com
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
911541
Reposted by Sudarshan Rajagopal
Lauren Slosky @laurenslosky.bsky.social · 22/11/2024
Can we design allosteric modulators that change a GPCR's preferred G protein? Yes!💥 BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design. The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209 🧵👇
doi.org
Design of allosteric modulators that change GPCR G protein subtype selectivity
G protein-coupled receptors (GPCRs), the largest family of drug targets, can signal through 16 subtypes of Gα proteins. Biased compounds that selectively activate therapy-relevant pathways promise to ...
77820
Reposted by Sudarshan Rajagopal
Denis Wirtz @deniswirtz.bsky.social · 24/11/2024
We have updated and expanded our database of fellowships for POSTDOCS in neuroscience/neurology/cog science. For each fellowship, we provide a description, $ amount, deadline, link, and eligibility criteria. Download our database freely here: research.jhu.edu/rdt/funding-... pic.x.com/eEhXhlOzEj
28048