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Stuart Buck

@stuartbuck.bsky.social
3.1K followers 213 following 6.1K posts

Executive Director, Good Science Project

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Reposted by Stuart Buck
Chris Marcum 📖 @csmarcum.bsky.social · 22/09/2026
Maybe OMB is impounding more than NIH's budget. More from me in the Good Science Project newsletter by @stuartbuck.bsky.social : newsletter.goodscienceproject.org/p/policy-imp...
newsletter.goodscienceproject.org
Policy Impoundment
How OMB is using Regulatory Review to Slow NIH Policymaking
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Stuart Buck @stuartbuck.bsky.social · 22/09/2026
Just published this guest column about a huge White House vs. NIH battle that no one has yet publicly noticed: newsletter.goodscienceproject.org/p/policy-imp...
newsletter.goodscienceproject.org
Policy Impoundment
How OMB is using Regulatory Review to Slow NIH Policymaking
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Stuart Buck @stuartbuck.bsky.social · 28/05/2026
What I wrote there wasn't intended to denigrate scientists' hard work -- quite the opposite, my wish would be for them to have more freedom to propose their best ideas without holding back for fear of "not enough preliminary evidence" or "the study section isn't funding this type of thing right now"
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Stuart Buck @stuartbuck.bsky.social · 27/05/2026
All I meant was that NIH leaders and top scientists all admit to implicitly encouraging what I consider a type of dishonesty, i.e., write up a grant proposal as if the work will be done in the future but in fact much of it was already done in the past.
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Stuart Buck @stuartbuck.bsky.social · 27/05/2026
As for "dishonesty," the closest thing I can imagine might be this? goodscience.substack.com/p/do-we-fund...
goodscience.substack.com
Do We Fund New Research or Not?
A not-well-kept secret is that a great way to get funding from NIH is to stagger your applications such that you:
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Stuart Buck @stuartbuck.bsky.social · 27/05/2026
Larry Tabak used to say, "NIH's structure is so crazy only Congress could have come up with it."
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Stuart Buck @stuartbuck.bsky.social · 27/05/2026
Not sure what you mean by "the NIH encouraged dishonesty"? The structure of NIH -- Harold Varmus wrote in 2001 that it should be streamlined to 6 institutes, and Elias Zerhouni told me directly that he wanted more streamlining via the NIH Reform Act of 2006.
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Stuart Buck @stuartbuck.bsky.social · 27/05/2026
If you disagree with me, then you're saying that there shouldn't be any studies at all on behavior, personal and family dynamics, social influences, etc. Really?
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Stuart Buck @stuartbuck.bsky.social · 27/05/2026
Do you actually disagree with my conclusion that we shouldn't pull all of our dollars towards genetics and imaging?
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Stuart Buck @stuartbuck.bsky.social · 27/05/2026
Other long-term federal employees didn't respond to a complete straw-man.
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Stuart Buck @stuartbuck.bsky.social · 27/05/2026
You and the guy you're quoting seem to have no idea what I actually wrote!
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Stuart Buck @stuartbuck.bsky.social · 26/05/2026
What about this, or the many signatories, has anything to do with VC or libertarianism? goodscienceproject.org/a-good-scien...
goodscienceproject.org
A Statement of Principles re: Science Funding – Good Science Project
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Stuart Buck @stuartbuck.bsky.social · 26/05/2026
I do sincerely believe many things, but very little in your thread accurately represents anything that I said or that I believe
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Stuart Buck @stuartbuck.bsky.social · 26/05/2026
His claims about my motivations are completely wrong!
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Stuart Buck @stuartbuck.bsky.social · 26/05/2026
Sounds like you are directly in favor of the ad hominem fallacy rather than engaging with anything I actually wrote or have ever written (which isn't remotely "libertarian").
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Stuart Buck @stuartbuck.bsky.social · 26/05/2026
Here's what I think about science funding/policy. Do you doubt the motivations and knowledge of all the signatories? goodscienceproject.org/a-good-scien...
goodscienceproject.org
A Statement of Principles re: Science Funding – Good Science Project
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Stuart Buck @stuartbuck.bsky.social · 26/05/2026
Can you cite a few of these papers? I'd like to dig into them.
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Stuart Buck @stuartbuck.bsky.social · 26/05/2026
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Stuart Buck @stuartbuck.bsky.social · 26/05/2026
Yet another person with direct experience at NIH:
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Stuart Buck @stuartbuck.bsky.social · 26/05/2026
And here's someone who actually worked at NIMH at the time.
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Stuart Buck @stuartbuck.bsky.social · 26/05/2026
I agree with your point here! Not thinking NIMH should be dominated by neuroimaging and genetics doesn't remotely imply that we should get rid of basic science altogether. A number of folks who worked at NIH liked the piece:
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Stuart Buck @stuartbuck.bsky.social · 22/02/2026
That was by no means the main point of the piece, but always happy to correct minor mistakes.
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Stuart Buck @stuartbuck.bsky.social · 18/02/2026
Jeremy Berg makes the same critique, and I respond in this back-and-forth: substack.com/home/post/p-...
substack.com
A Reality-Based View of Government Funding of Science
Getting the diagnosis right before designing treatments
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Stuart Buck @stuartbuck.bsky.social · 14/02/2026
New at Good Science Project: goodscience.substack.com/p/venture-ca...
goodscience.substack.com
Venture Capital Has Lessons for Government and Philanthropy
tackling structural and bureaucratic rot
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Reposted by Stuart Buck
Yale ISPS @ispsyale.bsky.social · 06/02/2026
We were so thrilled to help host @stuartbuck.bsky.social for conversations with @meganranney.bsky.social of @yalesph.bsky.social and Michelle Hahn of the Tobin Center about the importance of reproducibility in science. bit.ly/4tnu7Dl
Megan Ranney and Stuart Buck sit in high-back leather chairs in a wood-paneled room
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Reposted by Stuart Buck
Dorothy Bishop @deevybee.bsky.social · 24/01/2026
@stuartbuck.bsky.social update on metascience in the budget goodscience.substack.com/p/update-on-... Emphasis on #replication should be good news, but my concern is it’ll be used for policy-based evidence creation. #NIH Study registration, strong methods & commiting to publish are key
goodscience.substack.com
Update on Metascience-Related Language in the NIH Budget
Earlier this week, the House and Senate appropriations committees released a bipartisan bill on NIH funding, along with a Joint Explanatory Statement that has a few paragraphs of metascience interest.
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Reposted by Stuart Buck
Matt Clancy @mattsclancy.bsky.social · 29/01/2026
It’s a debate between @jdworkin.bsky.social and @stuartbuck.bsky.social on the value of replicating research!
open.substack.com
Back and Forth on the Value of Replication
From Stuart:
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Reposted by Stuart Buck
Yale ISPS @ispsyale.bsky.social · 07/01/2026
Members of the Yale community: Please join us on Jan. 21 & 22 for two conversations with @stuartbuck.bsky.social on reproducibility in science. Register to attend on 1/21 at bit.ly/3Z5IZbu or on 1/22 at bit.ly/4qdXZAi
Stuart Buck headshot next to faded image of glowing lights and digits, with text: Reproducible Science is Good Science; Conversations with Sutart Buck of the Good Science Project; Jan. 21 & 22, 2026
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Stuart Buck @stuartbuck.bsky.social · 11/12/2025
An interview with me that came out today: fasterplease.substack.com/p/funding-ou...
fasterplease.substack.com
💰🧪 Funding outside the box: A Quick Q&A with … philanthropy expert Stuart Buck
'Breakthroughs are by definition a break with the status quo'
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Stuart Buck @stuartbuck.bsky.social · 23/11/2025
New post on NIH! goodscience.substack.com/p/a-top-scie...
goodscience.substack.com
A Top Scientist's Ideas as to NIH
An anonymous guest post
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Stuart Buck @stuartbuck.bsky.social · 29/10/2025
New post! goodscience.substack.com/p/ai-and-ped...
goodscience.substack.com
AI and Pediatric Cancer Research
The Trump Administration recently issued an executive order titled “Unlocking Cures for Pediatric Cancer with Artificial Intelligence,” with an accompanying announcement from the Department of Health ...
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Stuart Buck @stuartbuck.bsky.social · 20/10/2025
New post on the proposed compact with American universities: open.substack.com/pub/goodscie...
open.substack.com
A Compact Between Universities and Government?
Recently, the federal government released a proposed “Compact for Academic Excellence in Higher Education,” based on a proposal from investor Marc Rowan.
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Stuart Buck @stuartbuck.bsky.social · 15/10/2025
I know what your 3rd and 4th guesses were: Wordle 1,579 5/6 🟩⬜⬜⬜⬜ 🟩🟨⬜⬜⬜ 🟩🟩🟩🟩⬜ 🟩🟩🟩🟩⬜ 🟩🟩🟩🟩🟩
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Stuart Buck @stuartbuck.bsky.social · 27/09/2025
Was your third word drift?
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Reposted by Stuart Buck
Catharsis Theater: Relief for the Human Heart @catharsistheater.bsky.social · 22/08/2025
(1/5) Once, eccentric patrons funded wild dreams — radar in a mansion, secret codes in Shakespeare, scrolls from Vesuvius. Today, philanthropy feels safe and bureaucratic. What if wild giving could revive science, health and imagination? 🔗 www.palladiummag.com/2025/08/22/t... @stuartbuck.bsky.social
palladiummag.com
The Case for Crazy Philanthropy
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Stuart Buck @stuartbuck.bsky.social · 28/06/2025
Lucky: Wordle 1,469 2/6 ⬜⬜🟩⬜⬜ 🟩🟩🟩🟩🟩
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Stuart Buck @stuartbuck.bsky.social · 20/06/2025
Anyway, thanks for continuing to raise important issues!
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Stuart Buck @stuartbuck.bsky.social · 19/06/2025
I would never block you or Joe Bak-Coleman, because I am fine with (and even appreciate) being challenged. For me, blocking is only for people who are very disruptive or insulting. Not just because someone politely disagreed.
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Stuart Buck @stuartbuck.bsky.social · 19/06/2025
I basically agree, I guess, but I also think it's poor epistemics to block someone when the apparent reason is "they made an argument that I find inconvenient to answer." I hadn't said anything remotely disrespectful to him at that point. PS: you're definitely debating (disagreeing) with me! :)
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Stuart Buck @stuartbuck.bsky.social · 19/06/2025
you're debating right now! :) anyway, the only bad faith I see is the refusal to address an obvious counterpoint: are all people who work on a problem (reproducibility, anti-Semitism) to blame when a malignant politician weaponizes that issue? if not, why not?
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Stuart Buck @stuartbuck.bsky.social · 18/06/2025
When we funded Prasad, he was working on medical reversals and was writing stuff like this: www.statnews.com/2016/05/09/m... I can't control what someone does 8-10 years in the future.
statnews.com
Don’t believe what you read on new report of medical error deaths
Take the "news" that medical errors are the third leading cause of death with a grain of salt. Medical errors are poorly defined, and that estimate has been around for awhile.
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Stuart Buck @stuartbuck.bsky.social · 18/06/2025
Maybe we should have a Department of Government Efficiency: goodscience.substack.com/p/the-case-f...
goodscience.substack.com
The Case for a "Department of Government Efficiency"
There ought to be a federal department exclusively focused on making government work better, that is, government efficiency.
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Stuart Buck @stuartbuck.bsky.social · 18/06/2025
Carl Bergstrom blocked me for this post! Didn't know he was like that.
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Stuart Buck @stuartbuck.bsky.social · 15/06/2025
New guest post! goodscience.substack.com/p/nasa-is-wo...
goodscience.substack.com
NASA Is Worth Saving
Guest Column by Casey Handmer
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Stuart Buck @stuartbuck.bsky.social · 14/06/2025
*who's Thanks for the plug, I guess!
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Stuart Buck @stuartbuck.bsky.social · 13/06/2025
"so many"? I can think of arguably 2 people who might be what you're describing.
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Stuart Buck @stuartbuck.bsky.social · 13/06/2025
Good point. In fact, one might as well denounce anyone who has ever criticized anti-Semitism because they are somehow responsible for Trump weaponizing that idea against Columbia and Harvard.
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Reposted by Stuart Buck
Issues in Science and Technology @issuesinst.bsky.social · 10/06/2025
Showing which proposals do AND don’t receive federal funding can improve research and advance open science, @stuartbuck.bsky.social & @csmarcum.sciences.social.ap.brid.gy write. In fact, US funding agencies are required by law to provide much of this data already:
issues.org
Let Unfunded Grant Applications See the Light of Day
Showing which proposals do and don’t receive federal funding can improve research and advance open science.
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Stuart Buck @stuartbuck.bsky.social · 08/06/2025
And how does each red light have a different area in which other lights could occur? The size of stoplights isn't standard any more?
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Stuart Buck @stuartbuck.bsky.social · 08/06/2025
How do these red lights make any sense? No source of support, no reason to exist in the first place, no reason to have multiple red lights.
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