iiinova — where your digital self keeps evolving

Shashi Thutupalli @stpalli.bsky.social · 28/08/2026

(1/2) Mathematical Discourse (mathematicaldiscourse.org): in the words of Terence Tao is "a new online, peer-reviewed mathematics journal, publishing videos of mathematics research talks of the highest quality". Like this idea very much, hope the Sciences pick it up soon.

mathematicaldiscourse.org

Mathematical Discourse - Mathematical Discourse

A peer-reviewed video journal for mathematical research talks.

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Reposted by Shashi Thutupalli

Shashi Thutupalli @stpalli.bsky.social · 14/02/2026

With all the discussion about the 45mer, here is our story of what might precede that. And this story has a 42 — the atomic number of Molybdenum. If the origins of complex molecules, protocells and perhaps life, interest you, read our latest preprint — arxiv.org/abs/2601.11013

arxiv.org

De novo emergence of metabolically active protocells

A continuous route from a disordered soup of simple chemical feedstocks to a functional protocell -- a compartment that metabolizes, grows, and propagates -- remains elusive. Here, we show that a homo...

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Reposted by Shashi Thutupalli

Shashi Thutupalli @stpalli.bsky.social · 13/02/2026

Protocells from three inorganic salts, some formaldehyde and water? They grow? They synthesise organic molecules of core biomolecular classes: amino acids, sugars, lipid-like motifs? And, there are similar structures in today's oceans? Yes! Read on. arxiv.org/abs/2601.11013

arxiv.org

De novo emergence of metabolically active protocells

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Shashi Thutupalli @stpalli.bsky.social · 14/02/2026

arxiv.org

De novo emergence of metabolically active protocells

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Shashi Thutupalli @stpalli.bsky.social · 13/02/2026

arxiv.org

De novo emergence of metabolically active protocells

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Shashi Thutupalli @stpalli.bsky.social · 19/12/2025

Non-motile microbes are not prisoners of diffusive transport. Just their metabolic activity can be sufficient to stir up the ambient fluid and cause explosive long-range dispersal -- a "metabolic firework". Our latest work -- arxiv.org/abs/2512.16288

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Shashi Thutupalli @stpalli.bsky.social · 29/06/2025

We're looking for creative engineers/tinkerers/tool builders that want to engage with cutting-edge research questions in our lab at the @ncbsbangalore.bsky.social Please help me share the word!

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Shashi Thutupalli @stpalli.bsky.social · 26/06/2025

The Skysynth feature of from the Vera Rubin Observatory (@vrubinobs.bsky.social) is absolutely magical. Explore cosmic sounds. To get an idea, turn on your speakers for the movie below -- it's amazing! rubinobservatory.org/news/rubin-f...

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Shashi Thutupalli @stpalli.bsky.social · 24/06/2025

As always, Will is a master storyteller! Here’s a great thread about our recent paper.

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Shashi Thutupalli @stpalli.bsky.social · 21/06/2025

We have a new paper out on an issue that has been discussed for more than a century -- how can fundamental biophysical constraints on nutrient transport be overcome to solve one of the most significant challenges associated with the evolution of multicellularity? www.science.org/doi/10.1126/...

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Shashi Thutupalli @stpalli.bsky.social · 30/05/2025

We’re celebrating the newest graduate from my lab — Dr. Charuhansini Tvishamayi! Those of you in Bangalore, free next Sunday and interested, please come, it will be a pleasure! Poster courtesy: members of the lab.

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Shashi Thutupalli @stpalli.bsky.social · 09/05/2025

Such a cool finding, this! So great to see this since my group and I have discussed for years about how measuring the "energetic content" of cells using so called "bomb calorimetry" can be very misleading -- all gradient information is lost that way and clearly it is significant!

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Shashi Thutupalli @stpalli.bsky.social · 03/12/2024

We exposed yeast to -196 C freeze-thaw (without cryoprotectants) and interesting things happened -- the survival went up from about 1% to close to 80% in just 25 cycles! The preprint is out and feedback is highly welcome -- www.biorxiv.org/content/10.1...

biorxiv.org

Convergent cellular adaptation to a quiescence-like state in response to freeze-thaw stress

Rapid freeze-thaw is an extreme mechano-chemical perturbation that results in very low survival of many organisms (as low as a fraction of a percent). Here, using experimental evolution, we show that ...

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Reposted by Shashi Thutupalli

Mukund Thattai @thattai.bsky.social · 24/11/2024

I first visited KITP-UCSB as a grad student in 2003, and immediately fell in love with it. Here is the story of how my notebook from a 2010 KITP program I co-ran, on evolutionary cell biology, became the source of research questions that keep me busy to this day! www.kitp.ucsb.edu/sites/defaul...

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Shashi Thutupalli @stpalli.bsky.social · 22/11/2024

Before I start posting about newer results on this platform, here is a video from our most recent paper -- www.nature.com/articles/s41...

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