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Steven Florek

@stevenflorek.bsky.social
9 followers 10 following 45 posts

Neuromythographer

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Steven Florek @stevenflorek.bsky.social · 21/09/2026
entanglement = representation ?
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Steven Florek @stevenflorek.bsky.social · 13/09/2026
This evidence seems to contradict Lisa Feldman-Barrett's theory that facial expressions are cultural.
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Steven Florek @stevenflorek.bsky.social · 13/09/2026
The primate superior colliculus has two facial expression-reading populations: one for threat and another for fear. www.biorxiv.org/content/10.6...
biorxiv.org
Neuronal processing of facial expressions in the primate superior colliculus
Fast processing of emotionally salient facial expressions is widely believed to depend on a subcortical visual circuit from the superior colliculus through the thalamus to the amygdala, but the specif...
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Steven Florek @stevenflorek.bsky.social · 10/09/2026
Source pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Specification and survival of post-metamorphic branchiomeric neurons in the hindbrain of a non-vertebrate chordate
Tunicates are the sister group to the vertebrates, yet most species have a life cycle split between swimming larva and sedentary adult phases. During metamorphosis, larval neurons are largely replaced...
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Steven Florek @stevenflorek.bsky.social · 10/09/2026
Conserved architecture before evolutionary conjectures.
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Steven Florek @stevenflorek.bsky.social · 10/09/2026
Tunicates absorb their brains during larval to sessile adult metamorphosis. Neither forebrain nor interoceptive hindbrain survive. But the neck--the vertebrate-homologous r0 isthmus / r1 upper pons "coma center"--does survive. It will becomes the sensory-interoceptive-motor cerebral ganglion.
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Steven Florek @stevenflorek.bsky.social · 07/09/2026
The striatum, not the hippocampus, does sequence-based navigation in the neuroscience literature. But not in neuropsychology textbooks.
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Steven Florek @stevenflorek.bsky.social · 05/09/2026
The Zheng study was done in total darkness, which may have recruited the striatum for sequential turn-and-distance nav when there are few cues. "navigation" is neither fully distributed nor fully localized, to the chagrin of both systems and cogsci hedgehogs. pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Complementary Roles of the Hippocampus and the Dorsomedial Striatum during Spatial and Sequence-Based Navigation Behavior
We investigated the neural bases of navigation based on spatial or sequential egocentric representation during the completion of the starmaze, a complex goal-directed navigation task. In this maze, mi...
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Steven Florek @stevenflorek.bsky.social · 26/08/2026
the ego depletion phenomenon can cause psychologists to tire of theory
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Steven Florek @stevenflorek.bsky.social · 12/08/2026
Dopamine prediction errors are a popular paradigm. This paper finds that the caudate tail dopamine instead signals action-prediction errors. A better generalization may be triggering event causal structure reprocessing. www.biorxiv.org/content/10.6...
biorxiv.org
Modelling dopaminergic signals associated with habit formation through temporal-difference action learning
Action-selection is determined by a combination of goal-directed and habitual processes. Habits are defined as the reward-independent, stimulus-response relationships which form when an action is regu...
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Steven Florek @stevenflorek.bsky.social · 25/07/2026
The striatum has previously been shown to store procedural, turn-and-distance based navigation, and Pavlovian memories independent of the hippocampus. Memory is not a localized function; that does not mean brain parts--who never read William James' textbook--do not have their own repertoires.
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Steven Florek @stevenflorek.bsky.social · 16/07/2026
see also: functionspeak
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Steven Florek @stevenflorek.bsky.social · 09/07/2026
The Man Who Mistook His Wife for a Hat
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Steven Florek @stevenflorek.bsky.social · 11/06/2026
'Functional architecture' is a projection of questionable epistemic status. Those with perturbed consciousness may have insight into the true architecture of their minds unavailable to neurotypicals.
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Steven Florek @stevenflorek.bsky.social · 02/06/2026
When someone points out that the brain is a structured choanoflagellate colony, and the developmental ghost of an ancestral hemichordate body plan ... Everybody demands that they revert to computer, electrical, math, psychology, or philosophical words.
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Steven Florek @stevenflorek.bsky.social · 01/06/2026
Whenever I forget what a nomological network is, I rewatch the witch construct operationalization scene from Monty Python and the Holy Grail
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Steven Florek @stevenflorek.bsky.social · 21/05/2026
The jagged nature of generative AI intelligence drops a hammer on the generalized g-IQ construct yet it is getting better at most everything
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Steven Florek @stevenflorek.bsky.social · 16/05/2026
Encapsulated has joined the 4E chat
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Steven Florek @stevenflorek.bsky.social · 12/05/2026
If you're incredulous about average NAc activations forecasting mass appeal better than individual choice, there are many other paradigms in the literature to scoff at, e.g. journals.sagepub.com/doi/10.1177/...
academic.oup.com
Neuroforecasting reveals generalizable components of choice
Abstract. Accurate forecasts of population-level behavior critically inform institutional choices and public policy. While neuroforecasting research sugges
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Steven Florek @stevenflorek.bsky.social · 11/05/2026
the primary function of the brain is generating exegesis that isn't even wrong, to minimize prediction error
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Steven Florek @stevenflorek.bsky.social · 23/04/2026
Respectfully, the hopes for a Kuhnian revolution may be dashed by a Hegelian synthesis bsky.app/profile/gord...
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Steven Florek @stevenflorek.bsky.social · 09/01/2026
Basolateral amygdala threat anxiety lies in the astrocytes, not the neurons 😮https://www.biorxiv.org/content/10.64898/2026.01.07.697973v1
biorxiv.org
Astrocytic Encoding of Threat in the Basolateral Amygdala
The basolateral amygdala (BLA) has long been implicated in threat detection and the generation of anxiety states. While previous experiments have demonstrated the important role of BLA principal neuro...
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Steven Florek @stevenflorek.bsky.social · 02/01/2026
Psychology constructs are real, brain areas are a bunch of epiphenominal degenerates
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Steven Florek @stevenflorek.bsky.social · 12/12/2025
not even eukaryotes pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Habits of Highly Effective Biofilms: Ion Signaling
How do neighboring bacterial biofilms sense and communicate with each other? In a recent paper, Liu et al. (2017) demonstrate how electrical signaling allows communication of metabolic states between adjacent B. subtilis biofilms, providing a ...
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Steven Florek @stevenflorek.bsky.social · 25/11/2025
Ephaptic coupling inhibition implements Drosophila sweetness taste neuron dominance www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Steven Florek @stevenflorek.bsky.social · 24/11/2025
Insect brains do beta feature attention too pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Oscillations in the central brain of Drosophila are phase locked to attended visual features
There is increasing evidence that even the smallest animal brains provide a capacity for selective attention and subjective awareness, but it is unknown if similar mechanisms might be employed as in higher animals. Recent work in insects highlights ...
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Steven Florek @stevenflorek.bsky.social · 23/11/2025
Those single-neuron control studies involve a controlled sensory feedback loop (vision, touch, etc). I don't think single-neuron ghrelin feedback control is very feasible.
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Steven Florek @stevenflorek.bsky.social · 19/11/2025
Possibly www.frontiersin.org/journals/mol...
frontiersin.org
Frontiers | From molecule to oblivion: dedicated brain circuitry underlies anesthetic loss of consciousness permitting pain-free surgery
The canonical view of how general anesthetics induce loss-of-consciousness (LOC) permitting pain-free surgery posits that anesthetic molecules, distributed t...
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Steven Florek @stevenflorek.bsky.social · 20/09/2025
If I can't parse it, then it's not parsimonious
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Steven Florek @stevenflorek.bsky.social · 13/08/2025
Bioethicists determine we are morally obligated to infest humanity with ticks that repress meat-eating @neuroskeptic.bsky.social onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Beneficial Bloodsucking
The bite of the lone star tick spreads alpha-gal syndrome (AGS), a condition whose only effect is the creation of a severe but nonfatal red meat allergy. Public health departments warn against lone s...
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Steven Florek @stevenflorek.bsky.social · 12/06/2025
The right paracingulate sulcus would be a prime suspect pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
A Specific Brain Structural Basis for Individual Differences in Reality Monitoring
Much recent interest has centered on understanding the relationship between brain structure variability and individual differences in cognition, but there has been little progress in identifying speci...
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Steven Florek @stevenflorek.bsky.social · 11/06/2025
I mangled the conclusion: millisecond predator vulnerability is a small price to pay for bilateral blinking.
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Steven Florek @stevenflorek.bsky.social · 11/06/2025
Blink once if you are the VTA, three times if you are p32pr. So why do both eyes blink at once? Probably because with single-eye blinking, the eyeblink signal can no longer be interpreted as an episode boundary. A small price to pay for millisecond predator vulnerability. @markolas.bsky.social
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Steven Florek @stevenflorek.bsky.social · 11/06/2025
Another conjecture I will add: there exists a cingulate eye field (CEF) inside the area of midcingulate cortex associated with cognitive dissonance (p32pr in HCP). We all recognize eye flutter as confusion.
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Steven Florek @stevenflorek.bsky.social · 11/06/2025
Another function of blinking seems to be to reset the retina to adjust to visual conditions, such as luminosity or blur. We have all unconsciously performed blinking to correct blurry vision. www.pnas.org/doi/10.1073/...
pnas.org
Eye blinks as a visual processing stage | PNAS
Humans blink their eyes frequently during normal viewing, more often than it seems necessary for keeping the cornea well lubricated. Since the clos...
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Steven Florek @stevenflorek.bsky.social · 11/06/2025
Eyeblinks also momentarily disengage the dorsal attention network and activate the default mode network. This might be like 'autosave' for episodic memory. www.pnas.org/doi/full/10....
pnas.org
Blink-related momentary activation of the default mode network while viewing videos | PNAS
It remains unknown why we generate spontaneous eyeblinks every few seconds, more often than necessary for ocular lubrication. Because eyeblinks ten...
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Steven Florek @stevenflorek.bsky.social · 11/06/2025
A recent finding is that blinking correlates with VTA activation, the brain's central dopamine center. This may serve a kind of timestamping function in episodic memory. If the eyes are the window into the soul, blinking may be a window into the VTA. pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Dopaminergic processes predict temporal distortions in event memory
Our memories do not simply keep time — they warp it, bending the past to fit the structure of our experiences. For example, people tend to remember items as occurring farther apart in time if they spa...
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Steven Florek @stevenflorek.bsky.social · 11/06/2025
As early as 1945, it was observed that blinking during reading seemed to correspond to gaps in words on the page. We also blink on unfamiliar words. www.newscientist.com/article/2461...
newscientist.com
Blinking may give your brain a micro break during cognitive tasks
When reading a book, we tend to blink over less familiar words, which suggests it may have a cognitive role
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Steven Florek @stevenflorek.bsky.social · 11/06/2025
Why do we blink with both eyes? One reason seems to be blinking's role in chunking of episodic memory boundaries. 🧵
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Steven Florek @stevenflorek.bsky.social · 26/04/2025
Love the sparkplug metaphor for the weak language used for roles and telos
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Steven Florek @stevenflorek.bsky.social · 26/02/2025
Platt seems downright suspicious of theory here
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Steven Florek @stevenflorek.bsky.social · 26/02/2025
I think it is important to distinguish 1. theory - 'the dopamine theory of schizophrenia' 2. iteratively testing hypothesis spaces - 'antagonizing D2 should alleviate sch symptoms' 3. insight into hyp spaces - 'what if that's all downstream of NMDAR loss?' Platt called for 2-3; 1-2 not so much.
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Steven Florek @stevenflorek.bsky.social · 23/01/2025
The Big Five is just a lexical aggregation of *English personality adjectives* used in test questions. That is why it is circular, and language-dependent. Four dimensions are just continuous versions of MBTI dims; Jung mapped neuroticism to "Shadow". McCrae & Acosta discussed this ~1990 IIRC.
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Steven Florek @stevenflorek.bsky.social · 12/01/2025
I don't think hypothesis-driven neuroscience, nor the psych repl crisis, can be rescued by choosing btw "all swans are white", "swanness causes whiteness", or "if no swanness, then there would be no whiteness"
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Steven Florek @stevenflorek.bsky.social · 11/01/2025
That aspirin reduces headache is a reliable large effect observation. The causal theory of why aspirin does so is provisional, and subject to ceteris paribus caveats about unknown mediators awaiting discovery. cornellsun.com/2015/10/20/b...
cornellsun.com
Boyce Thompson Researchers Discover Aspirin Works Differently Than Thought
Researchers at the University’s Boyce Thompson Institute have recently uncovered that aspirin might not be working the way most doctors think it does. Prof. Daniel Klessig, plant science at BTI, has b...
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