Reposted by Stephanie LoLeonie Lorenz @leonielorenz.bsky.social · 09/09/2026I am excited to share that my main PhD work on developing a Wright-Fisher model for replacement dynamics in Streptococcus pneumoniae populations following vaccine introductions has been published in Genome Medicine! We used it to investigate optimal surveillance strategies. rdcu.be/UGjFZJBhKVba 173
Stephanie Lo @stephlo.bsky.social · 02/12/2025[🚨Data release🚨] The #GPS_project database Monocle is now having 40k pneumococcal genomes and detailed metadata ! Thanks @HarryHung at @sangerinstitute and Simran Utreja at CDC to put them together! data-viewer.monocle.sanger.ac.uk/project/gps 020
Stephanie Lo @stephlo.bsky.social · 08/11/2025[🚨New Paper 🚨]SeroBA recognised 102/107 known pneumococcal serotypes and its companion resources webpage SeroBAnk are now published on Microbial Genomics @microbiologysociety.org www.microbiologyresearch.org/content/jour...microbiologyresearch.orgSeroBA(v2.0) and SeroBAnk: a robust genome-based serotyping scheme and comprehensive atlas of capsular diversity in Streptococcus pneumoniaeThe unprecedented number of Streptococcus pneumoniae (the pneumococcus) genomes sequenced in recent years has accelerated the discovery of novel serotypes and highlighted the genetic diversity both be... 020
Reposted by Stephanie LoGlobal Pneumococcal Sequencing Project @globalpneumoseq.bsky.social · 24/09/2025🦠🧪🧬 Excited to share that our GPS Pipeline, the portable and scalable genomic pipeline for Streptococcus pneumoniae surveillance, is now published in @natcomms.nature.com 🔗 nature.com/articles/s41... #GPS_projectnature.comGPS Pipeline: portable, scalable genomic pipeline for Streptococcus pneumoniae surveillance from Global Pneumococcal Sequencing Project - Nature CommunicationsThe GPS Pipeline enables accessible and scalable genomic surveillance of Streptococcus pneumoniae. It performs quality control and in silico typing of sequencing reads with high accuracy using a single simple command, without requiring the internet. 233
Reposted by Stephanie LoAlannah King @dralannah.bsky.social · 23/09/2025It's likely the next pandemic will come from wildlife. But how can we prepare for the next spillover event, if we don't understand the diversity of viruses out there? 🦔🦠 Check out our Genomewatch article, where we discuss using meta-genomics to study viral diversity in wild mammals 🖥️🧬 rdcu.be/eHIBlurldefense.proofpoint.comZoonotic threats hidden in wildlifeNature Reviews Microbiology - This Genome Watch article explores how metagenomics can be used to investigate viral diversity and track emerging zoonotic disease threats from wildlife. 052
Reposted by Stephanie LoGlobal Pneumococcal Sequencing Project @globalpneumoseq.bsky.social · 22/09/2025[New pre-print🚨] When a single genotype (pbp) confer resistance (penicillin, amoxicillin, cephalosporins) to multiple antibiotics, how do we make sense of genetic changes and their impact on AMR? A new concept - AMR cartography is invented. www.biorxiv.org/content/10.1...biorxiv.org 153
Reposted by Stephanie LoGlobal Pneumococcal Sequencing Project @globalpneumoseq.bsky.social · 18/09/2025[🚨 New paper] The first nationwide, longitudinal WGS analysis of Streptococcus pneumoniae in Taiwan (2006–2022). 1,343 isolates from 27 hospitals, we track serotype, AMR, and genomic lineage before and after PCV13. #GPS_project #PCV13_impact #Taiwan www.microbiologyresearch.org/content/jour...microbiologyresearch.orgGenomic analysis of the Streptococcus pneumoniae in Taiwan: a nationwide study from 2006 to 2022Streptococcus pneumoniae remains a leading respiratory pathogen for children and the elderly. In Taiwan, a national PCV13 catch-up vaccination programme for children began in March 2013. This study in... 153
Stephanie Lo @stephlo.bsky.social · 03/09/2025[New paper alert 🚨 ] What happens when pneumococci 'slip' and 'add' just one extra A in a promoter spacer of a sugar scavenging gene? 🧬 www.cell.com/cell-host-mi...cell.comNaturally acquired promoter variation influences Streptococcus pneumoniae infection outcomesBarton et al. identify Streptococcus pneumoniae promoters containing repetitive nucleotide sequences that promote DNA strand slippage and accumulation of promoter sequence mutations. This drives popul... 194
Stephanie Lo @stephlo.bsky.social · 06/07/2025Our team is hiring an ambitious senior bioinformatician to look into bacterial capsules . This position will closely collaborate with EMBL-EBI Stephen Bentley, John Lees, Steph Lo Closing date: 20 July 2025 sanger.wd103.myworkdayjobs.com/en-GB/Wellco...sanger.wd103.myworkdayjobs.comBioinformatician – Bacterial GenomicsDo you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge... 000
Stephanie Lo @stephlo.bsky.social · 04/06/2025It’s my great pleasure to present the Global Pneumoocccal Sequencing project at #LISSSD25 I feel humbled to learn more about Group A and Group B streptococci and other species, and meet great minds to discuss science. #GPS_project 050
Stephanie Lo @stephlo.bsky.social · 04/06/2025Dr Dorota Jamrozy presents a well-powered GWAS to identify genetic features associated with invasive #GBS disease as compared with carriage at #LISSSD25 Thanks to the >20,000 GBS genomes in the #JUNO_project funded by @gatesfoundation.bsky.social 040
Reposted by Stephanie LoGlobal Pneumococcal Sequencing Project @globalpneumoseq.bsky.social · 03/06/2025Each year, over half a million of pneumococcal disease in children were reported in China Our paper showed 1) 94.3% serotypes covered by PCV13 2) 99.8% isolates resistant to ≥1 antibiotics Routine PCV in children will ↘️ pneumococcal disease and AMR! www.microbiologyresearch.org/content/jour...microbiologyresearch.orgGenomic analysis of invasive and non-invasive disease-causing Streptococcus pneumoniae isolated from children between 2014 and 2023 in Suzhou, ChinaIn 2017, 553,000 clinical cases of Streptococcus pneumoniae in children were reported in China, although the pneumococcal conjugate vaccine (PCV), which targets the pneumococcal capsule, is not includ... 111
Stephanie Lo @stephlo.bsky.social · 02/06/2025@sophiebelman.bsky.social carried out this spatiotemporal analysis to quantify how fast a pneumococcal lineage can travel across the country, and this work was published on pmc.ncbi.nlm.nih.gov/articles/PMC... #LISSSD25pmc.ncbi.nlm.nih.govEmergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing studySerotype 24F is one of the emerging pneumococcal serotypes after the introduction of pneumococcal conjugate vaccine (PCV). We aimed to identify lineages driving the increase of serotype 24F in France ... 010
Reposted by Stephanie LoStuart Campbell @sc345.bsky.social · 02/06/2025@stephlo.bsky.social & global partners describe the extent (worldwide) of intra-country spread (<4 years) of pneumococcus through in silico genotyping, then outlines genotypic methods of predicting vaccine escape (capsules 33F -> 33E) using this in silico data. #LISSSD25 #idsky 154
Stephanie Lo @stephlo.bsky.social · 31/05/2025Good morning Brisbane! What a nice view to prepare my very first talk at #LISSSD25 ! Looking forward to meeting people at the conference. #GPS_project #pneumococci #Genomics 040
Reposted by Stephanie LoMicrobiology Society @microbiologysociety.org · 17/05/2025Society Event Grant – applications for funding to attend EC Summer Conference 2025 are now open until 24 May at 23:59 BST. Check your eligibility and apply now- microb.io/3S9T6cOmicrob.ioSociety Events GrantFunds are available to support eligible members attending the Society Annual Conference or one other Society meeting per year. 112
Stephanie Lo @stephlo.bsky.social · 07/05/2025The SeroBA(v2.0) is now available in the GPS pipeline github.com/GlobalPneumo... #GPS_project #pneumococci #serotype #bioinformaticsgithub.comGitHub - GlobalPneumoSeq/gps-pipeline: Nextflow Pipeline for processing Streptococcus pneumoniae sequencing raw reads (FASTQ files) by the GPS Project (Global Pneumococcal Sequencing Project)Nextflow Pipeline for processing Streptococcus pneumoniae sequencing raw reads (FASTQ files) by the GPS Project (Global Pneumococcal Sequencing Project) - GlobalPneumoSeq/gps-pipeline 020
Reposted by Stephanie LoGlobal Pneumococcal Sequencing Project @globalpneumoseq.bsky.social · 01/05/2025Keeping track on the number of hashtag#pneumococcal serotypes? SeroBAnk is an atlas of pneumococcal capsule to display its genetics, biochemical structure and serological profiles www.pneumogen.net/gps/#/serobankpneumogen.netGPS :: Global Pneumococcal Sequencing ProjectHomepage of The Global Pneumococcal Sequencing Project 121
Reposted by Stephanie LoGlobal Pneumococcal Sequencing Project @globalpneumoseq.bsky.social · 01/05/2025Do you need a #bioinformatic tool to detect almost all serotypes in #pneumococci? The new SeroBA v2.0 can detect 102 of 107 known pneumococcal serotypes www.biorxiv.org/content/10.1...biorxiv.orgSeroBA(v2.0) and SeroBAnk: a robust genome-based serotyping scheme and comprehensive atlas of capsular diversity in Streptococcus pneumoniaeThe unprecedented number of Streptococcus pneumoniae (the pneumococcus) genomes sequenced in recent years has accelerated the discovery of novel serotypes and highlighted the genetic diversity both be... 155
Reposted by Stephanie LoJosie Bryant @josiebryant.bsky.social · 01/05/2025Happy to share the first preprint from my lab. Great work by Lewis Fisher and collaboration with Jukka Corander www.biorxiv.org/content/10.1...biorxiv.orgHigh frequency body site translocation of nosocomial Pseudomonas aeruginosaPseudomonas aeruginosa is an important nosocomial pathogen which can cause serious infections across diverse anatomic locations. Infections can spread within an individual to different body sites, but... 12317
Reposted by Stephanie LoThe Lancet @thelancet.com · 01/05/2025🆕 Rates of AMR up to 3 times greater in outpatients with cancer compared to those without cancer, suggests USA data. Find out more in @thelancetoncol.bsky.social: tinyurl.com/2uy9ttvv 32518
Stephanie Lo @stephlo.bsky.social · 01/05/2025Do you need a #bioinformatic tool to detect almost all serotypes in #penumococci ? The new SeroBA v2.0 can detect 102 of 107 pneumococcal serotypes github.com/GlobalPneumo...github.comIssues · GlobalPneumoSeq/serobaA Fork of the Original SeroBA. Contribute to GlobalPneumoSeq/seroba development by creating an account on GitHub. 100
Reposted by Stephanie LoGlobal Pneumococcal Sequencing Project @globalpneumoseq.bsky.social · 24/03/2025As part of the #GPS_project, @Abel_AberaN led us to understand the circulating #pneumococcal lineages (carriage and disease)!in Ethiopia after #PCV10 www.microbiologyresearch.org/content/jour...microbiologyresearch.orgGenomic characterization of Streptococcus pneumoniae isolates obtained from carriage and disease among paediatric patients in Addis Ababa, EthiopiaBackground and aims. Despite the introduction of pneumococcal conjugate vaccines (PCVs), Streptococcus pneumoniae still remains an important cause of morbidity and mortality, especially among children... 111
Stephanie Lo @stephlo.bsky.social · 17/02/2025An up-to-date review on the evolving landscape of pneumococcal capsule - seroepidemiology -recently recognised novel serotypes -mitis expressed pneumo capsule -future research direction #pneumococcus #vaccine #PCV #NahmLab led by @FerozeGanaie pubmed.ncbi.nlm.nih.gov/39878373/pubmed.ncbi.nlm.nih.govUpdate on the evolving landscape of pneumococcal capsule types: new discoveries and way forward - PubMedSUMMARY<i>Streptococcus pneumoniae</i> (the "pneumococcus") is a significant human pathogen. The key determinant of pneumococcal fitness and virulence is its ability to produce a protective polysaccha... 051
Reposted by Stephanie LoKate Baker @ksbakes.bsky.social · 29/11/2024There are four (that's right four!) academic posts open at the School of Biological sciences at Cambridge University. Check them out here: www.jobs.cam.ac.uk/job/?categor... Gr10/11 (AssocProf/Reader; now Prof) Closing 26/1/25. Looking for excellent, collaborative people. Spread the word!jobs.cam.ac.ukJob Opportunities - University of CambridgeCurrent Academic jobs at the University of Cambridge. 0128
Reposted by Stephanie LobioRxivpreprint @biorxivpreprint.bsky.social · 30/11/2024A Portable and Scalable Genomic Analysis Pipeline for Streptococcus pneumoniae Surveillance: GPS Pipeline www.biorxiv.org/content/10.1101/202… biorxiv.orgA Portable and Scalable Genomic Analysis Pipeline for Streptococcus pneumoniae Surveillance: GPS Pipeline https://www.biorxiv.org/content/10.1101/2024.11.27.625679v1 Ever increasing global sequencing capacity provides an unprecedented opportunity in utilising genomi 022