What is the optimal diagnostic strategy for rheumatoid arthritis-associated interstitial lung disease? This review assesses the reliability, validity, and clinical utility of the currently available…

NIT-based strategies that accurately identify ‘at-risk’ MASH are needed to guide patient selection for drug therapy and assess treatment response. Explore available NITs and emerging ones that…

Nirsevimab is highly effective in preventing severe respiratory syncytial virus disease requiring emergency department visits, hospitalization, or intensive care unit admission.

Venous air embolism is a rare iatrogenic complication of contract-enhanced radiological procedures, with a diverse range of presentations. This patient's sudden-onset of dyspnea and dizziness…

A phase 1 study has shown initial evidence that A-319, a bispecific T-cell engager, is well tolerated by patients with systemic lupus erythematosus and efficacious.

A man presenting with bilateral epididymo-orchitis and high fever was diagnosed with polyarteritis nodosa after 18F-FDG PET/CT revealed the characteristic “ant-farm-like” pattern previously observed…

Using optical coherence tomography angiography to measure vessel density may detect glaucoma progression earlier than using OCT to determine structural circumpapillary retinal nerve fiber layer…

Surveillance data for invasive meningococcal disease (IMD) in the USA has revealed shifting serogroup dominance, outbreaks extending beyond traditional settings, and increasing incidence among…

A man with type 2 diabetes, obesity, and signs and symptoms of diabetic peripheral neuropathy was started on semaglutide. After 6 months, repeat in vivo corneal confocal microscopy showed improvement…

Primary resistance to nirsevimab has rarely been reported in the context of its recent implementation. The detection of a nirsevimab-resistant RSV-B strain in a monoclonal antibody-naïve patient…

Treatment with the novel antibody–drug conjugate tambotatug pelitecan significantly prolongs the survival of patients with small-cell lung cancer that has progressed after first-line therapy.

A review of the longterm cardiovascular sequalae of SARS-CoV-2 infection in children, focusing on multisystem inflammatory syndrome in children, subclinical myocardial dysfunction, dysautonomia, and…

SGLT2 inhibitors are increasingly being investigated as a way of delaying progression from prediabetes to type 2 diabetes. Understand the current evidence in adults and the arguments for and against…

The May 2026 Andes virus outbreak was notable for its occurrence aboard an international cruise ship and evidence of human-to-human transmission, a rare feature among hantaviruses. Find out the key…

People with invasive cancer have a significantly higher risk for stroke than the general population, particularly in the initial 3 months after diagnosis and those with pancreatic or lung cancer.

Update on the pathophysiology, clinical presentation, diagnostic approach, and neuroimaging features for infiltrative and inflammatory disorders involving the pituitary gland, with strategies to aid…

An international panel of experts has proposed a framework for the use of resmetirom and semaglutide in the treatment of patients with MASH and significant fibrosis but no cirrhosis.

Anorectal melanoma is often diagnosed at an advanced stage because symptoms such as rectal bleeding can mimic benign conditions. In this case, prompt colonoscopy ensured a positive outcome.

Does AI have potential as a clinical collaborator for the interpretation of esophageal manometry data, and what are the practical requirements that must be met for responsible clinical implementation?

The risk for ketoacidosis varies by patient characteristics among people with type 2 diabetes using SGLT2 inhibitors and is apparent throughout treatment.

International consensus report providing guidance on the principles and practice of implementing general population screening for islet autoantibodies to detect and diagnose early-stage type 1…

This case charts an unusual destructive course from endotheliitis-like presentation, through negative scraping-based microbiological tests, to severe corneal melting with sloughed necrotic tissue…

Telemedicine offers demonstrable benefits in cancer care, such as access, continuity, and patient satisfaction. Yet its integration has been uneven, its governance remains fragmented, and its…

The ACASA-TAVI and NOTION-4 trials have provided conflicting results with regard to the use of direct oral anticoagulants after transcatheter aortic valve implantation for severe aortic valve…

An overview of the biological characteristics and clinical behavior of the four major molecular subtypes of endometrial cancer, as well as the therapeutic implications. Discover the optimal therapies…

A practical framework for choosing air, gas, silicone oil, and heavier agents by linking tamponade behavior with retinal geography, disease complexity, and postoperative feasibility.

A highly myopic patient developed rapidly progressive capsular contraction syndrome after cataract surgery in one eye, together with spontaneous crystalline lens dislocation in the fellow unoperated…

While the cardiovascular-kidney-metabolic syndrome framework recognizes MASLD as a major manifestation, it does not incorporate hepatic staging into risk stratification. A proposed extension of the…

Visuospatial disturbances often dominate early PCA, leading to misdiagnosis as ocular, psychiatric, or nonspecific cognitive disorders. This case highlights assessing higher-order visual function…

Influenza-associated myocarditis can present with a broad range of manifestations, from mild chest discomfort to fulminant cardiogenic shock. This case series underscores the need for maintaining a…

Acute stroke remains the only major time-dependent vascular emergency without a validated blood biomarker in routine practice. Which candidates are closest to clinical implementation?

Post-exertional malaise may reflect multisystem physiological dysregulation instead of resulting from exertion in ME/CFS and long COVID. Could longitudinal cardiometabolic profiling be key to…

Infants hospitalized with pertussis have more severe outcomes with azithromycin than with clarithromycin.

Latest evidence supports a shift from a uniform low-dose approach towards more individualized atropine prescribing based on age, ethnicity, and progression risk.

Delve into the evidence for coronary microvascular dysfunction and subclinical myocardial involvement in GPA. Could an immunocardiology framework for individualized cardiovascular assessment be…

This rare case suggests sympathetic ophthalmia can worsen proliferative diabetic retinopathy. How would you balance immunomodulation and glycemic control to preserve vision in this pregnant patient?

Tuberculosis preventive treatment significantly reduces tuberculosis incidence and all-cause mortality in people with HIV initiating antiretroviral therapy.

Receiving glucocorticoids for early rheumatoid arthritis by intra-articular or intramuscular injection rather than orally could halve patients’ risk for persistent use at 1 year.

Discover a stratified, scenario-adaptive, technical implementation framework for the screening, diagnosis, and detection of norovirus at the community, clinical, and environmental levels,…

A rare clinical scenario involving ankylosing spondylitis diagnosed in a woman with a history of successfully treated osteoarticular brucellosis. Is it a causal association or separate pathology?

Daily treatment with oral gildeuretinol acetate significantly reduces the growth rate of retinal atrophic lesions, relative to placebo, in adolescents and adults with Stargardt disease.

The relationship between rheumatoid arthritis and reproductive health is multifaceted. Familiarize yourself with the current evidence on fertility, birth outcomes, and other sexual and reproductive…

High exhaled carbon monoxide levels may be associated with a significantly decreased risk for Parkinson disease in people who have never smoked, without increasing the risk for smoking-related…

From onset to diagnosis, the patient journey for men and women with angina differs greatly. Through two patient perspectives, a physician highlights the diagnostic challenges, sex differences in…

B-cell reconstitution usually begins within months of stopping anti-CD20 therapy, but this patient remained depleted more than 5 years later, underscoring the need for long-term immunological…