Sign in

Boris Sobolev

@sobor.bsky.social
596 followers 56 following 75 posts

Causal questions, counterfactual answers

PostsRepliesMedia
Boris Sobolev @sobor.bsky.social · 25/01/2025
@pwgtennant.bsky.social Peter, your repost should bring us who study SES in health to re-evaluation of how we do research. We should focus on causal questions, causal methodology, DAGs, probability of benefit, recovery from selection bias, transportability of effects, causal fairness.
021
Boris Sobolev @sobor.bsky.social · 18/01/2025
ATE? nah… We ask how many patients would get better with treatment but not without it. youtu.be/ms4z2i7JzVY
youtu.be
Probability of benefit in clinical practice
YouTube video by SobolevSpaces
010
Boris Sobolev @sobor.bsky.social · 24/12/2024
sometimes, a flower is just a flower
010
Boris Sobolev @sobor.bsky.social · 23/12/2024
Un laberinto de tentaciones
000
Boris Sobolev @sobor.bsky.social · 21/12/2024
If you've never tasted the dishes prepared by la chefa Anayeli Suazo of Tentaciones, you don't know what a gourmet meal is and what it looks like.
000
Boris Sobolev @sobor.bsky.social · 20/12/2024
Nothing can beat sleeping until noon on vacation
010
Boris Sobolev @sobor.bsky.social · 14/12/2024
I had a quick chat with Elias Bareinboim on the way from the a/p #neurISP24… He reminds me of Mozart, who barely has time to write down all the revelations of causality pouring on him from above. 😊
020
Boris Sobolev @sobor.bsky.social · 23/11/2024
Wondering about #causal mediation analysis in comparative effectiveness research? Check out our framework for the mediating effect of treatment time of 2 treatment methods for complex coronary artery disease. doi.org/10.9778/cmaj...
010
Boris Sobolev @sobor.bsky.social · 20/11/2024
There’s this misconception that 'causality is in the design.' Apart from being uninformed, this assertion is fed by a bigger fallacy: that causality is a product of our mind rather than a feature of the material world. Pearl’s major contribution is grounding causality in materialism.
032
Boris Sobolev @sobor.bsky.social · 20/11/2024
Oh, I agree that causal claims come from reasoning, and that design is a part of it. I just don't see how reasoning using words can be superior to reasoning using mathematical notation. Pearl’s formulas easily describe RCT. But trialsts have a hard time to describe the estimand of their experiment.
010
Boris Sobolev @sobor.bsky.social · 20/11/2024
So, you admit that your notation doesn’t capture the difference btw association and causation? And! and your reasoning ‘it’s in the design’ is not reflected in your notation, right?
100
Boris Sobolev @sobor.bsky.social · 20/11/2024
I’m glad that you are using a rigorous notation for statistical hypothesis testing. Because it offers me an opportunity to ask, where is causality here?
210
Boris Sobolev @sobor.bsky.social · 20/11/2024
Notation gives us a means to express our ideas in rigorous and transparent fashion. Whether it is for radius and circumference, or for a value that outcome variable would assume in unit u, if it were assigned to a treatment group regardless of any factors that might influence treatment assignment.
121
Boris Sobolev @sobor.bsky.social · 20/11/2024
You mean, this Fisher? 👇🏻 A denier of causal relationship btw tobacco smoking and lung cancer? yet ‘seeing’ causality btw race and the quality of ‘human stock’? Btw ‘high intellectual calibre’ of parents and their offsprings? Inverse link btw ‘fertility’ and ‘achievement’ of most valuable classes?
020
Boris Sobolev @sobor.bsky.social · 19/11/2024
The most amazing part of the EBM proselytism is that it cannot specify the estimand of an RCT. The Pyramid evangelists keep repeating with religious fervor that the causal effect is in the design, but they refuse to reveal what the causal effect is. Credo quia absurdum
120
Boris Sobolev @sobor.bsky.social · 19/11/2024
There’s this misconception that causal evidence comes from data. It comes from reasoning. Unless, of course, the High Priests of EBM Pyramid deny us mere mortals the ability to think.
140
Boris Sobolev @sobor.bsky.social · 19/11/2024
020
Boris Sobolev @sobor.bsky.social · 19/11/2024
I’ve always been puzzled by my aversion to interpreting RCT outputs as evidence. Finally, I figured it out. An RCT’s output, vaunted as assumption-free, are in fact not falsifiable. There is nothing to falsify. That what makes EBM Priests so pompous: they present infallible evidence.😂
030
Boris Sobolev @sobor.bsky.social · 19/11/2024
010
Boris Sobolev @sobor.bsky.social · 19/11/2024
I agree. The PO notation is not needed to understand the counterfactual nature of the question that a randomized experiment purports to address. The notation of Pearl’s First Principle would suffice.
130
Boris Sobolev @sobor.bsky.social · 19/11/2024
When I hear 'I don't like Pearl's causal hierarchy', it reminds me of an old story. A tourist at the Louvre looks at La Gioconda and declares: 'I don't like it!' The curator nearby responds: 'Oh, she's seen so many people over the centuries that nowadays she decides who gets to like her.'
120
Boris Sobolev @sobor.bsky.social · 19/11/2024
The evangelists of EBM gospel fail to realize that the ATE in randomized trials not only involves counterfactuals, but actually answers a counterfactual question.👇🏻
140
Boris Sobolev @sobor.bsky.social · 18/11/2024
There’s this misconception that probability of diverging outcomes of alternative treatments is just a theoretical consideration Here’s the probability of benefit (survival if treated early, mortality if not) estimated empirically. Each bar shows the range of its possible values.
020
Boris Sobolev @sobor.bsky.social · 18/11/2024
The types of questions we ask determine the types of answers we get. 👇🏻
040
Boris Sobolev @sobor.bsky.social · 18/11/2024
Amazing! Pearl’s probability of causation coincides with the causal effect P(Y_x) - P(Y_x′) under some conditions. ie, the joint probability of opposing counterfactuals P(Y_1=1 & Y_0=0) equals the difference of marginal probability P(Y_1=1) and, wait for it, P(Y_0=1)
010
Boris Sobolev @sobor.bsky.social · 18/11/2024
Please don't miss @eliasbareinboim chapter on @yudapearl causal hierarchy. I highly recommend it for the authors’ effort to give consistent notation, thoughtful examples, crisp statements. Such a powerful reading material that we can use in educational efforts.
030
Boris Sobolev @sobor.bsky.social · 18/11/2024
What if treatment were different? tiny.cc/soborisC10V1
221
Boris Sobolev @sobor.bsky.social · 08/11/2024
My browsing of UBC bookstore got me this! @alxndrmlk.bsky.social
170
Boris Sobolev @sobor.bsky.social · 01/12/2023
We invite PhD applications for Fall 2024 to study 𝘁𝗵𝗲 𝗵𝗲𝗮𝗹𝘁𝗵 𝗲𝗳𝗳𝗲𝗰𝘁𝘀 𝗼𝗳 𝗻𝘂𝘁𝗿𝗶𝘁𝗶𝗼𝗻 𝗽𝗼𝗹𝗶𝗰𝗶𝗲𝘀 in a research collaboration led by Dr. Mahsa Jessri @UBC. If you have unbridled enthusiasm for causal inference in policy evaluation and personalized recommendations, please DM me!
030