Reposted by Stephanie YanRajiv McCoy @rajivmccoy.bsky.social · 23/05/2025Congrats to Dr. @saracarioscia.bsky.social and Dr. Dylan Taylor!! 0333
Reposted by Stephanie YanSara Carioscia @saracarioscia.bsky.social · 16/05/2025I'm defending my PhD next Friday, May 23!(!!!!). I'll be highlighting our work looking at aneuploidy in early human development. If you're interested I'd love to have you join via Zoom (DM me for info) or on the Homewood campus! 2359
Stephanie Yan @smyan.bsky.social · 04/05/2025wouldn’t count out 24 chromosome bars for any other paper ❤️ 030
Reposted by Stephanie YanJeffrey Ross-Ibarra @jrossibarra.bsky.social · 16/04/2025Apparently not all my popgen advice is good. 3315
Reposted by Stephanie YanSara Carioscia @saracarioscia.bsky.social · 07/04/2025My main PhD work is up! See thread below. I would love to discuss! www.medrxiv.org/content/10.1...medrxiv.orgCommon variation in meiosis genes shapes human recombination phenotypes and aneuploidy riskThe leading cause of human pregnancy loss is aneuploidy, often tracing to errors in chromosome segregation during female meiosis. While abnormal crossover recombination is known to confer risk for ane... 0269
Reposted by Stephanie YanArjun Biddanda @aabiddanda.github.io · 07/04/2025Thrilled to see this work out - its been fascinating to look at statistical genetics in these IVF embryo datasets underlying meiotic aneuploidies and recombination! Joint work led with @saracarioscia.bsky.social. See thread below, thoughts welcome! www.medrxiv.org/content/10.1...medrxiv.orgCommon variation in meiosis genes shapes human recombination phenotypes and aneuploidy riskThe leading cause of human pregnancy loss is aneuploidy, often tracing to errors in chromosome segregation during female meiosis. While abnormal crossover recombination is known to confer risk for ane... 0247
Stephanie Yan @smyan.bsky.social · 07/04/2025huge congrats to @saracarioscia.bsky.social @aabiddanda.bsky.social Margaret and @rajivmccoy.bsky.social!!!! So excited to see this out! 050
Reposted by Stephanie YanChristina McNerney @christ3na.bsky.social · 24/03/2025Very excited to share (most of) my PhD work, in which we use human retinal organoids to understand how thyroid hormone signaling is regulated in the developing retina to promote robust and accurate photoreceptor subtype specification. Turns out, it's a lot more complicated than we expected. 1/n 2188
Reposted by Stephanie YanBob Johnston @bobbyjeyeguy.bsky.social · 01/04/2025Congrats to Brian Guy from my lab who became Dr. Guy PhD today!!! 2142
Reposted by Stephanie YanBob Johnston @bobbyjeyeguy.bsky.social · 24/03/2025Check out this tour de force work from @christ3na.bsky.social in my lab! Her studies reveal how developmental timing in the retina is controlled like an hourglass. The progenitor:neuron ratio shifts to control signaling levels and trigger photoreceptor development over time. Check it out!! 1259
Reposted by Stephanie YanSamuel Pattillo Smith @sampatsmith.bsky.social · 04/02/2025Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]biorxiv.orgA Litmus Test for Confounding in Polygenic ScoresPolygenic scores (PGSs) are being rapidly adopted for trait prediction in the clinic and beyond. PGSs are often thought of as capturing the direct genetic effect of one's genotype on their phenotype. ... 27638
Reposted by Stephanie YanMichael Hoffman @michaelhoffman.bsky.social · 06/11/2024Now: Rajiv McCoy: Genetic architecture of meiotic recombination across 90,431 in vitro fertilized embryos #ASHG24 🧪🧬🖥️eppro02.ativ.meEventPilot Web App 151
