iiinova — where your digital self keeps evolving

Jan Škoda @skodalab.bsky.social · 09/02/2025

Právě jsme s @lucieskodova.bsky.social shlédli - skvělé to bylo! 👏 Díky všem, co foukají do balónku 😉 @chmee2.bsky.social

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Jan Škoda @skodalab.bsky.social · 05/02/2025

🚨 We're hiring! A 2.5-year (full-time) #Postdoc position available in my lab @uebscimuni.bsky.social in Brno, Czechia. 👇 Apply now & join us to study mitochondrial synthetic lethality in MYC-driven tumors. 📅 Deadline: 21 March 2025. (official e-application link will follow) Please repost 💚

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Jan Škoda @skodalab.bsky.social · 30/01/2025

Zítra brzké vstávání ☕Moje žena si bude jako hlavní host Dobrého rána povídat o její práci ilustrátorky 🤩 Mám z toho upřímnou radost a jsem na ni fakt pyšný 😊 Mrkněte taky živě/ivysilani @ceskatelevize.cz. A pokud hledáte šikovnou ilustrátorku např. pro vědecké/popularizační projekty... 👇

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Jan Škoda @skodalab.bsky.social · 23/01/2025

What a great initiative and amazing resource for #ChildhoodCancer studies! Bookmarked & will definitely use in near future 👇

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Jan Škoda @skodalab.bsky.social · 23/01/2025

Very cool study, congrats!

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Jan Škoda @skodalab.bsky.social · 23/01/2025

A tremendous effort by the first author Lucie Curylova! 👏 Huge thanks to my team @MUNI @FNUSA-ICRC and all collaborators @FNBrno @CEITEC_MUNI. Funded by #AZVČR (Czech Health Research Council), with institutional support from the National Institute for Cancer Research & the Ministry of Health 🙏

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Jan Škoda @skodalab.bsky.social · 23/01/2025

Finally, as all patient-derived models were wild-type p53, our findings suggest that restoring p53 function could offer a promising strategy for treating refractory/metastatic p53-overexpressing pediatric sarcomas, regardless of their TP53 mutational status.

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Jan Škoda @skodalab.bsky.social · 23/01/2025

We tested this using paired models with different stemness levels. Our study shows for the first time that reactivating p53 signaling via MDM2/MDMX inhibition selectively induces cell death in aggressive, stem-like Ewing's sarcoma cells while sparing healthy fibroblasts.

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Jan Škoda @skodalab.bsky.social · 23/01/2025

Indeed, SOX2 was detected only in human Ewing‘s sarcoma samples that overexpressed p53, indicating disruption of the p53 pathway. Moreover, altered p53 expression was prevalent in metastatic tumors, suggesting p53 as a clinically relevant target for reactivation therapies.

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Jan Škoda @skodalab.bsky.social · 23/01/2025

Only cells with high SOX2 or KLF4 expression, along with p53 dysregulation, formed tumors in mice. SOX2 knockdown on a mutant p53 background reduced, but didn’t prevent self-renewal, suggesting p53 dysregulation is crucial for sarcoma cells to acquire a fully stem-like phenotype.

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Jan Škoda @skodalab.bsky.social · 23/01/2025

Using a large panel of pediatric sarcoma models, in vivo assays, and tumor tissues, our study provides strong evidence that dysregulated p53 associates with the upregulation of stemness-related transcription factors and enhanced tumorigenicity in pediatric sarcoma cells.

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Jan Škoda @skodalab.bsky.social · 23/01/2025

Pediatric sarcomas are bone & soft tissue tumors that often metastasize and show therapy-resistant cancer stem cell traits, making treatment challenging. An impaired p53 pathway is common in aggressive sarcomas, yet its link to sarcoma stemness has been unclear.

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Jan Škoda @skodalab.bsky.social · 23/01/2025

🥳 Excited to share our new paper on #pediatric #sarcomas! Restoring p53 tumor suppressor activity offers a promising approach to target aggressive, cancer stem-like cells in these childhood tumors: rdcu.be/d2ufo @MUNI @FNUSA-ICRC @agentura_azvcr (not yet here) 🧵1/n👇

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Dysregulation of the p53 pathway provides a therapeutic target in aggressive pediatric sarcomas with stem-like traits

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Jan Škoda @skodalab.bsky.social · 23/01/2025

Hi Bluesky! This is us, #ChildhoodCancer #Mitochondria #CancerStemCells #PrecisionMedicine maniacs. First post as we start fresh from scratch 😉 Still missing so many great accounts here, but let’s get things rolling! Excited to share and discover interesting content again. The sky’s the limit! 🚀

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Reposted by Jan Škoda

Eric Topol @erictopol.bsky.social · 22/01/2025

A new mechanism for cancer-induced immune evasion. We knew about cancer cells hijacking mitochondria. Now we learn about how their mitochondrial transfer to T cells impairs the tumor immune response. www.nature.com/articles/s41... www.nature.com/articles/d41...

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