iiinova — where your digital self keeps evolving

Reposted by Siyu He

Irving Institute for Cancer Dynamics @cancerdynamics.bsky.social · 10/11/2025

New paper out in @natmethods.nature.com from @elhamazizi.bsky.social, Kam Leong & @jameszou.bsky.social! The team developed Squidiff, a diffusion #AI model to predict cellular responses to environmental cues and accelerate #PrecisionMedicine. Learn more: bit.ly/3WRPNsx

Schematic of cell differentiation prediction (a) and drug response prediction (b).

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Reposted by Siyu He

Irving Institute for Cancer Dynamics @cancerdynamics.bsky.social · 13/05/2025

Missed last week’s #CompSpatialBio seminar @justjhong.bsky.social with @siyuhe.bsky.social on CORAL—a deep graph model for spatial-omics? The recording is now available: youtu.be/BV5soaUVUNA 📅 Stay tuned for the next session! csbseminar.github.io

youtu.be

Learning single-cell spatial context through integrated spatial multiomics with CORAL - Siyu He

YouTube video by Computational Spatial Biology seminar

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Siyu He @siyuhe.bsky.social · 24/04/2025

Thanks @justjhong.bsky.social for the invitation! Looking forward to the discussion.

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Reposted by Siyu He

zhoujt.bsky.social @zhoujt.bsky.social · 25/03/2025

1/10 Excited to share our latest - the first whole-body map of both DNA methylation and 3D genome at single-cell resolution.

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Reposted by Siyu He

Naveed Tavakol @naveedtavakol.bsky.social · 24/02/2025

Check out our new collaborative work with Dr. Kam Leong @columbiauniversity.bsky.social now out in Advanced Functional Materials! We developed oral nanoparticles to help mitigate hematopoietic acute radiation syndrome, especially in cases of deep space exploration: t.co/1jQwcU1pDB

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Siyu He @siyuhe.bsky.social · 08/02/2025

Thrilled to introduce #CORAL🪸—a deep probabilistic graphical model that integrates spatial multiomics data! 🔹Resolves spatial resolution discrepancies across modalities 🔹Deconvolutes low-res data to achieve single-cell granularity 🔹Enables parallel integrative analysis 1/🪸

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Siyu He @siyuhe.bsky.social · 09/12/2024

We are thrilled to share #Squidiff 🦑, a conditional diffusion model, which generates new transcriptomes that represent distinct cellular states, and its application to cell differentiation and drug perturbation www.biorxiv.org/content/10.1... 1/🦑

tinyurl.com

Squidiff: Predicting cellular development and responses to perturbations using a diffusion model

Single-cell sequencing has revolutionized our understanding of cellular heterogeneity and responses to environmental stimuli. However, mapping transcriptomic changes across diverse cell types in respo...

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