iiinova — where your digital self keeps evolving

SimulAdrenTeam @simuladrenteam.bsky.social · 29/08/2026

#SimulAdren has been upgraded to version 2.1, introducing a cosinor-based model for circadian #CRH secretion, speed improvements and bug fixes. #HPA axis, #adrenal homeostasis, #corticotropic feedback control simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Screenshot of SimulAdren 2.1.0 on macOS 26.6.1.

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SimulAdrenTeam @simuladrenteam.bsky.social · 24/05/2026

#SimulAdren, the open dynamic simulator for the #HPA-axis, i. e. the #hypothalamus-pituitary-adrenal feedback control, has been released in version 2.0.1. This is a recommended update that fixes several bugs. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Screenshot of SimulAdren Rubycon 2.0.1 on macOS Tahoe 26.4.1.

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Johannes W. Dietrich @drjwdietrich.bsky.social · 06/12/2024

Hier ein Beispiel für eine berühmte Simulation mit einem #Analogrechner: Das Modell der #Insulin-Glukose-Homöostase von Bolie (1960). Dieses Modell hatte einen enormen Einfluss auf unser Verständnis des #Diabetes mellitus und lässt sich mit modernen Analogrechnern jetzt wieder direkt reproduzieren.

Bolies Modell der Insulin-Glukose-Homöostase auf dem Analogrechner THE ANALOG THING. Im Hintergrund ein Oszilloskop zur Ausgabe der Daten und ein MacBook Air, das für die Simulation nicht notwendig ist, aber erklärende Informationen zeigt (aus meiner Vorlesung "Metabolische Kybernetik und Systemendokrinologie").

Model of insulin-glucose homeostasis by Victor W. Bolie (1960 and 1961) simulated on a modern analog computer (anabrid THE ANALOG THING). In the background an oscilloscope by PeakTech and a MacBook Air M2 illustrating supporting information.

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SimulAdrenTeam @simuladrenteam.bsky.social · 24/03/2026

#SimulAdren underwent a major upgrade. Version 2.0 introduces significant new features, e.g., support for different models, initial conditions, first-order delay kinetics (ASIA elements), and model continuation. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Screenshot of SimulAdren 2.0 (Rubycon) on macOS 13.7 (Ventura).

Screenshot of SimulAdren 2.0 (Rubycon) on Windows 11

Screenshot of SimulAdren 2.0 (Rubycon) on Fedora Linux 38

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CyberUnits Team @cyberunitsteam.bsky.social · 13/03/2026

#SimulAdren, based on #CyberUnits Bricks, has been upgraded to version 1.3 (Green Lizard). This version introduces functionality to save plots and the block diagram of the information processing structure as graphics files. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Screenshot of SimulAdren 1.3 (Green Lizard) on macOS Ventura 13.7.8

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Scientific Pascal @scipastips.bsky.social · 27/01/2026

#SimulAdren is a simulation program for the #hypothalamus - #pituitary - #adrenal feedback control, an essential physiological motif. It is written in #Object_Pascal and helps to understand life-threatening diseases.

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CyberUnits Team @cyberunitsteam.bsky.social · 27/01/2026

#Simuladren, a simulator for the #HPA axis based on #CyberUnits Bricks, has been updated to version 1.2. This upgrade introduces support for XML files according to #MIASE and #MIRIAM guidelines and high-res displays on Windows. simuladren.sourceforge.io doi.org/10.5281/zeno...

Screenshot of SimulAdren 1.2 (Emerald) on macOS 13.7 Ventura.

Screenshot of SimulAdren 1.2 (Emerald) on Windows 11.

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CyberUnits Team @cyberunitsteam.bsky.social · 13/12/2025

#SimulAdren has been released in version 1.1. This cross-platform simulator of the corticotropic feedback loop (hypothalamus-pituitary-adrenal or #HPA axis) is based on the #CyberUnits Bricks class library. doi.org/10.5281/zeno... doi.org/10.5281/zeno... simuladren.sf.net

Screenshot of SimulAdren 1.1.0 on macOS 13.7.8

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Scientific Pascal @scipastips.bsky.social · 04/01/2025

For a completely different task, simulating biological feedback loops, #Object_Pascal generates the fastest code. It is not only faster than that of interpreted languages (S/R and Python) but even outperforms fast compiled languages (C++ and Swift). #Pascal #programming doi.org/10.14201/adc...

Figure: Benchmarking results of code generated in five different programming languages (S/R, Python, Swift, C++ and Object Pascal) for simulation of two different types of feedback control systems. Object Pascal generates the by far fastest code.

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Scientific Pascal @scipastips.bsky.social · 04/01/2025

In scientific computing, speed is critical when choosing a programming language. Additionally, given limited resources for funding and the challenges of climate change, memory and energy efficiency are important as well. #Pascal is in the Pareto-optimal set of these goals. doi.org/10.1016/j.sc...

Table: Pareto-optimal sets of programming languages. Concerning time & memory, energy & memory and energy & time & memory, Pascal is in the top group.

For the QuickSort algorithm, Pascal is the fastest and most energy-efficient programming language.

Pascal is the fastest and most energy-efficient programming language for finding primes with the Sieve of Eratosthenes algorithm.

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