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SimulAdrenTeam @simuladrenteam.bsky.social · 29/08/2026

#SimulAdren has been upgraded to version 2.1, introducing a cosinor-based model for circadian #CRH secretion, speed improvements and bug fixes. #HPA axis, #adrenal homeostasis, #corticotropic feedback control simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Screenshot of SimulAdren 2.1.0 on macOS 26.6.1.

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CyberUnits Team @cyberunitsteam.bsky.social · 21/08/2026

#CyberUnits Bricks has been upgraded to version 2.2.0 (Graffiti Street). It introduces a cosinor-based class for #Object_Pascal to simulate chronobiological rhythms, and fixes several bugs. cyberunits.sourceforge.net doi.org/10.5281/zeno... codeberg.org/jwdietrich/c... github.com/jwdietrich21...

Screenshot of a demonstration program for CyberUnits Bricks' cosinor class.

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SimulAdrenTeam @simuladrenteam.bsky.social · 24/05/2026

#SimulAdren, the open dynamic simulator for the #HPA-axis, i. e. the #hypothalamus-pituitary-adrenal feedback control, has been released in version 2.0.1. This is a recommended update that fixes several bugs. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Screenshot of SimulAdren Rubycon 2.0.1 on macOS Tahoe 26.4.1.

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Johannes W. Dietrich @drjwdietrich.bsky.social · 20/03/2026

Mathematical modelling, computer #simulation, and machine learning upgrade #endocrinology. Applying principles of #biocybernetics and #biophysics, they enjoy growing interest and deliver novel methods for research, diagnosis, and therapy. pubmed.ncbi.nlm.nih.gov/41852474/ doi.org/10.3389/fend...

Two bar plots from the paper:

Yearly numbers of publications in PubMed from 1965 to 2025 on mathematical modelling in endocrinology and diabetes with (left) and without (right) machine learning.

Search terms were “(“mathematical modelling” OR “computer simulation” OR “machine learning”) AND (endocrinology OR endocrine OR hormone OR hormonal OR diabetes)” for the left plot and “(“mathematical modelling” OR “computer simulation”) AND (endocrinology OR endocrine OR hormone OR hormonal OR diabetes)” for the right plot.

The left chart shows a dramatic increase, peaking sharply in the year 2025 at nearly 3000 publications. The right chart shows moderate growth with peaks around four hundred around the year 2025.

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CyberUnits Team @cyberunitsteam.bsky.social · 13/03/2026

#SimulAdren, based on #CyberUnits Bricks, has been upgraded to version 1.3 (Green Lizard). This version introduces functionality to save plots and the block diagram of the information processing structure as graphics files. simuladren.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Screenshot of SimulAdren 1.3 (Green Lizard) on macOS Ventura 13.7.8

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CyberUnits Team @cyberunitsteam.bsky.social · 27/01/2026

#Simuladren, a simulator for the #HPA axis based on #CyberUnits Bricks, has been updated to version 1.2. This upgrade introduces support for XML files according to #MIASE and #MIRIAM guidelines and high-res displays on Windows. simuladren.sourceforge.io doi.org/10.5281/zeno...

Screenshot of SimulAdren 1.2 (Emerald) on macOS 13.7 Ventura.

Screenshot of SimulAdren 1.2 (Emerald) on Windows 11.

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CyberUnits Team @cyberunitsteam.bsky.social · 27/01/2026

#CyberUnits Bricks has been released in version 2.1.0. This version introduces a proportional-integral (PI) block, scaling for systems diagrams, a solver for algebraic equations, extended ASIA elements, additional demo programs, and bug fixes. cyberunits.sf.net doi.org/10.5281/zeno...

CyberUnits Bricks: Screenshot of a demo app for a feedback loop with a dead-time element.

CyberUnits Bricks: Screenshot of unit tests for the solver unit.

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CyberUnits Team @cyberunitsteam.bsky.social · 13/12/2025

#SimulAdren has been released in version 1.1. This cross-platform simulator of the corticotropic feedback loop (hypothalamus-pituitary-adrenal or #HPA axis) is based on the #CyberUnits Bricks class library. doi.org/10.5281/zeno... doi.org/10.5281/zeno... simuladren.sf.net

Screenshot of SimulAdren 1.1.0 on macOS 13.7.8

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Johannes W. Dietrich @drjwdietrich.bsky.social · 07/09/2025

Are you researching #endocrine #feedback control systems? Our Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" is still open for submission. www.frontiersin.org/research-top... #endocrinology #cybernetics

Screenshot of the web site of the Research Topic "Mechanistic, Machine Learning and Hybrid Models of the 'Other' Endocrine Regulatory Systems in Health and Disease: Volume II" in Frontiers in Systems Endocrinology

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Brian Cardone @cardonebrian.bsky.social · 18/06/2025

🚨🚨The White House is pissed off about this ad so you know what to do, share it everywhere! ICE is disappearing people just because of the color of their skin! No Warrant! No Due Process! This is not who we are as Americans! #MAGAKidnappers want an all white America, fuck that‼️

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Scientific Pascal @scipastips.bsky.social · 04/01/2025

For a completely different task, simulating biological feedback loops, #Object_Pascal generates the fastest code. It is not only faster than that of interpreted languages (S/R and Python) but even outperforms fast compiled languages (C++ and Swift). #Pascal #programming doi.org/10.14201/adc...

Figure: Benchmarking results of code generated in five different programming languages (S/R, Python, Swift, C++ and Object Pascal) for simulation of two different types of feedback control systems. Object Pascal generates the by far fastest code.

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Scientific Pascal @scipastips.bsky.social · 04/01/2025

In scientific computing, speed is critical when choosing a programming language. Additionally, given limited resources for funding and the challenges of climate change, memory and energy efficiency are important as well. #Pascal is in the Pareto-optimal set of these goals. doi.org/10.1016/j.sc...

Table: Pareto-optimal sets of programming languages. Concerning time & memory, energy & memory and energy & time & memory, Pascal is in the top group.

For the QuickSort algorithm, Pascal is the fastest and most energy-efficient programming language.

Pascal is the fastest and most energy-efficient programming language for finding primes with the Sieve of Eratosthenes algorithm.

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Scientific Pascal @scipastips.bsky.social · 04/01/2025

program NewYear; uses SysUtils, DateUtils; var currDate: TDateTime; currYear, currMonth, currDay: Word; begin currDate := now; DecodeDate(currDate, currYear, currMonth, currDay); Writeln('Happy new year ' + IntToStr(currYear) + '!'); end.

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CyberUnits Team @cyberunitsteam.bsky.social · 28/09/2024

#CyberUnits Bricks was at the centre of the keynote lecture by Johannes W. Dietrich at the International Pascal Congress 2023. Now the recordings are available online from youtu.be/RZ9iu_jaAcg?... 🧪🩺

youtu.be

"Shaping Systems Endocrinology with Object Pascal " by Dr. Johannes W. Dietrich

YouTube video by IPC (International Pascal Congress)

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Hacker News Top 100 Bot (Unofficial) @hn100.bsky.social · 07/02/2024

Advantages of the Free Pascal Compiler Discussion

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Scientific Pascal @scipastips.bsky.social · 31/08/2024

When it comes to performance, #Object_Pascal is a preferable programming language for computer #simulations in life sciences.

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Johannes W. Dietrich @drjwdietrich.bsky.social · 31/08/2024

Which programming language is fit for high-performance computer simulations in biomedical #cybernetics? We found that #Free_Pascal generates faster code than S/R and #Python. Interestingly, Object #Pascal even outperforms #Swift and C++. 🧪🩺 doi.org/10.14201/adc... revistas.usal.es/cinco/index....

Simulation speed with implementations in different programming languages. Shown is the time needed to simulate a first-order linear feedback loop (A) and a zeroth-order MiMe-NoCoDI loop (B) dependent on the number of iterations (proportional to simulated time, abscissa) based on implementations of the simulation program and the CyberUnits Bricks library in S, Python, Swift, C++ and Object Pascal. The ordinate is logarithmically scaled and represents the mean of 10 replications of each number of iteration steps.

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CyberUnits Team @cyberunitsteam.bsky.social · 31/08/2024

#CyberUnits Bricks was the basis of an implementation and performance study that has recently been published in ADCAIJ (Advances in Distributed Computing and Artificial Intelligence Journal). revistas.usal.es/cinco/index.... doi.org/10.14201/adc...

Class hierarchy of the CyberUnits Bricks library, showing inheritance in the Bricks, LifeBlocks and SystemsDiagram units.

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SimulaBetaTeam @simulabetateam.bsky.social · 03/01/2024

#SimulaBeta 3.1.2 is available. This service release fixes several bugs and is the first version to be based on #CyberUnits Bricks 2.0. simulabeta.sourceforge.io doi.org/10.5281/zeno... doi.org/10.5281/zeno...

Screenshot of SimulaBeta 3.1.2 on macOS Ventura 13.4.1

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