Happy to share the 1st paper of my postdoc, finding elevated Rab phosphorylation in neurodegenerative diseases and association with granulovacuolar degeneration! Thanks to Dr. Sanders' mentorship and @parkinsondotorg.bsky.social @pfresearchteam.bsky.social support! link.springer.com/article/10.1...
link.springer.com
LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies - Acta Neuropathologica
Parkinson’s disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with endolysosomal dysfunction across cell types, and carriers of LRRK2 mutations variably present ...