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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 7h

Know how #VEGF signaling regulates vascular remodeling in health and disease. This review examines molecular mechanisms, therapeutic resistance, and emerging combination and drug delivery strategies for #Angiogenesis-related diseases. #STTT #OpenAccess: doi.org/10.1038/s413...

Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 10h

How does SRSF11 #Succinylation drive #Radioresistance in #LiverCancer? This study shows that KAT2A promotes RAD52 splicing and RAD51-dependent DNA repair, identifying a potential target for radiosensitization. #STTT #OpenAccess: doi.org/10.1038/s413... #CancerDiagnosis #AIinMedicine

KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma

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ESMO - European Society for Medical Oncology @myesmo.bsky.social · 16/10/2026

One week to go until #ESMO26 Share your research or clinical highlights and key takeaways with the #OncologyCommunity. Use #ESMO26 in your posts to be part of the scientific conversation and connect with colleagues from around the world.

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ESMO - European Society for Medical Oncology @myesmo.bsky.social · 16/10/2026

ESMO Fellowship session at #ESMO26: stories, perspectives, hopes and reflections from past and present fellows. A unique source of inspiration for #YoungOncologists. 🔗 ow.ly/n7IX50ZXGhR #ESMOFellowships #CareerDevelopment

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American Association for Cancer Research (AACR) @theaacr.bsky.social · 16/10/2026

Submit an abstract by October 21 for the AACR Special Conference on Cancer Biology-informed Radioligand Therapy (January 7-10; San Diego), chaired by Kayvan Keshari, David Piwnica-Worms, Julie L. Sutcliffe, and David A. Tuveson. buff.ly/gVPJ8ey #aacrRLT27

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 16h

Dual #Autophagy activation improves #AlzheimersDisease. Presenting AR7 & rapamycin- delivering #Microglia-derived nanovesicles that synchronously activate autophagy & macroautophagy, enhancing amyloid clearance and cognition. #STTT #OpenAccess: doi.org/10.1038/s413...

Microglia-derived nanovesicles synchronize macroautophagy and chaperone-mediated autophagy for Alzheimer’s disease therapy

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 20h

Can targeting lipid metabolism improve treatment of SDH-deficient gastrointestinal stromal tumors? This phase 1b study reports promising activity of olverembatinib, which suppresses CD36 expression and lipid uptake. #STTT #OpenAccess: doi.org/10.1038/s413... #CancerMetabolism #LipidUptake

Olverembatinib, a multikinase inhibitor that modulates lipid metabolism, in advanced succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 1b study and translational research

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 16/10/2026

Accurate diagnosis of pulmonary nodules is a challenge in early #LungCancer detection. This review explores imaging, #Biomarkers, molecular pathways, and AI-assisted risk assessment to guide early diagnosis and management. #STTT #OpenAccess: doi.org/10.1038/s413...

Pulmonary nodules: classification, biomarkers, signaling pathways, diseases, early diagnosis and management

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 16/10/2026

#AcneVulgaris presents significant clinical challenges and psychological comorbidities that demand precision therapeutic strategies. This review explores molecular mechanisms, emerging biologics, and novel #Vaccines. #STTT #OpenAccess: doi.org/10.1038/s413... #CellSignaling #TherapeuticTargets

Acne: epidemiology, risk factors, pathogenesis, management and cutting-edge research

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 16/10/2026

#ChronicPain is a major global health challenge requiring precise molecular insights & innovative therapeutics. This work reviews neural circuit mechanisms, current therapeutic interventions, and emerging #Neuromodulation strategies. #STTT #OpenAccess: doi.org/10.1038/s413... #CellSignaling

Progress in pain mechanisms and management

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 16/10/2026

Hydrogen peroxide functions as a key second messenger orchestrating essential cellular signaling pathways in health and disease. This review outlines emerging therapeutic strategies targeting redox systems. #STTT #OpenAccess: doi.org/10.1038/s413... #RedoxSignaling #HydrogenPeroxide #RedoxBiology

Hydrogen peroxide sensing and signaling in physiology and disease: implications for therapy

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 15/10/2026

Can host lipid metabolism help combat drug-resistant #Biofilms? This study shows that rhein activates LDLR-mediated fatty acid production, enabling synergy with silver ions to suppress biofilms and promote #DiabeticWoundHealing. #STTT #OpenAccess: doi.org/10.1038/s413...

Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 15/10/2026

Advanced #SCLC requires innovative therapeutic strategies beyond standard #Chemoradiotherapy. A randomized trial reports improved progression-free and overall survival with camrelizumab-based induction and consolidation therapy. #STTT #OpenAccess: doi.org/10.1038/s413... #CancerResearch

Camrelizumab plus chemotherapy as induction therapy followed by concurrent chemoradiotherapy and camrelizumab consolidation in limited-stage small cell lung cancer: a randomized phase II trial

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American Association for Cancer Research (AACR) @theaacr.bsky.social · 14/10/2026

Theranostics Revolution: Seeing, Targeting, Treating— Jason S. Lewis will address this topic in a keynote lecture at the AACR Conference on Cancer Biology-informed Radioligand Therapy (January 7-10; San Diego). Learn more: buff.ly/2nPh5AX #aacrRLT27 @lewislabmskcc.bsky.social

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American Association for Cancer Research (AACR) @theaacr.bsky.social · 14/10/2026

Submit an abstract by October 29 for the AACR Special Conference on Redefining Lung Cancer (January 14-17; San Diego), held in association with the AACR Lung Cancer Task Force and chaired by Charles Swanton. Learn more: buff.ly/keg0wCw #AACRlung27

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OncLive @onclive.bsky.social · 14/10/2026

🧠 The cancer vaccine SurVaxM generated a clinically meaningful OS improvement vs placebo in newly diagnosed glioblastoma, although the SURVIVE trial did not reach its primary end point. @roswellpark.bsky.social #btsm #oncology Full story ➡️: www.onclive.com/view/survaxm...

onclive.com

SurVaxM Cancer Vaccine Shows Clinically Meaningful OS Signal in Newly Diagnosed Glioblastoma | OncLive

SurVaxM missed the SURVIVE trial OS end point in newly diagnosed glioblastoma, whereas a subgroup of patients 65 or younger had significantly improved OS.

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 15/10/2026

Can dual cytokine blockade address treatment-resistant #HidradenitisSuppurativa? This study identifies an IL-17/IL-36γ inflammatory hub and demonstrates promising clinical responses and tunnel regression with the #BispecificAntibody HB0043. #STTT #OpenAccess: doi.org/10.1038/s413...

Targeting an IL-17/IL-36 pathogenic hub in hidradenitis suppurativa with a bispecific antibody

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 15/10/2026

Learn how protein stabilization protects against #PulmonaryFibrosis. Nedd4L promotes K63-linked BMPR2 #Ubiquitination, counteracts #LipidPeroxidation-induced degradation, and preserves antifibrotic BMP/Smad signaling. #STTT #OpenAccess: doi.org/10.1038/s413...

Nedd4L-mediated stabilization of morphogenetic protein receptor 2 in lung fibroblasts confers protection against pulmonary fibrosis

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 14/10/2026

How does dysregulated RTK signaling contribute to disease? This review examines RTK interactions with #GPCR, Wnt, and TGF-β pathways and their implications for #Cancer progression and targeted therapeutic development. #STTT #OpenAccess: doi.org/10.1038/s413...

Targeting receptor tyrosine kinases: from molecular mechanisms to clinical therapeutics

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 14/10/2026

How does tumor metabolism contribute to immune escape? This review defines metabolic immune checkpoints involving protein modifications, metabolic enzymes, and microbial metabolites as potential #Immunotherapy targets. #STTT #OpenAccess: doi.org/10.1038/s413... #Immunometabolism #ImmuneEscape

Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 13/10/2026

How can #Bioengineering improve #mRNAvaccine #Immunogenicity? This review explores how RNA architecture and delivery platforms coordinate antigen expression, innate immune activation, and adaptive immune responses. #STTT #OpenAccess: doi.org/10.1038/s413... #Immunogenicity #VaccineDevelopment

Bioengineering strategies for improving the immunogenicity of mRNA vaccines

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 13/10/2026

Pulmonary hypoxia and #Inflammation may influence dormant tumor growth. #SARSCoV2 infection activates #VEGF–VEGFR2 signaling, driving angiogenesis and tumor outgrowth in animal models, which VEGF blockade suppresses. #STTT #OpenAccess: doi.org/10.1038/s413... #CancerResearch

COVID-19 triggers pulmonary tumor outgrowth through hypoxia- and inflammation-induced VEGF-dependent angiogenesis

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 13/10/2026

This study shows that #eccDNA-derived circular MIR144 drives age-related #CardiacRemodeling by inducing cardiomyocyte senescence and by promoting interstitial fibrosis and systolic dysfunction in mice. #STTT #OpenAccess: doi.org/10.1038/s413... #CardiacFibrosis #CellularSenescence

Circular MIR144 from eccDNA is a superior senescence agonist in aging hearts

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 13/10/2026

How might #SARSCoV2 contribute to β-cell failure? Viral spike and nucleocapsid proteins seed IAPP #Amyloid aggregation, disrupting #Insulin granule maturation and secretion in an age-susceptible islet environment. #STTT #OpenAccess: doi.org/10.1038/s413...

SARS-CoV-2 seeds IAPP aggregation and β-cell failure

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American Association for Cancer Research (AACR) @theaacr.bsky.social · 12/10/2026

Register by November 2 to get the lowest available rates for the San Antonio Breast Cancer Symposium (December 8-11), presented by UT Health San Antonio in collaboration with the AACR. Learn more: buff.ly/ZJJqL8Y #SABCS26

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American Society of Clinical Oncology @ascocancer.bsky.social · 12/10/2026

The full 700+ abstracts for #ASCOQLTY26 are now available! Check out the latest science on quality, safety, and efficiency in #CancerCare delivery. Late-breaking abstracts will be released at 7 AM (ET) on their presentation day. View the full abstracts here: bit.ly/3TwmKN6

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ESMO - European Society for Medical Oncology @myesmo.bsky.social · 13/10/2026

👉 Explore cutting-edge science in #AI, #CancerVaccines, biomarkers and next-generation #CellTherapies. 🔗 ow.ly/GoNr50ZWjzP Register now and secure the best available rates. #ESMOMeetings

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 12/10/2026

This review explores how local, reflex-level, and central #Neuroimmune interactions influence #Tumors, immune-related disorders, and #Infections, identifying therapeutic opportunities and challenges in clinical translation. #STTT #OpenAccess: doi.org/10.1038/s413...

Neuro-immune interactions in tumors, immune-related disorders, and infections

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 12/10/2026

Researchers reveal how glycerol-derived lactate drives H4K5 histone #Lactylation and a FOXP3–GK feedback loop in regulatory T cells, enhancing #Immunosuppression in #ColorectalCancer liver metastases. #STTT #OpenAccess: doi.org/10.1038/s413...

Histone H4K5 lactylation-driven feedback loop modulates glycerol-linked immunosuppressive activity of tumor-associated T regulatory cells

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 12/10/2026

#WorldArthritisDay | October 12 #Arthritis research is uncovering inflammatory pathways and molecular targets that could advance diagnosis and targeted treatment. #STTT explores signal transduction and targeted therapies across human diseases. Read recent research: www.nature.com/sigtrans/

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 12/10/2026

Using comprehensive #Multiomics analyses, researchers identify PLPP2-mediated phosphatidylethanolamine biosynthesis as a driver of #LiverRegeneration by promoting GLI1 stabilization and #Autophagy while alleviating #ERstress. #STTT #OpenAccess: doi.org/10.1038/s413...

Phospholipid phosphatase 2 drives liver repair and regeneration after acute liver injury

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 12/10/2026

How does α7 integrin drive HPV-negative head and neck cancer (#HNSCC)? Researchers reveal that ITGA7 regulates chromatin accessibility and gene expression through an AURKA-centered axis, identifying a potential #TherapeuticTarget. @tudresden.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413...

α7 integrin co-regulates chromatin accessibility and gene expression in HPV-negative head and neck cancer

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 11/10/2026

Researchers reveal how #Connexin43-mediated mitochondrial transfer from mesenchymal stem cells activates PGC1α signaling, reducing #OxidativeStress and #Inflammation to improve renal recovery after #Ischemia-reperfusion injury. #STTT #OpenAccess: doi.org/10.1038/s413...

Connexin 43-dependent mesenchymal stem cell mitochondrial transfer activates PGC1α disrupting oxidative-inflammation axis in ischemia-reperfusion injury

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 11/10/2026

To overcome tumor immune evasion, researchers engineered NK cells that target PD-L1, block NKG2A/HLA-E inhibitory signaling, and produce IL15 to improve antitumor activity, survival, and metabolic fitness. #OpenAccess: doi.org/10.1038/s413... #TumorImmunology #CellTherapy #ImmunoOncology

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EANO @eanoassociation.bsky.social · 08/10/2026

The scientific programme for the EANO-EORTC CNS Metastasis Meeting 2027 is taking shape and it reflects the multidisciplinary approach needed to tackle one of oncology's greatest challenges. Explore the programme and register today: www.eano.eu/eanomeetings... #CNSmetastasis2027 @eortc.org

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EACR - European Association for Cancer Research @helloeacr.bsky.social · 09/10/2026

ecDNA and the Genomic Chaos of Cancer | Virtual Event: 23-24 Feb 2027 Recent recognition of ecDNA’s enabling role as a hallmark of cancer, particularly as it results from genome instability, has highlighted the critical need to better understand its underlying biology. eacr.org/conference/e...

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OncLive @onclive.bsky.social · 09/10/2026

📰 The Guardant360 CDx has received EU approval as a companion diagnostic to identify patients with ER+, HER2– locally advanced or metastatic breast cancer who may benefit from camizestrant. #bcsm #oncology Full story ➡️: www.onclive.com/view/guardan...

onclive.com

Guardant360 CDx Receives European Approval as Companion Diagnostic for Camizestrant in ESR1-Mutated Advanced Breast Cancer | OncLive

The liquid biopsy identifies ESR1 mutations in blood to select patients with metastatic breast cancer who may be eligible for treatment with camizestrant.

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 11/10/2026

Post-translational modifications can coordinate metabolic and immune adaptation in #Cancer. This review links PTM networks to metabolic flux, cell fate, #ImmuneEvasion, and emerging targets for metabolic therapy and #Immunotherapy. #STTT #OpenAccess: doi.org/10.1038/s413...

Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 11/10/2026

How does immune cell trafficking shape tumors and #Inflammation? This review explores immune reservoirs, chemokine signaling, adhesion, metabolism, and #Microbiota as regulators and therapeutic targets for precision #Immunomodulation. #STTT #OpenAccess: doi.org/10.1038/s413...

Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 10/10/2026

How do intrinsic and acquired mechanisms drive cancer drug resistance? This review details the mechanisms underlying resistance, highlighting emerging therapeutic strategies for overcoming resistance in #PrecisionOncology. #STTT #OpenAccess: doi.org/10.1038/s413... #CancerResearch #Oncology

Cancer drug response and resistance: molecular mechanisms and combating strategies

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 10/10/2026

#Mitochondrial dysfunction contributes significantly to human disease pathogenesis. This review connects #proteostasis, biogenesis, mitochondrial dynamics, and mitophagy with disease mechanisms and emerging therapeutic strategies. @ub.edu #STTT #OpenAccess: doi.org/10.1038/s413...

Mitochondrial quality control in health and disease: mechanisms and therapeutic targets

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 10/10/2026

#Mucosaltissues serve as primary pathogen entry points requiring specialized defenses. A review of the immune mechanisms and #Vaccine delivery platforms that elicit local & systemic responses, as well as the challenges for next-gen #MucosalVaccines. #STTT #OpenAccess: doi.org/10.1038/s413...

Mucosal immunity and vaccine development

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 10/10/2026

#TumorHeterogeneity challenges antigen-specific #Vaccination. This review explores how in situ #CancerVaccines combine immunogenic cell death, advanced delivery, microenvironment modulation, and checkpoint blockade to broaden antitumor immunity. #STTT #OpenAccess: doi.org/10.1038/s413...

Combinatorial in situ cancer vaccines: unlocking broad and enhanced antitumor responses

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 09/10/2026

How can next-generation personalized #CancerVaccines overcome #Immunosuppressive microenvironments? This review evaluates mRNA, DNA, and #Nanovaccine platforms combined with checkpoint inhibitors for durable immunity. #STTT #OpenAccess: doi.org/10.1038/s413... #CancerStemness

Personalized cancer vaccines: bridging immune-oncology and precision medicine for advanced therapeutics

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 09/10/2026

This review links genomic and #Epigenetic changes, metabolic adaptation, immune escape, and therapy-driven selection to emerging evolution-guided strategies for #PrecisionOncology. @fudan-university.bsky.social #STTT #OpenAccess: doi.org/10.1038/s413... #CancerStemness

Tumor evolution: signaling pathways, molecular mechanisms and therapeutic targets

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OncLive @onclive.bsky.social · 08/10/2026

🗞️ Just in: The phase 3 EXCALIBER-RRMM trial met its second dual primary end point, with iberdomide plus daratumumab/dexamethasone extending PFS vs DVd in patients with R/R multiple myeloma #mmsm #oncology Read more: www.onclive.com/view/iberdom...

onclive.com

Iberdomide Plus Daratumumab/Dexamethasone Yields Significant PFS Benefit in R/R Myeloma | OncLive

Iberdomide plus daratumumab/dexamethasone improved PFS vs DVd in relapsed/refractory multiple myeloma, meeting a dual primary end point of EXCALIBER-RRMM.

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EACR - European Association for Cancer Research @helloeacr.bsky.social · 08/10/2026

The EACR 2027 Congress Call for Abstracts is now online! Explore the abstract topics and start planning what you might present in Bilbao in June: 2027.eacr.org/abstracts

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American Association for Cancer Research (AACR) @theaacr.bsky.social · 08/10/2026

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 09/10/2026

ENO1 connects #Glycolysis with #GastricCancer stemness by regulating ATP pools and lactate homeostasis, which coordinate AMPK/mTOR and PI3K/AKT signaling to promote EMT, self-renewal, migration, and invasion. #STTT #OpenAccess: doi.org/10.1038/s413... #CancerStemness

Alpha-enolase influences ATP pool of cytoplasm and lactate homeostasis by regulating glycolysis in gastric cancer

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Signal Transduction and Targeted Therapy @sigtrans-sttt.bsky.social · 09/10/2026

Can light power stressed #Mitochondria? Engineered mt-EcGAPR uses ambient light to enhance ATP production and reduce ROS, suppressing ER stress–ATF6–GSDMD-mediated #Pyroptosis and protecting retinal ganglion cells. #STTT #OpenAccess: doi.org/10.1038/s413... #RetinalResearch #Neuroscience

Ambient light alleviates retinal neurodegeneration in mice by powering mitochondria via the engineered optoenergetic rhodopsin

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