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Reposted by @sidoniaf.bsky.social

Thiago Carvalho @cyrilpedia.bsky.social · 15/12/2025

This #Preprint reports that B6 (but not wild mice) have a truncated PDL2, missing an active intracellular signalling domain: "Surprisingly, in C57BL/6J (B6) mice PD-L2 has only a 5-amino acid intracellular domain, and the same is true for several other laboratory mouse strains" #Immunology

biorxiv.org

PD-L2 Regulates Natural Antibody and IL-10 Secretion by B-1 cells

B-1 cells are innate-like lymphocytes that play a critical role in homeostasis by secreting natural antibodies, typically IgM, and immunosuppressive molecules such as IL-10. However, the regulation of...

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Reposted by @sidoniaf.bsky.social

Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · 15/12/2025

In a @cp-cell.bsky.social Benchmarks article, Masamichi Muramatsu, Sidonia Fagarasan et al tell the story of the discovery of AID in the Honjo lab, solving the decades long mystery of the molecular effector of Ig class switch recombination and somatic hypermutation. #Immunology

cell.com

Activation-induced cytidine deaminase: The missing piece of many puzzles

Twenty-five years ago, two Cell papers reported the key missing functional piece in three molecular puzzles. The genetic swapping of immunoglobulin constant regions, the mutational fine-tuning of anti...

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Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · 15/12/2025

In the same issue, Revy, Fischer and Durandy showed that the same gene, AID, was responsible for a mysterious form of hyper-IgM syndrome that was not linked to mutations in the CD40 pathway, demonstrating that AID also controlled CSR and SHM in humans. www.cell.com/fulltext/S00...

cell.com

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

The activation-induced cytidine deaminase (AID) gene, specifically expressed in germinal center B cells in mice, is a member of the cytidine deaminase family. We herein report mutations in the human c...

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Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · 15/12/2025

Prof Tasuku Honjo is now the Director of CCII, our new center in Kyoto University, dedicated to deciphering anti-tumor immunity and discovering the next generation of cancer immunotherapies. www.ccii.med.kyoto-u.ac.jp/en/

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Reposted by @sidoniaf.bsky.social

Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · 16/12/2025

Participants emerge from the conference room into the bright sunlight of Naoshima Island in CCII's first international symposium on Cancer, Metabolism, and Immunity. CCII sponsored this small, intimate meeting where participants freely shared and discussed ideas & data in a beautiful setting.

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