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Sid

@sidmall.bsky.social
408 followers 67 following 3 posts

Postdoc @dunnelab @QubPGJCCR @CRUKSI Computational biologist | Cancer Researcher Interest in biology underpinning cancer signalling and disease evolution. Views are my own.

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Reposted by Sid
Joshua Bull @joshuabull.bsky.social · 13/12/2024
Sounds like what we need is something that makes it easier to generate quantitative, interpretable metrics that describe observable biological differences in tissue, without being a black box and requiring unreasonable amounts of training data... www.muspan.co.uk doi.org/10.1101/2024...
doi.org
MuSpAn: A Toolbox for Multiscale Spatial Analysis
The generation of spatial data in biology has been transformed by multiplex imaging and spatial-omics technologies, such as single cell spatial transcriptomics. These approaches permit detailed mappin...
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Reposted by Sid
bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 03/12/2024
Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state www.biorxiv.org/content/10.1101/202…
biorxiv.org
Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state https://www.biorxiv.org/content/10.1101/2024.11.28.625928v1
In colorectal cancer (CRC), tumours classifier as consensus molecular subtype 4 (CMS4) have the wors
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Reposted by Sid
Philip Dunne @profpipdunne.bsky.social · 06/12/2024
Massive congrats to Shania, Svetlana & Noha (not on Bsky) identifying the mechanistic and phenotype cascades underpinning the anti-metastatic response triggered by viral mimicry TLDR; aggressive CMS4 tumours can be reprogrammed towards less aggressive CMS1 biorxiv.org/content/10.1... thread 👇
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Philip Dunne @profpipdunne.bsky.social · 04/12/2024
Massive congrats Courtney and @sidmall.bsky.social on their dualGSEA publication nature.com/articles/s41... dualGSEA blends pair-wise and single sample GSEA approaches alongside a range of visual outputs, making biological interpretation of results much easier. 👀🧵👇& then Repost please!
nature.com
Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data - Scientific Reports
Scientific Reports - Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data
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Reposted by Sid
Fabian Theis @fabiantheis.bsky.social · 20/11/2024
1/ 🧬 Single-cell genomics reveals biological variations beyond cell types. Unveiling these in separate latent dim’s is known as disentanglement. Led by @AmirAliMoinfar, we develop DRVI to learn nonlinear, disentangled & interpretable latent spaces. biorxiv.org/content/10.1101/2024.11.06.622266v1
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Reposted by Sid
Itai Yanai @itaiyanai.bsky.social · 19/11/2024
We ask students to write a research proposal, but we should also teach them about how the project will likely actually unfold.
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Sid @sidmall.bsky.social · 18/11/2024
Hello, could I be added too, please. Thanks!
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Sid @sidmall.bsky.social · 16/11/2024
Hello 👋, I would be keen to join too, please. Thank you!
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Sid @sidmall.bsky.social · 16/11/2024
Hello, would love to be included as well, please! Thank you.
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