SHARE CTD @sharectd.bsky.social · 25/09/2026We can't wait to meet you in Berlin! ✈️ #ScienceSky #AcademicSky #ClinicalTrials #DataSharing #OpenScience #SHARECTD #HorizonEurope #ResearchIntegrity 000
SHARE CTD @sharectd.bsky.social · 25/09/2026Join us! 🗓️ Abstract Submission Deadline: 28 February 2027 📩 Notification of Outcome: 30 April 2027 Key topics: • Clinical trial data sharing policies & regulation • FAIR data, metadata standards & privacy • Reproducibility, re-analysis & research integrity • Patient engagement & societal impact 101
SHARE CTD @sharectd.bsky.social · 25/09/2026✨ Day 2: From Shared Data to Better Evidence & Better Outcomes (Reproducibility, Methodological Innovation & Impact) We welcome posters & talks on everything from FAIR data, IPD meta-analysis, privacy, and governance to patient trust! 🧵👇 100
SHARE CTD @sharectd.bsky.social · 25/09/2026Over 2 days, we’re bringing together researchers, policymakers, regulators, journal editors, and patient advocates to shape the future of clinical trial data sharing: ✨ Day 1: Enabling Clinical Trial Data Sharing (Governance, FAIRification, Anonymization, Infrastructures & Workshops) 100
SHARE CTD @sharectd.bsky.social · 25/09/2026Join us in Berlin for: "The Future of Clinical Trial Data Sharing: Re-use, Reproducibility and Impact" 📅 13–14 September 2027 🏢 Kaiserin-Friedrich-Haus, Berlin 🌐 Details & Call for Abstracts: www.share-ctd.eu/final-confer... 100
SHARE CTD @sharectd.bsky.social · 25/09/2026📍 SAVE THE DATE & CALL FOR CONTRIBUTIONS! 📍 The SHARE-CTD Final Conference is officially happening! 111
SHARE CTD @sharectd.bsky.social · 16/06/2026Incredible work! This is a major contribution to making science more self-correcting and transparent. Read the full article here: 👉 doi.org/10.1001/jama... #ScienceSky #AcademicSky #ResearchIntegrity #ClinicalTrials #OpenScience #EvidenceBasedMedicinedoi.orgRetracted Randomized Clinical Trials From Authors With Multiple RetractionsThis cohort study evaluates the author and publication characteristics of retracted randomized clinical trials. 010
SHARE CTD @sharectd.bsky.social · 16/06/2026For those working on data reuse and trial transparency, this paper provides crucial context on: 🚩 The characteristics of trials that end up retracted. 🚩 The impact of "top-cited" status on research accountability. 🚩 The systemic nature of retractions in our field. 110
SHARE CTD @sharectd.bsky.social · 16/06/2026The paper takes a hard look at the patterns behind retracted RCTs, focusing on "superretractors" and highly-cited scientists. In the world of #ClinicalTrials, understanding why and how evidence fails is just as important as the evidence itself. 100
SHARE CTD @sharectd.bsky.social · 16/06/2026Huge congratulations to our fellow researcher @minoo-matbouriahi.bsky.social on her latest publication in JAMA Network Open! She teamed up with @floriannaudet.bsky.social John Ioannidis @ioanaacristea.bsky.social, and a stellar team to tackle a fascinating topic in #ResearchIntegrity #PeerOnSky 121
Reposted by SHARE CTDFlorian Naudet @floriannaudet.bsky.social · 06/05/2026- Green: ResToRes : Cédric Lemarchand - Orange : OSIRIS : @constantvinatier.bsky.social - Purple : @sharectd.bsky.social : @giulia-varvar.bsky.social and @kahin-tai.bsky.social - Red : Former member of the team, now in iRISE_EU : Laura Caquelin ... and me ;) 031
SHARE CTD @sharectd.bsky.social · 14/04/2026Huge congrats to all the doctoral students and supervisors involved! This is a step forward for transparency in clinical research. @cburgwinkel.bsky.social @jifanw.bsky.social @kahin-tai.bsky.social @heldleonhard.bsky.social 🎉 Check out the paper here: 🔗 link.springer.com/article/10.1...link.springer.comSupporting reanalysis and reuse of clinical trial data: a case study - TrialsBackground Reproducing published findings from clinical trials is a critical component of scientific transparency, yet it remains a challenging and under-practiced task. Despite increasing emphasis on... 011
SHARE CTD @sharectd.bsky.social · 14/04/2026Reproducibility isn't just a buzzword. Our case study highlights: 1. The immense value of systematic reproducibility checks. 2. The urgent need for researchers to fix reporting gaps. 3. Why "Data Sharing" must be more than just a checkbox—it needs to be functional. 110
SHARE CTD @sharectd.bsky.social · 14/04/2026The good news? The original conclusions of the oncology trial were confirmed. The "real" news? The path to getting there was bumpy. We encountered: 🚩 Incomplete protocols 🚩 Broken links in documentation 🚩 Data sharing hurdles that slowed down the reproduction process. 110
SHARE CTD @sharectd.bsky.social · 14/04/2026In July 2025, 11 PhD students, divided into 5 teams, took on a challenge: Reproduce a large-scale clinical trial on oncology. Supervised by Prof. Dr. Ulrich Mansmann, Prof. Dr. Ulrich Sax, and Prof. Dr. Leonhard Held, we went deep into the raw data to see if the original conclusions held up. 110
SHARE CTD @sharectd.bsky.social · 14/04/2026Big news! 🚀 We are thrilled to announce that our first joint publication by 11 SHARE-CTD doctoral students is officially out in @springernature.com "Supporting the Reanalysis and Reuse of Clinical Trial Data: a case study" This paper is the fruit of our very first Datathon in Göttingen. 🧵 112
Reposted by SHARE CTDFlorian Naudet @floriannaudet.bsky.social · 14/02/2026Yesterday was the last day of our @sharectd.bsky.social Datathon 2 in Utrecth. Over the 1 week, 3 independent teams worked on the same research question: “Does esketamine have an impact on suicidality?”, using the same individual patient data shared by Johnson & Johnson on the The YODA repository. 196
SHARE CTD @sharectd.bsky.social · 13/02/2026In a traditional RCT, we recruit an intervention group and a control group simultaneously. In External Controlled Trials, the control group is sourced externally from: 1️⃣ Real-World Data / Electronic Health Records. 2️⃣ Data from previous clinical trials (Historical Controls). 3️⃣ Patient registries. 000
SHARE CTD @sharectd.bsky.social · 13/02/2026Why skip the internal control? ✅ Ethical Concerns: In rare or terminal diseases, giving a placebo can be unethical if an intervention shows early promise. ✅ Feasibility: nearly impossible to find data in an extremely small population. ✅ Efficiency: speed up the development of life-saving therapies 000
SHARE CTD @sharectd.bsky.social · 13/02/2026Beware of BIAS = our biggest enemy! Since there’s no randomisation, we face "Confounding by Time." Is the patient doing better because of the new drug, or because the "Standard of Care" in 2026 is better than the historical data from 2015? 000
SHARE CTD @sharectd.bsky.social · 13/02/2026The takeaways: 1. ECT requires even more rigorous data cleaning. 2. Data Quality is King: Garbage in, garbage out. If your external source is messy, your trial is invalid. 3. Regulatory Alignment: Always consult with FDA/EMA/local regulators early if you plan to use an ECT for drug registration. 010
SHARE CTD @sharectd.bsky.social · 13/02/2026The world of clinical trials is evolving from rigid to "Pragmatic & Adaptive." ECT proves that past data can save future lives. Have you ever worked with External Controls or Synthetic Arms? Let’s discuss below! 👇 #PeerOnSky #ClinicalTrials #ExternalControlledTrials #RealWorldEvidence 000
SHARE CTD @sharectd.bsky.social · 13/02/2026Hi #ScienceSky people, back with #PeerOnSky series! After discussing reporting bias, let’s dive into a topic that’s currently reshaping regulatory landscapes and drug development: External Controlled Trials (ECT). Ever heard of "Synthetic Controls" or "Historical Controls"? Let’s break it down! 500
Reposted by SHARE CTDFlorian Naudet @floriannaudet.bsky.social · 31/12/2025This paper is fully aligned with the themes of our @sharectd.bsky.social doctoral network featuring stellar PhD students (such as @kahin-tai.bsky.social and @giulia-varvar.bsky.social with whom we have published several nice papers on data sharing). a) www.jclinepi.com/article/S089...jclinepi.comReusing clinical trial data to consolidate and advance medical knowledgeWhile data sharing holds great potential to maximize the value of research and reduce waste, these benefits can only be fully realized if shared data are also effectively reused. Yet, data reuse remai... 131
Reposted by SHARE CTDFlorian Naudet @floriannaudet.bsky.social · 10/01/2026@kahin-tai.bsky.social's excellent talk (delivered as part of the LORIER Webinar Series on Reproducibility and Meta-Research, in partnership with @sharectd.bsky.social, ResToRes Research integrity in biomedical research, OSIRIS, the @reproductible-fr.bsky.social and Embrace) is now online. 123
Reposted by SHARE CTDFlorian Naudet @floriannaudet.bsky.social · 08/02/2026Over the coming days, three independent teams (@sharectd.bsky.social PhD students + clinical & statistical experts) will each conduct their own IPD meta-analysis to answer the same research question. 👉 Can esketamine reduce suicidality? 113
Reposted by SHARE CTDFlorian Naudet @floriannaudet.bsky.social · 08/02/2026Stay tuned... I’ll share updates during the week. And @sharectd.bsky.social website is here : www.sharectd.eusharectd.euNEWSAttendance at the EMA Biostatistics Special Interest Area Journal Club 2026.01.21 Prof. Dr. Martin Posch (MUW) will present on February 18, 2026 at th… 121
SHARE CTD @sharectd.bsky.social · 28/01/2026How do we fix this? ✅ Preregistration is King: Stick to your original protocol. ✅ SAP Transparency: Publish your Statistical Analysis Plan before unblinding. ✅ Report Everything: If it was a primary outcome in your protocol, it MUST be in your paper, regardless of the p-value. 000
SHARE CTD @sharectd.bsky.social · 28/01/2026The message for us is clear: Negative results are not "failed" results. When we delete non-significant data, we: 1. Distort systematic reviews/meta-analyses. 2. Waste resources on "new" studies that have actually failed before. 3. Betray the trust of the participants who volunteered. 100
SHARE CTD @sharectd.bsky.social · 28/01/2026But here's the kicker: The omission was significantly more likely if the results were not statistically significant (p > 0.05) 000
SHARE CTD @sharectd.bsky.social · 28/01/2026The interviews revealed that the reasons aren't always malicious. It's often: the "it's not interesting" excuse; lack of clinical importance (as perceived by the author); inconsistency between the protocol and the final analysis. 100
SHARE CTD @sharectd.bsky.social · 28/01/2026Smyth (2010) interviewed trialists and found a troubling pattern. ORB isn't just a myth; it's a systematic issue where researchers tend to report "good" results while burying non-significant ones. The study found that about one-third of trials had at least one primary outcome changed or omitted. 🚩 000
SHARE CTD @sharectd.bsky.social · 28/01/2026Long time no see, #ScienceSky people! 👋 After a short hiatus, we're reliving the #PeerOnSky series. A "silent" issue in clinical trials: Outcome Reporting Bias (ORB). Let's revisit a classic but vital paper by Smyth et al. (2010) that gets into the heads of trialists. www.bmj.com/content/342/...bmj.comFrequency and reasons for outcome reporting bias in clinical trials: interviews with trialistsObjectives To provide information on the frequency and reasons for outcome reporting bias in clinical trials. Design Trial protocols were compared with subsequent publication(s) to identify any discr... 320
SHARE CTD @sharectd.bsky.social · 30/09/2025#PeerOnSky Article 2! "Meta-analysis of individual participant data: rationale, conduct, and reporting" by Riley et al. (2010). IPD boosts power for subgroups and adjusts for confounders. Read: doi.org/10.1136/bmj.... What challenges do you face in IPD meta-analyses? #OpenScience #MetaAnalysisdoi.orgMeta-analysis of individual participant data: rationale, conduct, and reportingThe use of individual participant data instead of aggregate data in meta-analyses has many potential advantages, both statistically and clinically. Richard D Riley and colleagues describe the rational... 010
SHARE CTD @sharectd.bsky.social · 18/08/2025🔬 #PeerOnSky starts! “Clinical Trial Participants’ Views of the Risks and Benefits of Data Sharing” by Mello et al. (2018). They found participants value data sharing for science, but worry about privacy breaches. A 2018 perspective still relevant today! Does this reflect current views? #DataEthics 031
SHARE CTD @sharectd.bsky.social · 18/08/2025🎉 Hello all! Welcome to #PeerOnSky! It stands as 'Peer discussion on the Sky'. We will dive into cutting-edge research, sparking discussion on BlueSky using the articles discussed within our network. We’ll kick off with a 2018 gem on clinical trial data sharing. #OpenScience #Research #JournalClub 030
SHARE CTD @sharectd.bsky.social · 18/07/2025We worked heavily on coding and biostats exercises, and balanced it out with 'rainy' BBQ evening, City tours, and German/Italian feasts. Datathon1 had it all! 😍Big thanks to the organisers and all participants! #hackathon #OpenScience #ClinicalResearch #biostatistics 051
SHARE CTD @sharectd.bsky.social · 18/07/2025🌧️ Just wrapped Datathon1 at UMC Göttingen, from 07 to 11 July! Part of SHARE-CTD, this in-person event brought doctoral students, PIs, and lecturers together for clinical trials, biostats, and data mgmt. Check the Vibes! #SHARECTD #Datathon #Research #biostatistics 151
SHARE CTD @sharectd.bsky.social · 02/06/2025The paper @mrcctu.bsky.social offers 8 principles: proactively share results, give participants a choice, make it timely & accessible, involve patients in planning, and more. It’s a call to honor participants’ roles in research. So important for trust! #PatientVoice #OpenScience What do you think? 020
SHARE CTD @sharectd.bsky.social · 02/06/2025💬 Participants deserve to know! This Trials paper (doi.org/10.1186/s130...) pushes for sharing clinical trial results with participants—because their contributions matter. From a patient’s view, it’s about respect & transparency. Let’s dive in! #ClinicalTrials #Transparency #ShareCTDdoi.orgSharing clinical trial results with participants: important, expected and possible - TrialsParticipants in clinical trials should be pro-actively offered the results of trials in which they have participated. This should be done in a way that is accessible and understandable for all partici... 260
SHARE CTD @sharectd.bsky.social · 30/05/2025We are optimistic about this momentum! What do you think—can these 6 steps transform data sharing in Germany or globally? Share your views or tag a colleague. @sharectd.bsky.social is here to discuss! #ResearchEthics #OpenAccess #ShareCTD #DataSharing 020
SHARE CTD @sharectd.bsky.social · 30/05/2025The paper highlights barriers: low sharing rates, GDPR uncertainty, & researcher liability. Solutions include integrating data sharing in ethics applications, mainstreaming consent, & creating data clearing offices. A step toward patient benefit! #ClinicalResearch #Transparency 020
SHARE CTD @sharectd.bsky.social · 30/05/2025🔬 New paper alert! BMC study (doi.org/10.1186/s128...) proposes 6 solutions target ethics, registries, & governance to tackles Germany’s clinical data sharing crisis. Only 2% of medical research shares data—time for change! Read on! #OpenScience #DataSharing #ShareCTD 250
SHARE CTD @sharectd.bsky.social · 21/05/2025What's your take on this, guys? @cburgwinkel.bsky.social @giulia-varvar.bsky.social @minoo-matbouriahi.bsky.social @obinwanne.bsky.social @gregpapapostolou.bsky.social 011
SHARE CTD @sharectd.bsky.social · 21/05/2025Huge thanks for the shoutout, @floriannaudet.bsky.social ! 📊 This Nature paper on anonymization in biomedical research is spot-on for our mission at SHARE-CTD. Balancing data sharing with privacy is key—any thoughts on best practices? @kahin-tai.bsky.social @jifanw.bsky.social @yazidoxx.bsky.social 022
SHARE CTD @sharectd.bsky.social · 21/05/2025We enjoyed it too, participating online though. Kudos to the committe and all participants! 000
SHARE CTD @sharectd.bsky.social · 21/05/2025The study highlights how widely shared datasets like NHANES can be exploited. It is urging better oversight and that trust in data-sharing is key! What safeguards do you think we need? Drop your thoughts below or tag a colleague @plosbiology.org keen to hear your take! #SHARECTD #OpenData #Integrity 010
SHARE CTD @sharectd.bsky.social · 21/05/2025🔍 Fascinating read! This PLOS Biology paper uncovers misuse of the NHANES dataset by potential paper mills—raising red flags on shared data integrity. Not about trials, but a must-discuss for research ethics. Check it: journals.plos.org/plosbiology/... #ResearchEthics #DataIntegrity #OpenSciencejournals.plos.orgExplosion of formulaic research articles, including inappropriate study designs and false discoveries, based on the NHANES US national health databaseThe combination of AI and national health databases offers opportunities, but may also be exploited by unethical agents. This study shows that there has been an explosion of formulaic research article... 162