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Shaili Mathur

@shaili-mathur.bsky.social
18 followers 15 following 0 posts

Biology PhD student @ Stanford w. Dmitri Petrov and Jonas Cremer

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Reposted by Shaili Mathur
Mark Bitter @markcbitter.bsky.social · 12h
New Perspective w/ @petrovadmitri.bsky.social and Paul Schmidt! We ask what evolution-in-action studies tell us about an old question: what genetic variation matters for fitness, and what maintains it? ecoevorxiv.org/repository/v...
ecoevorxiv.org
Common, consequential, and actively maintained: a neo-balance view of genetic variation
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Reposted by Shaili Mathur
Sasha (Alexandra) Khristich @khristich.bsky.social · 22/09/2026
I’m excited to share our preprint with @oliviamghosh.bsky.social, where we explore what it takes to ‘win’ in long-term evolutionary competition: www.biorxiv.org/content/10.1...
biorxiv.org
Adaptive evolution can overwrite initial natural fitness variation only in highest-fitness yeast isolates
The fitness of an organism determines its likelihood of succeeding in short-term competition, but many other factors can influence its long-term success. In this study, we investigate the relative con...
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Reposted by Shaili Mathur
José Aguilar-Rodríguez @jaguilarrod.bsky.social · 22/10/2025
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential. www.biorxiv.org/content/10.1...
biorxiv.org
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
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