Increased understanding of the functional complexity of the genome has led to growing recognition of the role of non-sequence-based regulatory variation in disorders of the human central nervous syste...

The unfolded protein response (UPR) is a fundamental stress pathway coopted in cancer, and it is thought to drive adaptation, tumor progression, and therapeutic resistance. While the analysis of ‘sing...

Introduction Evidence-based dosing guidance for medications in critically ill patients with acute kidney injury (AKI) and receiving continuous kidney replacement therapy (CKRT) is limited. Freely av.....

npj Quantum Information - Practical blueprint for low-depth photonic quantum computing with quantum dots

Lipid nanoparticles are improved by including RNA cargo size in the design process.

Windowing is the process in which the pixel values of an image are remapped to enhance the contrast of the regions of interest. For example, the width and level of the contrast window are adjusted to ...

Based on single-cell data from a cohort of 584 brain donors including patients with Alzheimer’s disease (AD) and controls, a graph neural network is used to investigate differential patterns between d...

AbstractMotivation. Groups of complex diseases, such as coronary heart disease, neuropsychiatric disorders, and cancers, often display overlapping clinical

Visual field testing is essential for detecting glaucomatous damage. Traditional approaches such as pointwise linear regression often fail to account for the spatial correlations and hierarchical stru...

At the AI as Catalyst meeting in Manaus (July 28–29, 2026; https://ia-como-catalisadora-manaus.netlify.app), participants ran a simple exercise. Working in teams, they wrote about ten clinical cases a...

Background Conflicting evidence from observational studies and randomised trials has created uncertainty about the association between attention-deficit/hyperactivity disorder (ADHD) medication use an...

In the United States, the New Technology Add-On Payment (NTAP) program incentivizes the development and adoption of novel clinical technologies by providing supplemental Medicare reimbursement for ...

Background Genome annotation is an important step in deriving functional meaning from prokaryotic sequencing data, yet systematic evaluations guiding tool selection are lacking. We present the first l...

Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Long COVID (LC19), post-traumatic stress disorder (PTSD), rheumatoid arthritis (RA), and multiple sclerosis (MS) are clinically ...

Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudi...

Human papillomavirus (HPV) accounts for 5–10% of all cancers globally, with approximately 630,000 new cases annually [1]. HPV is a key etiologic factor in head and neck cancers (HNCs), particularly in...

Multidomain proteins connected by flexible linkers populate conformational ensembles that are challenging to characterize using conventional structural biology methods. In domain–linker–domain (DLD) p...

Artificial intelligence has significantly expanded candidate generation in drug discovery, but selecting optimal compounds under real-world experimental constraints remains a major bottleneck. This re...

The sixth modeling workshop (6MW) was held in June 2025 at Collegeville, Pennsylvania, USA, and supported by the Recovery of Biological Products Conference Series. The goal of the workshop was to ass...

Promising trial results suggest cancer vaccines work and could be used to target other tumours.

Abstract. Two-dimensional transition metal dichalcogenide (TMD) interfaces offer a versatile platform for studying quantum phenomena and developing device

Author summary Type 2 diabetes is a major global health concern, often leading to serious complications such as heart disease, stroke, and kidney failure. Identifying individuals at high risk of devel...

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Artificial intelligence (AI)-based prediction models, including risk scoring systems and decision support systems, are being increasingly adopted in health care. Addressing AI fairness is essential to...

Abstract. A long-standing goal in computational chemistry and materials science has been the development of general-purpose interatomic force fields that d

Many important biological functions arise not from single genes but from complex interactions encoded by entire genomes. We report the first generative design of complete bacteriophage genomes using g...

Syncope is a common clinical problem caused by transient cerebral hypoperfusion and encompasses reflex, orthostatic, and cardiac mechanisms. Accurate diagnosis relies on careful history taking and ...

Scientific Data - Near telomere-to-telomere genome assembly of the rainbow trout (Oncorhynchus mykiss)

A computational de novo design framework enables the design of α-helical peptides that assemble into transmembrane barrel-stave pores (TBPs). Here, TBPs are designed for antimicrobial activity, with b...

While AI coding tools have demonstrated potential to accelerate software development, their use in scientific computing raises critical questions about code quality and scientific validity. In this pa...

Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo d...

This Perspective highlights key research areas within mass spectrometry-based proteomics where AI is poised to drive significant advances.

Gedman, Morril-Pirovich, et al. reconstruct the most complete and high-coverage dire wolf genome to date from ancient DNA using iterative and pangenome approaches. The authors find evidence supporting...

Caffeine is one of the most commonly consumed drugs in the world. It is found in various naturally occurring substances and can be ingested in a synthetically derived pure form. The majority of human ...

The CEDAR Embeddable Editor overlays broadly-accepted discipline-specific metadata templates on top of Dryad’s default FAIR metadata schema, maintained by DataCite.

AbstractObjectives. This study explores the use of advanced natural language processing (NLP) techniques to enhance food classification and dietary analysi

Macedo et al. report the longitudinal spatiotemporal dynamics of tau from positron emission tomography. They find distinct dynamics in tau extent and load across Alzheimer’s disease stages, highlighti...

In this Review, the authors discuss the advantages, limitations and applications of spatial omics technologies in kidney research. They also discuss novel imaging methods that may extend 2D spatial an...

Phononic integrated circuits enable scalable control of acoustic waves but lack efficient traveling-wave amplifiers. Here, authors demonstrate a GaN-on-sapphire Brillouin-based unidirectional travelin...