iiinova — where your digital self keeps evolving

Seth Bannon @sethbannon.bsky.social · 04/10/2025

The non-monarchies that put their sitting leaders on money: Iraq Syria Turkmenistan Ghana Uganda Libya Turkey Kenya Tanzania Malawi Zambia Guinea Dominican Republic Bangladesh Vietnam Indonesia Botswana Tunisia North Vietnam

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Seth Bannon @sethbannon.bsky.social · 13/07/2025

The best and the brightest from around the world studying at American universities is great for America. Our universities are magnets for the world's top talent. They draw them into America, where they often stay, build incredible companies, open great labs, become Americans!

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Seth Bannon @sethbannon.bsky.social · 15/06/2025

When you create a maximally truth seeking AI and it conflicts with your worldview, you can do one of two things...

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Seth Bannon @sethbannon.bsky.social · 11/06/2025

Ambition without mission is a sprint to nowhere.

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Seth Bannon @sethbannon.bsky.social · 07/06/2025

IT'S TIME TO BUILD Big things. Bold things. Like replacing your local car dealership’s receptionist with ChatGPT apparently.

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Reposted by Seth Bannon

Bjorn Fraser Olaisen @bjornolaisen.bsky.social · 01/06/2025

No program or course has given me more transformative insights into #company building and personal development than the 5050 UK program (www.fiftyyears.com). Each week, the @FiftyYears team mentors us on how to develop the traits of great founders… Thread. www.linkedin.com/posts/bjorno...

fiftyyears.com

Fifty Years

Fifty Years – We back the indispensable using technology to solve the world's biggest problems.

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Seth Bannon @sethbannon.bsky.social · 02/06/2025

The best possible future is one in which the US and China build the future together as allies.

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Seth Bannon @sethbannon.bsky.social · 01/06/2025

Convening a dozen federal agencies. To tackle healthcare? AI policy? Economic growth? No. To go after Harvard.

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Seth Bannon @sethbannon.bsky.social · 29/05/2025

80% of Chinese STEM grads stay in the US. They build American companies, advance American science, power the American economy. The ones that go back home PAID to be influenced by America. They often return with a love of the USA and a deep connection to America.

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Seth Bannon @sethbannon.bsky.social · 27/05/2025

Harvard’s refusal to bow to authoritarian pressure is goddamn impressive.

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Seth Bannon @sethbannon.bsky.social · 23/05/2025

A great strength of America is that the best and brightest from around the world clamor to come here. To innovate and build on our shores. Why are we fighting to change that?

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Seth Bannon @sethbannon.bsky.social · 11/05/2025

Israel and the United States causing and allowing the mass starvation of women and children will only radicalize another generation. It's the surest way to prolong the cycle of violence. It makes Israel less safe and is unfathomably cruel to the people of Gaza.

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Seth Bannon @sethbannon.bsky.social · 09/05/2025

It’s fair to ask why everyone in the US gets due process before deportation, including those here illegally. The answer is simple: without due process for everyone, the government could deport citizens, because due process is how citizens prove they are citizens.

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Seth Bannon @sethbannon.bsky.social · 25/04/2025

Metformin might be the most studied longevity drug that’s already FDA approved. Improves insulin sensitivity, fitness, and immune function in healthy adults. elicit.com/review/22d92...

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Seth Bannon @sethbannon.bsky.social · 22/04/2025

The great strength of America is that it attracts the best and the brightest from around the world. For the first time in modern history, America is facing a brain drain. This is how you give up the future. www.nature.com/articles/d41...

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Seth Bannon @sethbannon.bsky.social · 14/04/2025

If you wanted to absolutely gut American manufacturing capabilities, you would tax manufacturing inputs to drive up the cost of manufacturing things in the US, while taxing imported finished products at a lower rate, to advantage companies that manufacture overseas.

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Seth Bannon @sethbannon.bsky.social · 11/04/2025

None of those are reasons we need to test in animals. They're reasons we needed to test in animals. We're on the cusp of having better modeling and non-animal systems to get this data.

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Seth Bannon @sethbannon.bsky.social · 10/04/2025

9/ We’re entering an era where the slowest part of medicine won’t be the science -- it’ll be the willingness of institutions to evolve. Good to see the FDA modernizing like this!

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Seth Bannon @sethbannon.bsky.social · 10/04/2025

8/ The old dogma: “We have to test it in animals.” The new ethos: “We should test it in systems that work.” That means leveraging AI, synthetic biology, and human-relevant models.

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Seth Bannon @sethbannon.bsky.social · 10/04/2025

7/ The downstream effect? 💊 Cheaper drugs 🐭 Fewer animals used ⚡️ Faster approvals 🧠 More accurate models of human biology

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Seth Bannon @sethbannon.bsky.social · 10/04/2025

6/ This isn’t just a policy update. It’s a signal. The regulatory state is catching up to the science. And that opens the door to faster, safer, and more ethical drug development.

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Seth Bannon @sethbannon.bsky.social · 10/04/2025

5/ The FDA just released new draft guidance: 🧪 Removing routine animal tests for mAbs targeting non-human antigens 🧠 Encouraging case-by-case waivers for other biologics 👀 Eyeing “stepwise” expansion of non-animal approaches

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Seth Bannon @sethbannon.bsky.social · 10/04/2025

4/ The focus now is monoclonal antibodies (mAbs), the engine behind many of the most important therapies in cancer, autoimmune disease, and infectious disease.

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Seth Bannon @sethbannon.bsky.social · 10/04/2025

3/ This shift stems from the 2022 FDA Modernization Act, which for the first time allows non-animal alternatives like computational models, organ-on-a-chip systems, and advanced in vitro assays.

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Seth Bannon @sethbannon.bsky.social · 10/04/2025

2/ For decades, animal testing has been a regulatory bottleneck in drug development. Not always predictive. Not always necessary. Very expensive. Often cruel. We have better tools now. The FDA is now acknowledging that.

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Seth Bannon @sethbannon.bsky.social · 10/04/2025

1/ GOODBYE ANIMAL TESTING Big news from the FDA: They're starting to phase out animal testing requirements for monoclonal antibodies and other biologics. HUGE DEAL for science, ethics, and innovation.

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Seth Bannon @sethbannon.bsky.social · 10/04/2025

So much potential is lost to shallow but lucrative pursuits.

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Seth Bannon @sethbannon.bsky.social · 07/04/2025

So next time you hear "trade deficit," don't picture a country getting scammed. Picture a wealthy nation swiping its card because it can.

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Seth Bannon @sethbannon.bsky.social · 07/04/2025

Yes, trade deficits can come with downsides. Losing certain industries or over-relying on imports can lead to weakness. But the deficit itself? It’s not a scoreboard. It’s a side effect of being the customer everyone wants.

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Seth Bannon @sethbannon.bsky.social · 07/04/2025

The U.S. sends dollars abroad. Other countries send back cars, electronics, clothing, steel, and other things we want. They work. We consume. That’s not “losing.” That’s power.

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Seth Bannon @sethbannon.bsky.social · 07/04/2025

Rich countries run trade deficits for the same reason rich people shop more than they sell things on Craigslist. They have money. They want stuff. And other people want their money.

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Seth Bannon @sethbannon.bsky.social · 07/04/2025

A trade deficit means your country buys more from others than it sells. That might sound bad, until you realize what it really means: you can afford it.

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Seth Bannon @sethbannon.bsky.social · 07/04/2025

A trade deficit doesn't mean your country is being screwed. It means your country is rich.

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Seth Bannon @sethbannon.bsky.social · 05/04/2025

"Walt, that's crazy." Everyone was against building Disneyland -- Walt’s finance team, his cofounder brother, his employees, even his wife! But Walt had the vision and moral authority of a founder and pushed it through. Last year, Disney Parks brought in $34B. $9B in profit.

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Seth Bannon @sethbannon.bsky.social · 04/04/2025

Deep tech is the closest thing we have to magic.

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Seth Bannon @sethbannon.bsky.social · 03/04/2025

Sure the markets are way down but at least there's a measles outbreak.

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Seth Bannon @sethbannon.bsky.social · 03/04/2025

We sent this email to all Fifty Years portfolio founders 2 weeks ago. Subject "Farewell, stability".

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Seth Bannon @sethbannon.bsky.social · 02/04/2025

Me too. And how many aren't coming now due to the administration cracking down on speech they don't like?

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Seth Bannon @sethbannon.bsky.social · 02/04/2025

21 biotech startups. Nobel Prize. AI for protein design breakthroughs. The US was building the future. Then it defunded the science behind it. World-class self-own. www.geekwire.com/2025/from-no...

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Seth Bannon @sethbannon.bsky.social · 01/04/2025

New head of the FDA 🤦 en.wikipedia.org/wiki/Marty_M...

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Seth Bannon @sethbannon.bsky.social · 30/03/2025

Getting a lot of questions about our billboard outside SpaceX. Great engineers want to build. They don't want drama and social media impacting their work. In 10 years in venture, we've never seen more SpaceX and Tesla engineers leaving to start companies.

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Seth Bannon @sethbannon.bsky.social · 26/03/2025

New billboard dropped in Hawthorne.

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Reposted by Seth Bannon

Lora Kolodny @lorak.bsky.social · 26/03/2025

who did this 👀

a billboard outside a spacex facility that says “[no] politics, drama, tweets” on one side & “just build” on the other with the url “50y.com” below that message. (50y is an early stage venture fund that invests in scientific research & deep tech startups)

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