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Sergio Serrano-Villar

@serranovillar.bsky.social
559 followers 117 following 47 posts

Physician-Scientist. Hospital Ramón y Cajal, Madrid, formerly @UCSF San Francisco. Research in HIV, microbiome, and cancer.

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Reposted by Sergio Serrano-Villar
Francisco M. Azcárate @fmazcarate.bsky.social · 15/08/2025
¿Por qué la región entre Zamora, León y Ourense arde tanto? No, no es para construir aerogeneradores, ni por ninguna de las teorías conspiranoicas que estamos leyendo. La explicación es más compleja… y menos cómoda para quienes buscan respuestas simples. 1/13
Copernicus
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Sergio Serrano-Villar @serranovillar.bsky.social · 07/03/2026
🧵 1/8 🧪 TB research has long focused on a single pathogen: Mycobacterium tuberculosis. 🦠 But TB unfolds within a complex microbial ecosystem. The human microbiome may influence susceptibility, inflammation, and treatment outcomes. Our perspective ⬇️ 🔗 t.ly/jMK3R
t.ly
Beyond bacilli: integrating the microbiome into the TB research agenda
Tuberculosis (TB) remains a leading infectious killer, with growing evidence that the human microbiome—particularly in the gut and lungs—shapes susceptibility, progression, and treatment outcomes. ...
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MicrobiomaHub-CSIC @microbiomacsic.bsky.social · 05/02/2026
Conexión MICROBIOMA presenta la infografía “Entender los test de microbioma: alcance y límites actuales”, un recurso divulgativo que explica qué analizan estas pruebas, cómo funcionan y sus limitaciones científicas y clínicas, recordando que no son diagnósticas y requieren asesoramiento profesional
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Sergio Serrano-Villar @serranovillar.bsky.social · 22/10/2025
💊 Las 3 veces que he comprado antibióticos en farmacias distintas me han ofrecido probióticos para “evitar complicaciones”. 📉 No hay evidencia sólida que respalde su uso sistemático en este contexto. 💰 Es un negocio lucrativo que no debería promoverse desde entornos sanitarios 🧪
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Sergio Serrano-Villar @serranovillar.bsky.social · 14/10/2025
1/10 🧵 Proud to share results from the INSTINCT trial, published in @cidjournal.bsky.social! A randomized study addressing a key question: Does TAF have independent effects on weight and inflammation in people with HIV? Spoiler: no 🧪 doi.org/10.1093/cid/...
doi.org
Validate User
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Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM) @iib.uam.es · 12/08/2025
El @csic.es difunde la concesión de la ayuda de proyectos sinérgicos de la Comunidad de Madrid a nuestro compañero Dr. Bruno Sainz junto con el Dr. Sergio Serrano-Villar @serranovillar.bsky.social del #IRYCIS Enhorabuena a los dos grupos de investigadores👏 @dicma-csic.bsky.social
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Hannah Harris Green @whatsitlike.me · 07/08/2025
“The Trump administration is, for the first time in history, substantially intervening inside NIH to bring it under political control,” according to a senior NIH official who spoke on condition of anonymity. My latest. www.theguardian.com/us-news/2025...
theguardian.com
‘It’s really, really bad right now’: NIH scientists dismayed by Trump cuts
Researchers say scientific community is in state of whiplash and accuse president of trying to ‘destroy’ vital work
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Prof Sam Illingworth @samillingworth.com · 08/08/2025
🧠 Lithium and Alzheimer’s A new study found that lithium protects the brain. In mice, early lithium loss triggered Alzheimer’s-like damage, but a special lithium salt reversed it. 🔗 www.nature.com/articles/s41... #SciComm #Alzheimers 🧪
nature.com
Lithium deficiency and the onset of Alzheimer’s disease - Nature
Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level...
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Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM) @iib.uam.es · 25/07/2025
📣Bruno Sainz from #IIBM @csic.es receives substantial funding in the call for synergistic projects (CAM), together with @serranovillar.bsky.social -Ramón y Cajal Hospital/IRYCIS ➡️Reprogramming The Tumor Microenvironment Through Microbiome-Derived Immunomodulatory Molecules Congratulations Bruno!!👏
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Sergio Serrano-Villar @serranovillar.bsky.social · 28/07/2025
🧬 Our new paper in TMAID: Chronic Chagas disease disrupts gut microbiome metabolism. 🔻 TCA, β-oxidation & haem pathways fall 🔺 Benznidazole partly restores microbial function 💡 Biomarkers & targets for microbiota therapies 📄 doi.org/10.1016/j.tm... 🙌@infecciosasryc.bsky.social #Chagas #Microbiome🧪
doi.org
Redirecting
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Sergio Serrano-Villar @serranovillar.bsky.social · 18/07/2025
💥 #IAS2025 | #HIV Global Alert 💥 The abrupt US funding cuts are already hitting hard: 📉 Mozambique: 25% drop in ART initiations/month 📉 Johannesburg: 30% drop in testing, diagnoses & ART/year 🌍 Latin America & Caribbean: 87% of orgs lost funding
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Sergio Serrano-Villar @serranovillar.bsky.social · 17/07/2025
🧬 Gut-heart axis 2.0. 💥🦠 A gut-bacterial metabolite (imidazole propionate) doesn’t just correlate—it causes #atherosclerosis. 🔎 Mechanism: macrophage inflammasome activation via mitochondrial ROS. 🧪Pharmacologic inhibition reversed vascular inflammation in vivo. www.nature.com/articles/s41...
nature.com
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
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Sergio Serrano-Villar @serranovillar.bsky.social · 15/07/2025
🚨 A gut bacterium, Hominenteromicrobium YB328, boosts PD-1 cancer immunotherapy by activating dendritic cells & T cells. 🧬 Precision microbiome meets precision medicine. Now heading to clinical trials 🧪 🔗 www.nature.com/articles/d41... We’re tracking this closely as part of our RUMBA study.
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Sergio Serrano-Villar @serranovillar.bsky.social · 04/07/2025
Took 4,800 years and a few stubborn molars, but we finally got the first full genome from ancient Egypt. Mummies: still better preserved than most backup hard drives.🧪🧟‍♀️ 🔗 www.nature.com/articles/d41...
nature.com
First human genome from ancient Egypt sequenced from 4,800-year-old teeth
Forty years after the first effort to extract mummy DNA, researchers have finally generated a full genome sequence from an ancient Egyptian.
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Sergio Serrano-Villar @serranovillar.bsky.social · 04/07/2025
Where do academics go when they leave for industry? The top 10 destinations are all tech giants—led by Google, Amazon, Meta & Microsoft. Pharma and biotech don’t even make the list. Fascinating shift in the R&D landscape. 🧪 🔗 www.nature.com/articles/d41...
nature.com
Transparent research: can big tech learn from big pharma?
The results of technology research and development must find their way into the published literature. New models of regulation could help.
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Reposted by Sergio Serrano-Villar
Paul Sax @paulsaxmd.bsky.social · 27/06/2025
The isolated hepatitis B core antibody: HBsAg ⛔ anti-HBs ⛔ anti-HBc ✅ What does it mean, and what should you do? A mystery solved (mostly). Plus, a poll and a couple of great videos. #IDSky blogs.jwatch.org/hiv-id-obser...
blogs.jwatch.org
The Mystery of the Isolated Hepatitis B Core Antibody, Solved
(A post inspired by years of doing eConsults, an extremely common query about hepatitis B testing, and the latest BritBox series, “Core Antibody Confidential,” starring a grizzled detective with a fad...
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Sergio Serrano-Villar @serranovillar.bsky.social · 24/06/2025
💥 Big news! We’ve secured €750K for the RUMBA project through the Synergistic Projects call. We’ll decode microbiota-derived molecules to boost immunotherapy in lung cancer. The microbiome takes the stage! 🦠🫁 🧪 #microbiome #immunotherapy #lungcancer
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Jesica Abadia @jessabbey.bsky.social · 23/05/2025
Como cada año, el taller de Sergio Serrano en #XXVIIICongresoSEIMC no se puede perder. Como convertir a la IA en tu asistente de investigación? (Si no usas la IA no pasa nada. Si la usas bien puede facilitar mucho el trabajo. Pero si la usas mal, una carrera científica puede terminarse)
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Sergio Serrano-Villar @serranovillar.bsky.social · 07/06/2025
More than twenty years ago, I was making coffee ☕ at PretaManger in London and learning the ropes on my first-ever salary. Today, I came back to speak 🎤 at the IANSociety meeting on #microbiome and #HPV. 🙏 Grateful to the organizers for bringing together such a vibrant community 🌱 t.ly/S3WyZ
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Infecciosas - Hospital Ramón y Cajal @infecciosasryc.bsky.social · 02/06/2025
Dr. Jaime Altchech, jefe de servicio de Parasitología, del Hospital de Buenos Aires y uno de los referentes en investigación en enfermedad de Chagas. 👶🏽 Su experiencia en Enf. de #Chagas congénita en nuestras sesiones monográficas. ¡Gracias por la clase magistral! 👏 #NeglectedDiseases
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Paul Sax @paulsaxmd.bsky.social · 24/05/2025
If anyone is looking for a true "start" of the effective ART era for HIV, I'd vote for Jan 1996 CROI, when 24 wk data from this study were presented for the first time. Indinavir joined ritonavir (🤮) and saquinavir (😑) with full FDA approval in March. So amazing. www.natap.org/1998/drug/03...
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Infecciosas - Hospital Ramón y Cajal @infecciosasryc.bsky.social · 22/05/2025
Un año más, estrechamos lazos con nuestr@s compañer@s de Microbiológia con el clásico nudo #SEIMC2025 🤝
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Sergio Serrano-Villar @serranovillar.bsky.social · 23/05/2025
🔬 Just out in #Microbiome: our consortium’s review highlights how #metaproteomics can reveal microbial effectors—like toxins, AMR proteins & phages—that shape microbiomes across human, animal & environmental health. A #OneHealth perspective 🌍🧫 🔗 t.ly/P-PWh #MicrobialEcology
link.springer.com
Metaproteomics in the One Health framework for unraveling microbial effectors in microbiomes - Microbiome
One Health seeks to integrate and balance the health of humans, animals, and environmental systems, which are intricately linked through microbiomes. These microbial communities exchange microbes and ...
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Infecciosas - Hospital Ramón y Cajal @infecciosasryc.bsky.social · 22/05/2025
🧵No os perdáis las novedades presentadas en seimc2025.org 📍#SEIMC2025 arranca con fuerza 💪 Aquí un hilo con nuestras aportaciones 👇
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Infecciosas - Hospital Ramón y Cajal @infecciosasryc.bsky.social · 09/05/2025
Caso clínico: 👩‍⚖️ ♀ 52 años natural de El Salvador con miocardiopatía periparto. Tx ❤️marzo 24. Estudio preTx Nov 2023 con serología + Trypanosoma cruzi (no revisada).
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Infecciosas - Hospital Ramón y Cajal @infecciosasryc.bsky.social · 06/05/2025
🎓Excelente revisión sobre terapia nebulizada en pacientes hematológicos. Dr. Jesús Fortún. ✅ En nuestro ensayo aleatorizado con ANF-B nebulizada en pfx de aspergilosis Invasiva observamos reducción de inflamación pulmonar por PET. shorturl.at/R4Avq ✅ La terapia nebulizada en pfx es prometedora
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Peter Graystock @pgraystock.bsky.social · 05/05/2025
📣 Imperial College Research Fellowships! Prestigious 4yr fellowship ✔️ Salary from £48k ✔️ Up to £45k for research ✔️ A supportive, inclusive research environment ✔️ UK or international ✔️ <4 yrs post-PhD Drop me a pm if you are interested in bee/microbe related research! tinyurl.com/mr3k5a93
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Paul Sax @paulsaxmd.bsky.social · 07/01/2025
Very sensible take on Covid (and other infections) in kids for 2025.
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Paul Sax @paulsaxmd.bsky.social · 22/03/2025
Anyone who attended this year's #CROI2025 will tell you it was a very strange experience given the current political climate. Still, plenty of interesting studies -- here's a Really Rapid Review of selected highlights. #IDSky #HIVSky blogs.jwatch.org/hiv-id-obser...
blogs.jwatch.org
Really Rapid Review: CROI 2025 San Francisco
Wow, that was an interesting conference — in ways both good and bad. The good part was the content, as the Conference on Retroviruses and Opportunistic Infections (CROI) is our leading HIV research co...
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Marta González Sanz @martagonzalezsanz.bsky.social · 13/04/2025
Don't forget to come and chat to us about our poster on the diagnostic value of CT-guided biopsy for spondylodiscitis! #ESCMIDGlobal #IDSky #MedID @infecciosasryc.bsky.social
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Dr Alfonso J Rodriguez-Morales MD MSc DTM&H FACE FISAC HonDSc @drajrodriguezm.bsky.social · 02/04/2025
Great work lead by Aula Abbara and @martagonzalezsanz.bsky.social. Travel Med Infect Dis 2025 Epub Ahead Apr 2; www.sciencedirect.com/science/arti... #OneHealth #GlobalHealth #Syria #TravelMedicine #InfectiousDiseases #NeglectedTropicalDiseases #HumanitarianCrisis #ESCMID #ESGITM #ESGCP
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Marta González Sanz @martagonzalezsanz.bsky.social · 12/04/2025
Very excited to be at ESCMID Global 2025! Check out our work! #ESCMIDGlobal #MedSky #IDSky
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Marta González Sanz @martagonzalezsanz.bsky.social · 12/04/2025
Bringing the focus on Neglected Tropical Diseases: cystic echinococcosis #BeatNTDs #ESCMIDGlobal 2025 #MedSky #IDSky
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Carlos del Río, MD, FACP, FIDSA @docdelrio.bsky.social · 11/03/2025
Today at #CROI2025 we #standupforscience and talk about the benefits of HIV research
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Sébastien Poulin @sebpoule.bsky.social · 10/03/2025
PEPFAR in a nutshell #CROI2025
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El Mundo Today @elmundotoday.com · 24/01/2025
Curiosamente, un joven que no se deja manipular por nadie defiende las mismas ideas que los tres hombres más ricos del mundo.
elmundotoday.com
Curiosamente, un joven que no se deja manipular por nadie defiende las mismas ideas que los tres hombres más ricos del mundo
Curiosamente, un joven que no se deja manipular por nadie ha empezado a defender las mismas ideas que los tres hombres más ricos del mundo. El joven, llamado Serapio Domínguez y natural de Zaragoza, l...
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NEJM.org @nejm.org · 10/12/2024
On this day in 1981, a landmark paper in NEJM described four patients with evidence of immunodeficiency associated with PJP pneumonia, disseminated CMV, and Kaposi sarcoma. The disease would come to be known as HIV/AIDS. Revisit the paper: nej.md/41iekKD #MedSky #IDSky
Published on This Day in 1981.  
Pneumocystis carinii Pneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men — Evidence of a New Acquired Cellular Immunodeficiency  

An illustration showing the reproductive cycle of human immunodeficiency virus type 1 (HIV-1) and sites of action of the major classes of antiretroviral medications.  

The NEJM identity sits at the bottom.
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Sergio Serrano-Villar @serranovillar.bsky.social · 05/12/2024
📢 We're hiring! Looking for a postdoc in bioinformatics/data analysis to join our team at Ramón y Cajal University Hospital, Madrid. 🧬 Focus: microbiome, diagnostics, and advanced therapies. More info here: t.ly/QQuD2 📅 Deadline: January 31st, 2025. Please share! #job #bioinformatics #microbiome
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Sergio Serrano-Villar @serranovillar.bsky.social · 04/12/2024
Freshly landed here, my first sci-bluesky-tutorial! We just published this study in #Microbiome 📢The microbiome is a potential therapeutic target to mitigate inflammation-related complications in people with #HIV 📜Article doi.org/10.1186/s401... 📺Video abstract youtube.com/watch?v=RxZe...
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