O juiz que censurou o ICL, sobre o áudio de Nikolas para Vorcaro, é o mesmo que extinguiu a ação pelo deputado usar laudo falso da PF

A desigualdade brasileira não resulta apenas da distribuição desigual da renda produzida pelo trabalho. Ela está assentada em uma estrutura de propriedade que permite a uma pequena parcela da sociedad...

Some say there’s a global crisis of trust — but research reveals where the real problems lie.

YouTube video by Olhar Cidade

The ten eukaryotic COMMD proteins are core components of the Commander complex, with central roles in endosomal membrane trafficking and signalling. Each protein has an α-helical N-terminal (HN) domain with a C-terminal copper metabolism gene MURR1 (COMM) domain. These ten family members assemble into a heterodecameric ring composed of five specific heterodimers. In this work we have combined structural homology searches with genome-wide predicted structures to identify ancestral COMMD-like proteins that exist as single genes in Bacteria and Archaea. Although there is limited sequence similarity to the eukaryotic proteins the bacterial and archaeal COMMD-like proteins are predicted to form homomeric ring-shaped assemblies like their eukaryotic counterparts. Our biophysical studies, crystal and cryo-EM structures confirm COMMD-like proteins readily form homooligomeric rings composed of eight or ten subunits assembled from core dimeric building blocks and inter-dimer interactions that ar