Sign in

Seb Walsh

@sebwalsh.bsky.social
1.8K followers 1.8K following 108 posts

Public heath clinical academic focused on dementia and healthy ageing. Queen Mary University of London. Views own

PostsRepliesMedia
Reposted by Seb Walsh
NIHR Policy Research Unit: DeNPRU-QM @denpru-qm.bsky.social · 21/01/2026
The Nottingham Consensus provides a policy roadmap to reduce dementia risk, the UK's leading cause of death. Recommendations include: 📢 Launch a targeted public health campaign to address key modifiable risk factors 💬 Adapt communication strategies to ensure relevance across diverse communities
Graphic reads 'The Nottingham Consensus. Read the publication and policy brief: denpru-qmul.nihr.ac.uk/resources. Image of two speech bubbles and the DeNPRU-QM logo.
166
Seb Walsh @sebwalsh.bsky.social · 09/12/2025
How do we prevent as much future dementia as possible? A one-page summary of my PhD research into population-level approaches to dementia risk reduction available here: www.cph.cam.ac.uk/sites/defaul... Full thesis here: www.repository.cam.ac.uk/items/e83e56...
041
Seb Walsh @sebwalsh.bsky.social · 24/10/2025
🚨In this new systematic review in BMJ JECH, most of the 18 studies reported dynamic associations between lifecourse socioeconomic change and dementia risk. Highest risk for those born poor who stay poor. Eleanor Williams, @ilk21.bsky.social , Carol Brayne @cph.bsky.social
021
Seb Walsh @sebwalsh.bsky.social · 22/10/2025
"Interventions that reduced socioeconomic inequalities were those implemented and enforced across entire populations/systems or... were supportive and tailored to the differing needs of individuals across socioeconomic groups in their design and delivery." bmjpublichealth.bmj.com/content/3/2/...
bmjpublichealth.bmj.com
What works to reduce socioeconomic inequalities in hospitalisations and readmissions? Systematic review of the equity impacts of population-level, health service and integrative interventions
Inequalities exist in hospitalisation rates, which are undesirable and costly for health systems; with higher rates in populations with lower levels of income, education or residing in socioeconomical...
011
Reposted by Seb Walsh
Dementia Researcher @dementiaresearcher.bsky.social · 16/10/2025
Now on YouTube: Our Dementia Research Salon Livestream recording exploring #Dementia Risk Reduction - guest host Luis Tojo speaks with @sebwalsh.bsky.social, @simonesalemme.bsky.social & @timothydalyalz.bsky.social on prevention, policy & population health youtu.be/E12QCc5uWek
youtu.be
Population-level Dementia Risk Reduction
YouTube video by Dementia Researcher
033
Seb Walsh @sebwalsh.bsky.social · 14/10/2025
Increases in social media use throughout early adolescence significantly associated with [small] lower performance in specific aspects of cognitive function Social Media Use Trajectories and Cognitive Performance in Adolescents jamanetwork.com/journals/jam...
jamanetwork.com
Social Media Use Trajectories and Cognitive Performance in Adolescents
This study uses prospectively collected data from the ABCD study to assess the relationship between longitudinal patterns of social media use (hours per day) and cognitive performance after 2 years in...
010
Seb Walsh @sebwalsh.bsky.social · 23/09/2025
A privilege to represent the population health perspective, alongside Carol Brayne @cph.bsky.social , in this new @thelancet.com Series on #Alzheimer's disease. Expertly led by Giovanni Frisoni Alzheimer's disease outlook: controversies and future directions www.thelancet.com/journals/lan...
thelancet.com
Alzheimer's disease outlook: controversies and future directions
For the first time, reductions in cerebral β-amyloid pathology load and rate of cognitive and functional decline have been achieved in Alzheimer's disease, through pharmacological intervention in rand...
062
Seb Walsh @sebwalsh.bsky.social · 12/09/2025
Out of 800+ studies on blood-based biomarkers for Alzheimer's, not a single one measured actual changes in patient outcomes. doi.org/10.1136/bmj-...
doi.org
Evidence gap in blood biomarkers for Alzheimer’s disease
Willem van Gool and colleagues argue that moves to use blood biomarkers in clinical practice or population screening are inappropriate without evidence on outcomes important to patients and carers T...
021
Seb Walsh @sebwalsh.bsky.social · 10/09/2025
A key (too often ignored) aspect of Alzheimer's research is translation of findings between familial disease, specialist clinics, and general population. In this piece we identify key unanswered research questions and describe a framework for knowledge integration. www.nature.com/articles/s41...
nature.com
Key questions for the future of amyloid research in dementia: a framework for integrating complex datasets - Molecular Psychiatry
Molecular Psychiatry - Key questions for the future of amyloid research in dementia: a framework for integrating complex datasets
16919
Seb Walsh @sebwalsh.bsky.social · 08/09/2025
Nice write-up of the RETREAT-FRAIL trial from @nejm.org paper by John Mandrola in the Sensible Medicine substack www.sensible-med.com/p/evidence-t... (Paper: www.nejm.org/doi/full/10....)
sensible-med.com
Evidence, The Elderly and Common Sense
A recent trial presented at the ESC meeting addresses the question of reducing blood pressure meds in the elderly. It’s an important study—for numerous reasons.
010
Seb Walsh @sebwalsh.bsky.social · 02/09/2025
New paper with Janet Janbek using 🇩🇰 registry data to examine prevalence/co-occurrence of dementia risk factors. 82% of people >65 have multiple risk factors, speaking to the need for upstream public health action. More work soon from this collaboration! www.sciencedirect.com/science/arti...
sciencedirect.com
Prevalence and co-occurrence of dementia risk factors in Denmark: A nationwide study
The clustering of dementia risk factors is common and has implications for policies targeting risk reduction.To estimate the prevalence of 16 dementia…
050
Seb Walsh @sebwalsh.bsky.social · 14/08/2025
We assume that the built environment affects how active we are but solid evidence lacking. Important paper from 🇺🇸 using📱data to show moving from less walkable neighbourhood to more, or vice versa, has meaningful effect on activity, sustained 3 months after moving www.nature.com/articles/s41...
nature.com
Countrywide natural experiment links built environment to physical activity - Nature
By analysing the smartphone data of 2,112,288 participants, in particular observing and comparing the activity of the same individual in two different environments, we find that increases in the walka...
030
Seb Walsh @sebwalsh.bsky.social · 28/07/2025
Interested? Take a read (it's open access) and get in touch. Big thanks to co-authors, brought together under the DEMON Network /End
020
Seb Walsh @sebwalsh.bsky.social · 28/07/2025
The hope is that this provides a platform for people starting out in the dementia research field to make it easier to incorporate an SDOD lens, by knowing what evidence we do have and where the gaps are 3/
120
Seb Walsh @sebwalsh.bsky.social · 28/07/2025
...all evidence linking social determinants to dementia across 6 domains (education, food environment, housing, SES, physical environment, and social inclusion) identifying where there are reviews/meta-analyses, where there is only primary evidence, and where we have nothing 2/
110
Seb Walsh @sebwalsh.bsky.social · 28/07/2025
What evidence do we have on the Social Determinants of Dementia (SDOD)? Delighted that this scoping review, a year or so in the making, is now published in @alzdemjournals.bsky.social. Expertly led by Anouk Geraets, we identified... doi.org/10.1002/alz.... 1/
1145
Seb Walsh @sebwalsh.bsky.social · 25/07/2025
Making social sciences foundational to academic medicine - putting the 'social' into 'social determinants of health'. dx.plos.org/10.1371/jour...
dx.plos.org
Making social sciences foundational to academic medicine
In this Perspective, Sahar Sadjadi and colleagues discuss the imperative for incorporating social sciences into medical research, education and implementation.
020
Seb Walsh @sebwalsh.bsky.social · 24/07/2025
Adherence to four dietary indices and the risk of all‐cause and cause‐specific dementia: Findings from the UK Biobank study - Carrasco‐Marín - Diabetes, Obesity and Metabolism - Wiley Online Library dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...
dom-pubs.pericles-prod.literatumonline.com
Error - Cookies Turned Off
000
Seb Walsh @sebwalsh.bsky.social · 15/07/2025
Dementia and the disappearing subject: a framing analysis of drugs for dementia in UK news media doi.org/10.1016/j.ss...
doi.org
Redirecting
020
Seb Walsh @sebwalsh.bsky.social · 11/07/2025
Analyses from Sweden suggesting that cognitive reserve is really rooted in early life, with limited opportunity therefore to affect this in adulthood. Supported by findings from the 1946 birth cohort in the UK doi.org/10.1002/alz....
doi.org
A lifespan perspective on cognitive reserve and risk for dementia
INTRODUCTION We addressed whether higher education plays a causal role in reducing dementia risk by comparing two indices of cognitive reserve: education and young adult general cognitive ability (G...
030
Seb Walsh @sebwalsh.bsky.social · 04/07/2025
Great to work on this with UK colleagues Naaheed Mukadam, Gill Livingston (@uclpsychiatry.bsky.social), and Carol Brayne (@cph.bsky.social). Susanne Roehr, and colleagues from Uni of Auckland
010
Seb Walsh @sebwalsh.bsky.social · 04/07/2025
Issue with PAFs for dementia are that we could never actually achieve risk factor eradication So, in 🇳🇿 , Etu Ma'u has led modelling of 15-25% reductions in risk factors (still ambitious) and shown meaningful PIFs over time, esp for Maori and Pacific peoples doi.org/10.1002/alz....
120
Seb Walsh @sebwalsh.bsky.social · 26/06/2025
Huge thanks to co-authors: @jackmbirch.bsky.social , Richard Merrick, Lindsay Wallace, @ilk21.bsky.social , Linda Clare, Oli Mytton, Louise Lafortune, Wendy Wills, Carol Brayne @cph.bsky.social And to funder: @nihr.bsky.social #Dementia #PublicHealth
010
Seb Walsh @sebwalsh.bsky.social · 26/06/2025
Interested in learning more about population-level approaches to dementia risk reduction? Check out our Population-Level Approaches to Dementia Risk Reduction (PLADRR) research group webpages: coghealth.net.au/population-b... including our evidence hub! 4/
coghealth.net.au
Population-Level Approaches to Dementia Risk Reduction (PLADRR) Research Group – IRNDP
110
Seb Walsh @sebwalsh.bsky.social · 26/06/2025
By comparing against our previous work on what population-level, low-agency interventions are effective at lowering dementia risk factors (see: doi.org/10.1016/j.ec...) we make 4 recommendations for new policies, and 7 recommendations for policies that could be strengthened 3/
110
Seb Walsh @sebwalsh.bsky.social · 26/06/2025
We find a general balance across reach and agency (see figure). But with reports of a trend towards individual-level and high-agency interventions (see: health.org.uk/reports-and-...). 2/
100
Seb Walsh @sebwalsh.bsky.social · 26/06/2025
Delighted to see the final paper from my PhD published in BMJ Public Health. A scoping review of dementia primary prevention policies in England: do they balance reach and agency? 1/ bmjpublichealth.bmj.com/content/3/1/...
bmjpublichealth.bmj.com
Scoping review of dementia primary prevention policies in England: do they balance reach and agency?
Objectives To ascertain the balance of dementia risk reduction policies in England, considering their reach (population-wide vs targeted at specific individuals) and agency (the level of resource requ...
181
Seb Walsh @sebwalsh.bsky.social · 14/06/2025
>10 years old but still as relevant - 10 tips for progressing from PhD to PI from @martinwhite33.bsky.social fuseopenscienceblog.blogspot.com/2012/05/from...
fuseopenscienceblog.blogspot.com
From PhD to PI in ten 'easy' steps
Our warts-and-all account of what it's like to do public health research.
042
Reposted by Seb Walsh
Marianne Piano @mporthoptics.bsky.social · 10/06/2025
Next up is Prof Ngaire Kerse with a lot of great updates on what's happening in Aotearoa for dementia care and population level risk reduction. Look @sebwalsh.bsky.social it's your equali-tree! #ANZSGM2025
Ngaire in a patterned top stands at a podium next to slides showing a Withered tree and a blooming tree
111
Seb Walsh @sebwalsh.bsky.social · 24/05/2025
A couple of months ago in @bmj.com (I’m that far behind!). This is something we should care about. We need a medical workforce that is diverse and who can relate to patients and others in the MDT.
072
Seb Walsh @sebwalsh.bsky.social · 20/05/2025
Interested in how we lower the population's risk of developing? Check out the refreshed webpages of our research group, including an up to date Evidence Hub. Interested in learning more? Get in touch! coghealth.net.au/population-b...
020
Seb Walsh @sebwalsh.bsky.social · 16/05/2025
theconversation.com/the-roots-of...
theconversation.com
The roots of dementia can start in childhood – prevention should be a lifelong goal
It’s never too early – or late – to protect your brain. Research shows dementia prevention could begin as early as childhood.
031
Seb Walsh @sebwalsh.bsky.social · 15/05/2025
theconversation.com/do-people-re...
theconversation.com
Do people really want to know their risk of getting Alzheimer’s?
A US study shows that many research participants don’t want to know their risks of getting Alzheimer’s disease.
012
Seb Walsh @sebwalsh.bsky.social · 12/05/2025
The Limited Role of Alzheimer Disease Blood-Based Biomarkers in Primary Care jamanetwork.com/journals/jam...
jamanetwork.com
The Limited Role of Alzheimer Disease Blood-Based Biomarkers in Primary Care
This Viewpoint examines the use of blood-based biomarkers to test for Alzheimer disease and outlines why they should not be the first or only tool used in screening for cognitive impairment.
010
Seb Walsh @sebwalsh.bsky.social · 09/05/2025
V important paper from Sarah and team on external validity of cognitive assessment studies. Non-response in cognitive studies is not random - people not taking part are older, have lower cognition, and reduced functioning. Must weight analyses! alz-journals.onlinelibrary.wiley.com/doi/full/10....
alz-journals.onlinelibrary.wiley.com
Factors associated with non‐participation in the Healthy Cognitive Ageing Project
BACKGROUND Understanding cognitive decline trajectories is crucial for dementia prevention, as many cases go undetected. Identifying participation biases in such studies is essential for data validi.....
020
Seb Walsh @sebwalsh.bsky.social · 03/05/2025
In population-based study (Kungsholmen), NPVs high but PPVs for blood based biomarkers 30% for single biomarkers, 45% for combination. Median follow-up 10 years. Just can't see how screening could ever be feasible with these kinds of values www.nature.com/articles/s41...
nature.com
Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community - Nature Medicine
In a community-based cohort of more than 2,000 older adults from Sweden, blood biomarkers for Alzheimer’s disease were able to predict dementia up to 16 years before disease onset.
010
Seb Walsh @sebwalsh.bsky.social · 15/04/2025
Hi Mark, thanks. Not directly. Framing all in terms of healthy yrs vs. yrs with dementia. Table 2 HRs are closest. Do you need numbers for something specific? Happy to connect you with lead authors I think APOE effect is mostly a Caucasian phenomenon - which is why diverse datasets so important!
100
Seb Walsh @sebwalsh.bsky.social · 15/04/2025
In this Chinese population-based sample, we found that health behaviours were more strongly linked to living longer without getting dementia, compared to APOE e4 genotype. Though we didn't see any compression of the dementia morbidity (once it occurred) doi.org/10.1002/alz....
131
Seb Walsh @sebwalsh.bsky.social · 03/04/2025
Shingles vaccination programme in Wales appears to be associated with reduction in dementia risk. Healthcare records aren't a perfect way of capturing dementia incidence but this is a potentially important finding rdcu.be/egagG
rdcu.be
A natural experiment on the effect of herpes zoster vaccination on dementia
Nature - Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a...
3106
Seb Walsh @sebwalsh.bsky.social · 26/03/2025
Systematic review of MCI prognosis from @simonesalemme.bsky.social population-based samples show almost half the conversion rate, and more than double the rate of reversion to normal cognition, compared to clinical samples. alz-journals.onlinelibrary.wiley.com/doi/full/10....
alz-journals.onlinelibrary.wiley.com
The prognosis of mild cognitive impairment: A systematic review and meta‐analysis
INTRODUCTION Knowledge gaps remain about the prognosis of mild cognitive impairment (MCI). Conversion rates to dementia vary widely, and reversion to normal cognition has gained attention. This revi...
010
Seb Walsh @sebwalsh.bsky.social · 24/03/2025
In this relatively affluent sample, social support seemed to mitigate SDOH relationship with dementia for men but not women Social determinants of health and risk of dementia among older men and women: A 12‐year cohort study in Australia alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
010
Seb Walsh @sebwalsh.bsky.social · 21/03/2025
Excellent summary of our recent study from Naaheed Mukadam @ucl.ac.uk and @nihr.bsky.social Population-level policies on risk factors for dementia could reduce costs evidence.nihr.ac.uk/alert/popula...
evidence.nihr.ac.uk
Population-level policies on risk factors for dementia could reduce costs
Population-level policies that target risk factors for dementia save money and give people extra years in good health, a modelling study found.
033
Seb Walsh @sebwalsh.bsky.social · 21/03/2025
Thanks a lot Alice! Full paper open access here: pubmed.ncbi.nlm.nih.gov/39023302/ We also have a grant in to check these analyses in various global cohorts, including LMICs. Would be good to see for other late-life diseases too!
pubmed.ncbi.nlm.nih.gov
How many future dementia cases would be missed by a high-risk screening program? A retrospective cohort study in a population-based cohort - PubMed
Dementia, a significant public health challenge, is not an inevitability of aging; risk reduction is possible. Several dementia risk prediction models have been validated in the general population, an...
011
Seb Walsh @sebwalsh.bsky.social · 20/03/2025
it wasn't statistically significant. It was null.
010
Seb Walsh @sebwalsh.bsky.social · 17/03/2025
Dear Outlook: my mailbox would be a lot less full if you stopped emailing me to tell me how full it was 🙃
010
Seb Walsh @sebwalsh.bsky.social · 17/03/2025
Changing story of the dementia epidemic jamanetwork.com/journals/jam...
jamanetwork.com
Changing Story of the Dementia Epidemic
This Viewpoint discusses age-specific dementia prevalence rates, their decline during 40 years, and the subsequent effect on dementia incidence.
051
Seb Walsh @sebwalsh.bsky.social · 14/03/2025
Reality check on AD biomarkers from @cdufouil.bsky.social at DPUK conference In MEMENTO, minimal variability of BBMs explained by clinical factors. And BBMs add little predictive ability beyond standard demographic/neuropsych tests What happens when outcome = people instead of PET scans!
011
Seb Walsh @sebwalsh.bsky.social · 12/03/2025
Join us online or in-person for this @alzresearchuk.bsky.social East open meeting for the #CambridgeFestival next Friday at the University Centre (or online). I'll be talking on population-level approaches to dementia risk reduction www.eventbrite.co.uk/e/alzheimers...
eventbrite.co.uk
Alzheimer's Research UK East Network Public Meeting 2025 - ONLINE
Find out more about taking a population based approach to reduce risk of dementia and music therapy for dementia patients
020
Seb Walsh @sebwalsh.bsky.social · 07/03/2025
Living in poverty in childhood increases the likelihood of poverty in adulthood But it's not inevitable, and some countries (Denmark, Germany, Oz, UK) are much better than others (USA) at reducing this 'intergenerational transmission of poverty' www.nature.com/articles/s41...
nature.com
Intergenerational persistence of poverty in five high-income countries - Nature Human Behaviour
Children born in poverty are more likely to experience poverty as adults, but this likelihood is greater in the United States than in Australia, Denmark, Germany or the United Kingdom. The authors exa...
020
Seb Walsh @sebwalsh.bsky.social · 18/02/2025
Are you interested in policy action to reduce population dementia risk? A reminder to join us online for these three, free expert talks and Q&A starting at: NZ = 27th Feb 9am UK = 26th Feb 8pm EST = 26th Feb 3pm www.eventbrite.com/e/public-lec...
eventbrite.com
Public Lecture | Dementia Risk Reduction for All
Discover population-level approaches to dementia risk reduction (PLADRR): what they are, how they work, and why they matter.
020