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Leon Schulte

@schultelab.bsky.social
70 followers 107 following 5 posts

Human immunology through the RNA lens. Focused on macrophages, lncRNAs & systems immunology. Professor for RNA- and infection-biology @unimarburg.bsky.social. Web: rna-lab.org

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Reposted by Leon Schulte
Helmholtz-Zentrum für Infektionsforschung (HZI) @helmholtzhzi.bsky.social · 20/07/2026
Die Studie, die in @pnas.org erschienen ist, ist das Ergebnis einer Kooperation von @westermannlab.bsky.social & @jorg-vogel-lab.bsky.social mit @schultelab.bsky.social @unimarburg.bsky.social und vielen weiteren Partnern. www.pnas.org/doi/10.1073/...
pnas.org
A human-specific long noncoding RNA regulator of antigen-presenting cell viability and antimicrobial defense | PNAS
Macrophages are essential for both, to clear pathogens and preserve tissue homeostasis, yet the molecular regulators of this equilibrium remain inc...
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Leon Schulte @schultelab.bsky.social · 17/07/2026
Excited to share our PNAS paper with @jorg-vogel-lab.bsky.social and @westermannlab.bsky.social! We identify SAILR, a human-specific lncRNA that binds 14-3-3β to support macrophage viability—its loss during infection strengthens antimicrobial defense. #RNA www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Leon Schulte
evgenia ntini @evgeniantini.bsky.social · 21/11/2025
Tuesday 25.11 13:00 CET we are happy to host Prof. Leon Schulte (rna-lab.org) @schultelab.bsky.social join us for an exciting talk "Multi-omic Dissection of Regulatory lncRNA-Protein Networks in Innate Immunity" thanks @rnasociety.bsky.social @imbb-forth.bsky.social us02web.zoom.us/meeting/regi...
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Reposted by Leon Schulte
versteegga.bsky.social @versteegga.bsky.social · 01/07/2025
Our latest study is now out in @narjournal.bsky.social‬: we identify a post-transcriptional bottleneck in interferon gamma signaling that hinges on proper maturation of JAK2 mRNA. Paper: academic.oup.com/nar/article/...
academic.oup.com
ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA
Abstract. Type II interferon (IFNγ) signaling is essential for innate immunity and critical for effective immunological checkpoint blockade in cancer immun
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Leon Schulte @schultelab.bsky.social · 22/05/2025
How do long noncoding RNAs help macrophages fight bacteria? We built a whole atlas to explore this question — and it’s now published in Nature Communications! 🔗 rdcu.be/em7aM #lncRNA #macrophage #immunology
rdcu.be
A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages
Nature Communications - Long non-coding RNAs (lncRNA) are known immune regulators, yet a systemic understanding of their regulatory crosstalk is still elusive. Here the authors establish a platform...
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Leon Schulte @schultelab.bsky.social · 22/05/2025
We also built SMyLR, a searchable online resource for the immune-lncRNA community: Explore pathway dependencies, subcellular localization, and protein interactors of hundreds of lncRNAs in macrophages: 🔍 rna-lab.org/smylr/ More info in our paper: 🔗 rdcu.be/em7aM #lncRNA #openscience #macrophage
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Leon Schulte @schultelab.bsky.social · 22/05/2025
Meet GRADR: our new approach to chart lncRNA–protein interactions transcriptome-wide. By combining gradient profiling and RNA-binding proteomics, GRADR reveals which lncRNAs engage which protein machineries. 📘 Step-by-step protocol included in: 🔗 www.nature.com/articles/s41... #lncRNA #methods
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Leon Schulte @schultelab.bsky.social · 21/05/2025
We’re now on Bluesky! This space will share updates from our lab, covering RNA biology, macrophage immunology, and long noncoding RNAs. Follow along for papers, resources & insights from the bench. #lncRNA #macrophage #immunology #RNA #biomed #openscience
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