Motivation: BWA-MEM remains a popular short-read mapper especially for the purpose of variant calling. Several groups have accelerated this algorithm as it has been the performance bottleneck of many ...

npj Digital Medicine - Rethinking bioinformatics expertise in the era of artificial intelligence

Abstract. The Arabidopsis Information Resource (TAIR) is the primary knowledgebase for Arabidopsis thaliana, providing curated genetics and genomics data,

India, the most populous country, remains significantly underrepresented in the global genomics landscape. Previous efforts to catalog Indian genetic diversity were limited in scale, scope, and repres...

Probabilistic models such as the sequentially Markovian coalescent have long provided a powerful framework for population genetic inference, enabli...

The second International AI Safety Report, published in February 2026, is the next iteration of the comprehensive review of latest scientific research on the capabilities and risks of general-purpose ...

Anthropic is an AI safety and research company that's working to build reliable, interpretable, and steerable AI systems.

Venter redrew the boundaries of biology — sequencing DNA at unprecedented speed, engineering synthetic life and charting ocean microbes.

scPlantReg is a framework and database for plant single-cell chromatin data, with scATACtor for cell-type identification. Applied to pearl millet, it identifies WRKYs involved in xylem development and...

To ensure the security and long-term stability of our data delivery infrastructure, NCBI will discontinue support for the rsync protocol on June 1, 2026. After June 1, attempts to connect to ftp.ncbi....

GitNexus: The Zero-Server Code Intelligence Engine - GitNexus is a client-side knowledge graph creator that runs entirely in your browser. Drop in a GitHub repo or ZIP file, and get an intera...

QuadPE—a quadruple paired prime editing guide RNA strategy—enables efficient and programmable insertion of large DNA fragments.

sc-SPLASH extends reference-free analysis to barcoded single-cell and spatial transcriptomics data.

This Review describes how an approach that starts from genetic changes under selection during human evolution and integrates comparative and functional studies can reveal adaptive phenotypes across di...

Many plants, unlike most animals, can reproduce as clones [D. Kester, HortScience 18, 831–837 (1983), 10.21273/hortsci.18.6.831]. Cloning plants is...

ThermoCas9, a genome-editing enzyme that is sensitive to the DNA methylation status of the target locus, is characterized and shows promise for targeting hypomethylated DNA regions in cancer cells.

OpenProtein develops state-of-the-art protein language models and a protein design cloud platform that enables users to design, evaluate, and optimize proteins with high precision and efficiency. Expl...

Today, we’re launching Claude Design, a new Anthropic Labs product that lets you collaborate with Claude to create polished visual work like designs, prototypes, slides, one-pagers, and more.

BRAKER re-implemented with snakemake. Contribute to Gaius-Augustus/BRAKER4 development by creating an account on GitHub.

Anthropic is an AI safety and research company that's working to build reliable, interpretable, and steerable AI systems.

Put Claude Code on autopilot. Define routines that run on a schedule, trigger on API calls, or react to GitHub events from Anthropic-managed cloud infrastructure.

We're launching multiple updates to Windsurf today: an Adaptive model router, a redesigned model picker with pricing context, and the removal of daily limits for Max.

CREsted is an efficient and user-friendly toolbox for analysis, modeling and design of cell-type-specific enhancers across diverse species.

In this study, long-read RNA sequencing achieves accurate single-nucleotide polymorphism calling, haplotype phasing and allele-specific expression analysis.

Ancient DNA shows that hunter-gatherers in northwestern Europe endured for millennia, with women driving a gradual cultural shift toward farming.

This study shows that many small RNAs in Capsella rubella pollen originate from maternal tissues. These mobile small RNAs support proper pollen development, revealing that non-cell-autonomous small RN...

To decipher the regulatory basis of nitrogen, use efficiency (NUE), we built maize- and sorghum-specific gene regulatory networks (GRNs). Cross-species analyses revealed conserved and species-specifi...

A hand stencil painted on a cave wall on a small island off the coast of Sulawesi more than 67,800 years ago suggests a very early occupation of Wallacea.

As the global population continues to rise, the demand for agricultural productivity intensifies. However, the challenge is not just about increasing yields; it is about doing so sustainably under con...

By Arjun Raj, members of the lab, and various others

Diatoms exert reciprocal, fine-scale control of P acquisition by N availability, depending on the immediate needs of the cell.

Accumulation of proanthocyanidin (PA) in the seed coat determines black to brown seed color in Brassicaceae members. Consequently, yellow-seed coat re…

C4 photosynthesis enhances carbon fixation efficiency by reducing photorespiration through the use of an oxygen-insensitive carboxylase and spatial separation of photosynthesis between mesophyll and ....

Alternative polyadenylation is involved in plant responses to various stresses. Here, the authors show how a cis-natural antisense RNA promotes proximal polyadenylation of its cognate SlSPX5 gene in r...

The combinatorial changes in DNA methylation, post-translational histone modifications, and histone variants underlie the complexity of chromatin stru…

A genomic study of 2,762 individuals from India offers important insights into the genomic diversity and evolutionary history of the subcontinent and highlights the extensive genetic variation, gene f...

Plants suppress the DNA demethylase ROS1 under heat stress to limit transposon activation, preventing genome instability. This conserved mechanism balances stress adaptation with genome protection.

This protocol uses the R microeco package to provide a pipeline for the statistical analysis and visualization of microbiome data, covering omics data types such as amplicon sequencing data, metagenom...

Here, the authors discuss principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches, highlighting common expe...

A noncanonical pathway of DELLA regulation by a conserved inositol pyrophosphate synthase was identified in the liverwort, Marchantia polymorpha, that lacks the canonical gibberellin-induced DELLA deg...

Genomic and functional analyses reveal that the potato lineage originated from a homoploid interspecific hybridization event between the Tomato and Etuberosum lineages 8–9 million years ago. The alter...

Inorganic phosphate (Pi) is essential for life, and plant cells monitor Pi availability by sensing inositol pyrophosphate (PP-InsP) levels. In this work, we describe the hijacking of plant phosphate s...

Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.

Latest updates and changes for the Windsurf Editor.

This Review discusses the various molecular mechanisms underlying the generation of new genes and highlights their important functions and phenotypes with an emphasis on the evolutionary forces underl...

Comparing Windsurf & Cursor AI-powered IDEs: features, user experience & workflow efficiency. Which is best for you?

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

This study characterizes the plant inorganic phosphate transporter PHO1 through cryogenic electron microscopy and biochemical and physiological analysis, revealing the molecular and regulatory mechani...