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Santosh

@santosh-s.bsky.social

Biochemist trying to solve the mysteries of cellular proteostsis by weighing peptides in @thecrick.bsky.social with @davidbalchin.bsky.social

Posts Replies Media

Reposted by Santosh

The Francis Crick Institute @crick.ac.uk · 16/06/2026

Join @davidbalchin.bsky.social, group leader here at the Crick, as he describes the fascinating ways our cells ensure that proteins fold correctly, and what happens when this goes awry in disease. youtu.be/gEgK1JDNlZ8

youtu.be

How Are We So Good at Folding Proteins? - With David Balchin

YouTube video by The Francis Crick Institute

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Reposted by Santosh

David Balchin @davidbalchin.bsky.social · 22/04/2026

New from our lab @crick.ac.uk. Nascent proteins emerge from the human ribosome into a cytosol packed with hundreds of different molecular chaperones. Which chaperones recognise specific nascent chains, and what dictates their binding preferences? www.biorxiv.org/content/10.6...

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Reposted by Santosh

David Balchin @davidbalchin.bsky.social · 12/01/2026

If anyone is interested in making bacterial ribosome-nascent chain complexes and studying them using HDX-MS, we have written up a detailed protocol. rdcu.be/eYFx4 Characterise the conformational dynamics of the ribosome, nascent polypeptide and bound chaperones, label-free and at peptide-level

rdcu.be

Client Challenge

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Reposted by Santosh

Andy Truman PhD @trumanlab.bsky.social · 03/01/2026

We are looking for talented graduate students to join our group for Fall 2026 studying the role and regulation of Hsp70 PTMs! If you are interested please check out www.trumanlab.org

trumanlab.org

Cancer Research Laboratory | Trumanlab | UNC Charlotte | United States

The Trumanlab at UNC Charlotte incorporates protein biochemistry, molecular biology, proteomics, systems biology, bacterial and yeast genetics as well as cell culture technologies to identify novel an...

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Reposted by Santosh

David Balchin @davidbalchin.bsky.social · 02/06/2025

New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs. By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis. www.biorxiv.org/content/10.1...

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Santosh @santosh-s.bsky.social · 31/03/2025

Wishing you good luck on your endeavours.

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Reposted by Santosh

David Balchin @davidbalchin.bsky.social · 21/02/2025

Just one week left to apply!

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Santosh @santosh-s.bsky.social · 05/02/2025

Wishing you strength and success !!!

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Santosh @santosh-s.bsky.social · 03/02/2025

For mammalian cells, is it enough to use phosphatase inhibitors during lysis, or should I wash the cells with PBS containing phosphatase inhibitors before freezing the cells in liquid N2 for storage? TIA!! #TeamMassSpec #Protoemics

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Santosh @santosh-s.bsky.social · 29/01/2025

Rachel Mehaffey from the Biognosys support team has been extremely helpful. Most of my Spectronaut learning has been from her, and your youtube videos. Thank you!!

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Santosh @santosh-s.bsky.social · 14/11/2024

I could not find the membrane after a Western transfer!!!

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