iiinova — where your digital self keeps evolving

Samuel Tingle @samjtingle.bsky.social · 26/11/2025

🙏 Huge thank you to @georgek.medsky.social (co-developer of the package), Sarah Elliot , and @ewenharrison.bsky.social for their guidance and support.

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Samuel Tingle @samjtingle.bsky.social · 26/11/2025

🔗 Additional resources provided: - Regression modelling playground web application: geokour.shinyapps.io/Non_linear_m... - R scripts with case study workflow as supplementary materials and on GitHub: github.com/rmsMD/Non-li... - Further vignettes on the rmsMD website: rmsmd.github.io/rmsMD

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Samuel Tingle @samjtingle.bsky.social · 26/11/2025

❓ Why this matters: - Default regression models assume that relationships form straight lines - Linearity assumption is often inappropriate in healthcare data - We discuss pitfalls, and provide with educational tools - We work through a simple case study and provide all code

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Samuel Tingle @samjtingle.bsky.social · 26/11/2025

🔥 Launch of rmsMD R package 🔥 📈 Streamlined functions for summarising and visualising non-linear regression models 🔑 Core focus is simplicity, and output of publication ready tables and plots for medical journals 🔗http://rmsmd.github.io/rmsMD

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Samuel Tingle @samjtingle.bsky.social · 26/11/2025

🚨📢 Incredibly proud to share our new paper and R package on non-linear regression modelling for medical professionals; making it simple! 🔗 Open access paper: doi.org/10.1093/post... #rstats #nonlinear #biostatistics More details 🧵👇👇👇

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Reposted by Samuel Tingle

American Journal of Kidney Diseases @ajkd.bsky.social · 23/05/2025

Machine Perfusion in Deceased Donor Kidney Transplantation: Editorial Summary of a Cochrane Review by @samjtingle.bsky.social and Colin Hugh Wilson bit.ly/AJKD25Tingle... (FREE)

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Samuel Tingle @samjtingle.bsky.social · 02/04/2025

💡 Why it matters: CEUS could provide real-time, objective assessment during NMP—supporting viability decisions at organ assessment and reconditioning centres (ARCs) ❗️But validation in transplanted kidneys is still needed

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Samuel Tingle @samjtingle.bsky.social · 02/04/2025

🔑 Key findings from porcine and human kidney models: 1️⃣ Microvascular perfusion at 2h correlated with markers of injury 2️⃣ Total renal blood flow did not 3️⃣ CEUS is safe, non-toxic, & potentially bedside-friendly

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Samuel Tingle @samjtingle.bsky.social · 02/04/2025

❓Can we predict kidney viability before transplantation—non-invasively, in real time? Our latest study explores contrast-enhanced ultrasound (CEUS) during normothermic machine perfusion (NMP) to assess microvascular perfusion, a key factor in ischaemia-reperfusion injury🧵👇

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Reposted by Samuel Tingle

Maarten van Smeden @maartenvsmeden.bsky.social · 02/12/2024

Introducing the new "NOPE" algorithm This algorithm will tell you "no" all the time. It has been shown to be up to 95% accurate in situations with a prevalence of 5% and *what is even better* even *more accurate* in rarer diseases

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Reposted by Samuel Tingle

Hannes Jansson @hannesjsson.bsky.social · 12/11/2024

Started an HPB surgery starter pack! go.bsky.app/7Z2kqK6 Let’s add to the list! Residents, fellows, attendings, professors 😊

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Samuel Tingle @samjtingle.bsky.social · 19/11/2024

🔑 Time to death was not associated with recipient eGFR, DGF or graft survival 🔑 Compared to a 1 hour stand down policy, the 3 hour minimum wait ⬆️ #DCD transplant by 14% 🔑 Simple and safe change for organ donation organisations globally

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Samuel Tingle @samjtingle.bsky.social · 19/11/2024

Amazing to see this published in JAMA network open after so much work from a great team 🎉 ❓ Does #DCD donor time to death impact kidney transplant outcomes? 🔑 We assessed this in a UK cohort, where the minimum stand-down time is 3 hours! ⬇️ Full #OpenAccess paper

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